Immobilized Lipases in the Synthesis of Short-Chain Esters: An Overview of Constraints and Perspectives
Biocatalysis—specifically the use of immobilized lipases—has been proposed as a greener alternative for ester production. Several critical challenges, such as the high cost of biocatalysts, are delaying the industrial implementation of biocatalysis. Moreover, for short-chain ester synthesis, the str...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/391253 |
| Acceso en línea: | http://hdl.handle.net/10261/391253 |
| Access Level: | acceso abierto |
| Palabra clave: | Esters Biocatalysis Lipases Immobilized enzymes Short-chain esters |
| Sumario: | Biocatalysis—specifically the use of immobilized lipases—has been proposed as a greener alternative for ester production. Several critical challenges, such as the high cost of biocatalysts, are delaying the industrial implementation of biocatalysis. Moreover, for short-chain ester synthesis, the strong inhibition/inactivation potential of short-chain acids and alcohols on lipases leads to long reaction cycles and/or the need to use organic solvents to overcome the limitations of solvent-free systems and, consequently, the decrease in product concentrations. This review presents an overview of the scientific developments in enzymatic short-chain ester synthesis, compiling the constraints on their syntheses from a process perspective, including insights about key performance indicators (KPI) and economic parameters. |
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