Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population

Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed...

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Bibliographic Details
Authors: Loeb, Eduardo, Zock, Jan-Paul|||0000-0002-2941-6259, Miravitlles, Marc|||0000-0002-9850-9520, Rodríguez, Esther|||0000-0001-8572-5198, Kromhout, Hans|||0000-0002-4233-1890, Vermeulen, Roel|||0000-0003-4082-8163, Soler-Cataluña, Juan José|||0000-0003-1134-0783, Soriano, Joan B.|||0000-0001-9740-2994, García-Rio, Francisco|||0000-0002-7227-2238, de Lucas-Ramos, Pilar|||0000-0002-9377-8262, Alfageme, Inmaculada|||0000-0002-5106-1669, Casanova, Ciro|||0000-0001-7364-7508, Rodríguez González-Moro, José Miguel|||0000-0002-8446-3373, Ancochea, Julio|||0000-0001-7451-4133, Cosio, Borja G.|||0000-0002-6388-8209, Ferrer Sancho, Jaume|||0000-0001-6616-0670
Format: article
Publication Date:2024
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:302607
Online Access:https://ddd.uab.cat/record/302607
https://dx.doi.org/urn:doi:10.3390/toxics12100689
Access Level:Open access
Keyword:Chronic obstructive pulmonary disease
COPD
Occupational exposures
Job exposure matrix
JEM
Computed tomography
Emphysema
Description
Summary:Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19-4.22), biological dust (OR 3.01 95% CI 1.22-7.45), gases/fumes (OR 2.49 95% CI 1.20-5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21-16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42-24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16-15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population.

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