Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis

Circulating white blood cells (leucocytes), which form the peripheral immune system, are crucial in inflammatory processes but their role in brain structural change in schizophrenia has been scarcely studied. With this study we want to determine how and which type of white blood cells are associated...

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Autores: Toll Privat, Alba, Blanco Hinojo, Laura, Bergé, Daniel, Martín-Subero, Marta, Casanovas, Francesc, El Abidi El Ghazouani, Khadija, Pérez Solà, Victor, Mané, Anna
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/225712
Acceso en línea:https://hdl.handle.net/2445/225712
Access Level:acceso abierto
Palabra clave:Depressió psíquica
Hipocamp (Cervell)
Psicosi
Mental depression
Hippocampus (Brain)
Psychoses
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spelling Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosisToll Privat, AlbaBlanco Hinojo, LauraBergé, DanielMartín-Subero, MartaCasanovas, FrancescEl Abidi El Ghazouani, KhadijaPérez Solà, VictorMané, AnnaDepressió psíquicaHipocamp (Cervell)PsicosiMental depressionHippocampus (Brain)PsychosesCirculating white blood cells (leucocytes), which form the peripheral immune system, are crucial in inflammatory processes but their role in brain structural change in schizophrenia has been scarcely studied. With this study we want to determine how and which type of white blood cells are associated with hippocampal volume (as a key structure in schi- zophrenia etiopathology) in first episode psychosis (FEP) patients. Moreover, to determine the association between white blood cells and clinical symptomatology, including positive and negative symptoms, cognition and depression. For this purpose fifty drug-naïve FEP were included in this study. All patients underwent an assessment at baseline and at 1 year follow-up, including sociodemographic and clinical variables (substance use, DUP, PANSS, GAF and CDSS). Fasting blood samples were obtained before administering any medication at baseline. Structural T1 MRI was performed at baseline and brain volumes were quantified. In the present study, higher lymphocyte count was associated with larger right hippocampal volume at baseline in FEP drug-naive patients. Higher lymphocyte count was associated with lower depressive symptomatology measured with CDSS and Marder depressive factor from PANSS at baseline and 1-year follow -up. These results suggest that lymphocytes may have a protective effect in hippocampal volume at baseli- ne in antipsychotic naïve FEP and also, are associated with a better depressive course over follow up. These results open the door to identify new biomarkers and therapeutic targets for patients with schizophrenia.Elsevier B.V.2026202620232026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/225712Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.euroneuro.2023.01.002European Neuropsychopharmacology, 2023, vol. 69, p. 47-55https://doi.org/10.1016/j.euroneuro.2023.01.002cc-by-nc-nd (c) Toll Privat, Alba et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2257122026-05-29T05:05:01Z
dc.title.none.fl_str_mv Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis
title Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis
spellingShingle Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis
Toll Privat, Alba
Depressió psíquica
Hipocamp (Cervell)
Psicosi
Mental depression
Hippocampus (Brain)
Psychoses
title_short Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis
title_full Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis
title_fullStr Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis
title_full_unstemmed Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis
title_sort Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis
dc.creator.none.fl_str_mv Toll Privat, Alba
Blanco Hinojo, Laura
Bergé, Daniel
Martín-Subero, Marta
Casanovas, Francesc
El Abidi El Ghazouani, Khadija
Pérez Solà, Victor
Mané, Anna
author Toll Privat, Alba
author_facet Toll Privat, Alba
Blanco Hinojo, Laura
Bergé, Daniel
Martín-Subero, Marta
Casanovas, Francesc
El Abidi El Ghazouani, Khadija
Pérez Solà, Victor
Mané, Anna
author_role author
author2 Blanco Hinojo, Laura
Bergé, Daniel
Martín-Subero, Marta
Casanovas, Francesc
El Abidi El Ghazouani, Khadija
Pérez Solà, Victor
Mané, Anna
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Depressió psíquica
Hipocamp (Cervell)
Psicosi
Mental depression
Hippocampus (Brain)
Psychoses
topic Depressió psíquica
Hipocamp (Cervell)
Psicosi
Mental depression
Hippocampus (Brain)
Psychoses
description Circulating white blood cells (leucocytes), which form the peripheral immune system, are crucial in inflammatory processes but their role in brain structural change in schizophrenia has been scarcely studied. With this study we want to determine how and which type of white blood cells are associated with hippocampal volume (as a key structure in schi- zophrenia etiopathology) in first episode psychosis (FEP) patients. Moreover, to determine the association between white blood cells and clinical symptomatology, including positive and negative symptoms, cognition and depression. For this purpose fifty drug-naïve FEP were included in this study. All patients underwent an assessment at baseline and at 1 year follow-up, including sociodemographic and clinical variables (substance use, DUP, PANSS, GAF and CDSS). Fasting blood samples were obtained before administering any medication at baseline. Structural T1 MRI was performed at baseline and brain volumes were quantified. In the present study, higher lymphocyte count was associated with larger right hippocampal volume at baseline in FEP drug-naive patients. Higher lymphocyte count was associated with lower depressive symptomatology measured with CDSS and Marder depressive factor from PANSS at baseline and 1-year follow -up. These results suggest that lymphocytes may have a protective effect in hippocampal volume at baseli- ne in antipsychotic naïve FEP and also, are associated with a better depressive course over follow up. These results open the door to identify new biomarkers and therapeutic targets for patients with schizophrenia.
publishDate 2023
dc.date.none.fl_str_mv 2023
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/225712
url https://hdl.handle.net/2445/225712
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.euroneuro.2023.01.002
European Neuropsychopharmacology, 2023, vol. 69, p. 47-55
https://doi.org/10.1016/j.euroneuro.2023.01.002
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Toll Privat, Alba et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Toll Privat, Alba et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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