Benznidazole Treatment

Fonseca, Kátia da Silva; Perin, Luísa; de Paiva, Nívia Carolina Nogueira; da Silva, Beatriz Cristiane; Duarte, Thays Helena Chaves; Marques, Flávia de Souza; Costa, Guilherme de Paula; Molina Romero, Israel|||0000-0001-6642-7515; Correa-Oliveira, Rodrigo|||0000-0001-6419-9459; Vieira, Paula Melo de Abreu|||0000-0001-7033-7686; Carneiro, Cláudia Martins|||0000-0002-6002-857X

Benznidazole Treatment

As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different the...

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Detalhes bibliográficos
Autores:	Fonseca, Kátia da Silva, Perin, Luísa, de Paiva, Nívia Carolina Nogueira, da Silva, Beatriz Cristiane, Duarte, Thays Helena Chaves, Marques, Flávia de Souza, Costa, Guilherme de Paula, Molina Romero, Israel\|\|\|0000-0001-6642-7515, Correa-Oliveira, Rodrigo\|\|\|0000-0001-6419-9459, Vieira, Paula Melo de Abreu\|\|\|0000-0001-7033-7686, Carneiro, Cláudia Martins\|\|\|0000-0002-6002-857X
Formato:	artículo
Fecha de publicación:	2021
País:	España
Recursos:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:256459
Acesso em linha:	https://ddd.uab.cat/record/256459 https://dx.doi.org/urn:doi:10.3390/pathogens10060729
Access Level:	acceso abierto
Palavra-chave:	Chagas disease Trypanosoma cruzi Benznidazole Therapeutic strategies Mice

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spelling	Benznidazole TreatmentTime- and Dose-Dependence Varies with the Trypanosoma cruzi StrainFonseca, Kátia da SilvaPerin, Luísade Paiva, Nívia Carolina Nogueirada Silva, Beatriz CristianeDuarte, Thays Helena ChavesMarques, Flávia de SouzaCosta, Guilherme de PaulaMolina Romero, Israel\|\|\|0000-0001-6642-7515Correa-Oliveira, Rodrigo\|\|\|0000-0001-6419-9459Vieira, Paula Melo de Abreu\|\|\|0000-0001-7033-7686Carneiro, Cláudia Martins\|\|\|0000-0002-6002-857XChagas diseaseTrypanosoma cruziBenznidazoleTherapeutic strategiesMiceAs the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different therapeutic schemes with benznidazole (BNZ) on the acute and chronic phases of the disease, using mice infected with strains that have different BNZ susceptibilities. Our results show that the groups of animals infected by VL-10 strain, when treated in the chronic phase with a lower dose of BNZ for a longer period of time (40 mg/kg/day for 40 days) presented better treatment efficacy than with the standard protocol (100 mg/kg/day for 20 days) although the best result in the treatment of the animals infected by the VL-10 strain was with100 mg/kg/day for 40 days. In the acute infection by the Y and VL-10 strains of T. cruzi, the treatment with a standard dose, but with a longer time of treatment (100 mg/kg/day for 40 days) presented the best results. Given these data, our results indicate that for BNZ, the theory of dose and time proportionality does not apply to the phases of infectionUniversitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/256459https://dx.doi.org/urn:doi:10.3390/pathogens10060729reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2564592026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Benznidazole Treatment Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain
title	Benznidazole Treatment
spellingShingle	Benznidazole Treatment Fonseca, Kátia da Silva Chagas disease Trypanosoma cruzi Benznidazole Therapeutic strategies Mice
title_short	Benznidazole Treatment
title_full	Benznidazole Treatment
title_fullStr	Benznidazole Treatment
title_full_unstemmed	Benznidazole Treatment
title_sort	Benznidazole Treatment
dc.creator.none.fl_str_mv	Fonseca, Kátia da Silva Perin, Luísa de Paiva, Nívia Carolina Nogueira da Silva, Beatriz Cristiane Duarte, Thays Helena Chaves Marques, Flávia de Souza Costa, Guilherme de Paula Molina Romero, Israel\|\|\|0000-0001-6642-7515 Correa-Oliveira, Rodrigo\|\|\|0000-0001-6419-9459 Vieira, Paula Melo de Abreu\|\|\|0000-0001-7033-7686 Carneiro, Cláudia Martins\|\|\|0000-0002-6002-857X
author	Fonseca, Kátia da Silva
author_facet	Fonseca, Kátia da Silva Perin, Luísa de Paiva, Nívia Carolina Nogueira da Silva, Beatriz Cristiane Duarte, Thays Helena Chaves Marques, Flávia de Souza Costa, Guilherme de Paula Molina Romero, Israel\|\|\|0000-0001-6642-7515 Correa-Oliveira, Rodrigo\|\|\|0000-0001-6419-9459 Vieira, Paula Melo de Abreu\|\|\|0000-0001-7033-7686 Carneiro, Cláudia Martins\|\|\|0000-0002-6002-857X
author_role	author
author2	Perin, Luísa de Paiva, Nívia Carolina Nogueira da Silva, Beatriz Cristiane Duarte, Thays Helena Chaves Marques, Flávia de Souza Costa, Guilherme de Paula Molina Romero, Israel\|\|\|0000-0001-6642-7515 Correa-Oliveira, Rodrigo\|\|\|0000-0001-6419-9459 Vieira, Paula Melo de Abreu\|\|\|0000-0001-7033-7686 Carneiro, Cláudia Martins\|\|\|0000-0002-6002-857X
author2_role	author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Chagas disease Trypanosoma cruzi Benznidazole Therapeutic strategies Mice
topic	Chagas disease Trypanosoma cruzi Benznidazole Therapeutic strategies Mice
description	As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different therapeutic schemes with benznidazole (BNZ) on the acute and chronic phases of the disease, using mice infected with strains that have different BNZ susceptibilities. Our results show that the groups of animals infected by VL-10 strain, when treated in the chronic phase with a lower dose of BNZ for a longer period of time (40 mg/kg/day for 40 days) presented better treatment efficacy than with the standard protocol (100 mg/kg/day for 20 days) although the best result in the treatment of the animals infected by the VL-10 strain was with100 mg/kg/day for 40 days. In the acute infection by the Y and VL-10 strains of T. cruzi, the treatment with a standard dose, but with a longer time of treatment (100 mg/kg/day for 40 days) presented the best results. Given these data, our results indicate that for BNZ, the theory of dose and time proportionality does not apply to the phases of infection
publishDate	2021
dc.date.none.fl_str_mv	2 2021-01-01 2021 2021-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/256459 https://dx.doi.org/urn:doi:10.3390/pathogens10060729
url	https://ddd.uab.cat/record/256459 https://dx.doi.org/urn:doi:10.3390/pathogens10060729
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.300724

Benznidazole Treatment

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