RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease
We found an unanticipated recovery of several gliosis hallmarks and inflammasome key proteins upon neuronal RTP801 downregulation in the 5xFAD mice. Altogether our results suggest that RTP801 could be a potential future target for theranostic studies since it could be a biomarker of neuroinflammatio...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/207668 |
| Acceso en línea: | https://hdl.handle.net/2445/207668 |
| Access Level: | acceso abierto |
| Palabra clave: | Cervell Mort cel·lular Malaltia d'Alzheimer Malalties cerebrals Proteïnes Brain Cell death Alzheimer's disease Brain diseases Proteins |
| Sumario: | We found an unanticipated recovery of several gliosis hallmarks and inflammasome key proteins upon neuronal RTP801 downregulation in the 5xFAD mice. Altogether our results suggest that RTP801 could be a potential future target for theranostic studies since it could be a biomarker of neuroinflammation and neurotoxicity severity of the disease and, at the same time, a promising therapeutic target in the treatment of AD. |
|---|