Heteromeric amino acid transporters in brain: from physiology to pathology

In humans, more than 50 transporters are responsible for the traffic and balance of amino acids within and between cells and tissues, and half of them have been associated with disease [1]. Covering all common amino acids, Heteromeric Amino acid Transporters (HATs) are one class of such transporters...

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Detalles Bibliográficos
Autores: Errasti-Murugarren, Ekaitz, Palacín Prieto, Manuel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/218666
Acceso en línea:https://hdl.handle.net/2445/218666
Access Level:acceso abierto
Palabra clave:Transport biològic
Aminoàcids
Barrera hematoencefàlica
Biological transport
Amino acids
Blood-brain barrier
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spelling Heteromeric amino acid transporters in brain: from physiology to pathologyErrasti-Murugarren, EkaitzPalacín Prieto, ManuelTransport biològicAminoàcidsBarrera hematoencefàlicaBiological transportAmino acidsBlood-brain barrierIn humans, more than 50 transporters are responsible for the traffic and balance of amino acids within and between cells and tissues, and half of them have been associated with disease [1]. Covering all common amino acids, Heteromeric Amino acid Transporters (HATs) are one class of such transporters. This review first highlights structural and functional studies that solved the atomic structure of HATs and revealed molecular clues on substrate interaction. Moreover, this review focuses on HATs that have a role in the central nervous system (CNS) and that are related to neurological diseases, including: (i) LAT1/CD98hc and its role in the uptake of branched chain amino acids trough the blood brain barrier and autism. (ii) LAT2/CD98hc and its potential role in the transport of glutamine between plasma and cerebrospinal fluid. (iii) y+LAT2/CD98hc that is emerging as a key player in hepatic encephalopathy. xCT/CD98hc as a potential therapeutic target in glioblastoma, and (iv) Asc-1/CD98hc as a potential therapeutic target in pathologies with alterations in NMDA glutamate receptorsSpringer Verlag2025202520212025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion28 p.application/pdfhttps://hdl.handle.net/2445/218666Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1007/s11064-021-03261-wNeurochemical Research, 2021, vol. 47, p. 23-36https://doi.org/10.1007/s11064-021-03261-w(c) Springer Verlag, 2021info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2186662026-05-29T05:05:01Z
dc.title.none.fl_str_mv Heteromeric amino acid transporters in brain: from physiology to pathology
title Heteromeric amino acid transporters in brain: from physiology to pathology
spellingShingle Heteromeric amino acid transporters in brain: from physiology to pathology
Errasti-Murugarren, Ekaitz
Transport biològic
Aminoàcids
Barrera hematoencefàlica
Biological transport
Amino acids
Blood-brain barrier
title_short Heteromeric amino acid transporters in brain: from physiology to pathology
title_full Heteromeric amino acid transporters in brain: from physiology to pathology
title_fullStr Heteromeric amino acid transporters in brain: from physiology to pathology
title_full_unstemmed Heteromeric amino acid transporters in brain: from physiology to pathology
title_sort Heteromeric amino acid transporters in brain: from physiology to pathology
dc.creator.none.fl_str_mv Errasti-Murugarren, Ekaitz
Palacín Prieto, Manuel
author Errasti-Murugarren, Ekaitz
author_facet Errasti-Murugarren, Ekaitz
Palacín Prieto, Manuel
author_role author
author2 Palacín Prieto, Manuel
author2_role author
dc.subject.none.fl_str_mv Transport biològic
Aminoàcids
Barrera hematoencefàlica
Biological transport
Amino acids
Blood-brain barrier
topic Transport biològic
Aminoàcids
Barrera hematoencefàlica
Biological transport
Amino acids
Blood-brain barrier
description In humans, more than 50 transporters are responsible for the traffic and balance of amino acids within and between cells and tissues, and half of them have been associated with disease [1]. Covering all common amino acids, Heteromeric Amino acid Transporters (HATs) are one class of such transporters. This review first highlights structural and functional studies that solved the atomic structure of HATs and revealed molecular clues on substrate interaction. Moreover, this review focuses on HATs that have a role in the central nervous system (CNS) and that are related to neurological diseases, including: (i) LAT1/CD98hc and its role in the uptake of branched chain amino acids trough the blood brain barrier and autism. (ii) LAT2/CD98hc and its potential role in the transport of glutamine between plasma and cerebrospinal fluid. (iii) y+LAT2/CD98hc that is emerging as a key player in hepatic encephalopathy. xCT/CD98hc as a potential therapeutic target in glioblastoma, and (iv) Asc-1/CD98hc as a potential therapeutic target in pathologies with alterations in NMDA glutamate receptors
publishDate 2021
dc.date.none.fl_str_mv 2021
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/218666
url https://hdl.handle.net/2445/218666
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1007/s11064-021-03261-w
Neurochemical Research, 2021, vol. 47, p. 23-36
https://doi.org/10.1007/s11064-021-03261-w
dc.rights.none.fl_str_mv (c) Springer Verlag, 2021
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Verlag, 2021
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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