Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.

Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we d...

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Author: Clària i Enrich, Joan
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/184823
Online Access:https://hdl.handle.net/2445/184823
Access Level:Open access
Keyword:Cirrosi hepàtica
Resposta immunitària
Immunosupressió
Lípids
Immunopatologia
Hepatic cirrhosis
Immune response
Immunosuppression
Lipids
Immunopathology
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spelling Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.Clària i Enrich, JoanCirrosi hepàticaResposta immunitàriaImmunosupressióLípidsImmunopatologiaHepatic cirrhosisImmune responseImmunosuppressionLipidsImmunopathologyAcute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing ACLF, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [PAMPs and DAMPs]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system. This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure.De Gruyter2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/184823Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1515/almed-2021-0023Advances in Laboratory Medicine/Avances en Medicina de Laboratorio, 2021, vol. 2, num. 4, p. 516-527https://doi.org/10.1515/almed-2021-0023cc-by-nc-nd (c) Clària i Enrich, Joan, 2021https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1848232026-05-27T06:46:51Z
dc.title.none.fl_str_mv Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
title Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
spellingShingle Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
Clària i Enrich, Joan
Cirrosi hepàtica
Resposta immunitària
Immunosupressió
Lípids
Immunopatologia
Hepatic cirrhosis
Immune response
Immunosuppression
Lipids
Immunopathology
title_short Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
title_full Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
title_fullStr Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
title_full_unstemmed Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
title_sort Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.
dc.creator.none.fl_str_mv Clària i Enrich, Joan
author Clària i Enrich, Joan
author_facet Clària i Enrich, Joan
author_role author
dc.subject.none.fl_str_mv Cirrosi hepàtica
Resposta immunitària
Immunosupressió
Lípids
Immunopatologia
Hepatic cirrhosis
Immune response
Immunosuppression
Lipids
Immunopathology
topic Cirrosi hepàtica
Resposta immunitària
Immunosupressió
Lípids
Immunopatologia
Hepatic cirrhosis
Immune response
Immunosuppression
Lipids
Immunopathology
description Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing ACLF, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [PAMPs and DAMPs]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system. This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/184823
url https://hdl.handle.net/2445/184823
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1515/almed-2021-0023
Advances in Laboratory Medicine/Avances en Medicina de Laboratorio, 2021, vol. 2, num. 4, p. 516-527
https://doi.org/10.1515/almed-2021-0023
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Clària i Enrich, Joan, 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Clària i Enrich, Joan, 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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