Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis

Objectives: To evaluate (1) the association between nailfold capillaroscopy pattern and 5-year risk for incident interstitial lung disease and (2) the association between transition in nailfold capillaroscopy pattern and risk of incident interstitial lung disease. Methods: Data of adult patients fro...

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Autores: Velauthapillai, A, de Vries-Bouwstra, JK, Henes, J, Czirjak, L, Dagna, L, Riemekastan, G, Allanore, Y, Foti, R, Alegre-Sancho, JJ, Maurer, B, Cuomo, G, Spierings, J, Martin, T, Truchetet, ME, van den Ende, CHM, Vonk, MC, EUSTAR Collaborators
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p18311
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/18311
Access Level:acceso abierto
Palabra clave:Systemic sclerosis
interstitial lung disease
nailfold capillaroscopy
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spelling Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysisVelauthapillai, Ade Vries-Bouwstra, JKHenes, JCzirjak, LDagna, LRiemekastan, GAllanore, YFoti, RAlegre-Sancho, JJMaurer, BCuomo, GSpierings, JMartin, TTruchetet, MEvan den Ende, CHMVonk, MCEUSTAR CollaboratorsSystemic sclerosisinterstitial lung diseasenailfold capillaroscopyObjectives: To evaluate (1) the association between nailfold capillaroscopy pattern and 5-year risk for incident interstitial lung disease and (2) the association between transition in nailfold capillaroscopy pattern and risk of incident interstitial lung disease. Methods: Data of adult patients from the EUSTAR database fulfilling the ACR-EULAR criteria with a disease duration <= 5 years, having a scleroderma pattern at nailfold capillaroscopy with high-resolution computed tomography confirmed absence of interstitial lung disease (i.e. baseline) was used. Interstitial lung disease-free survival was assessed for up to 5 years of follow-up with a Cox proportional hazards model stratified on nailfold capillaroscopy pattern at baseline. The association of annual transition in nailfold capillaroscopy pattern on the risk to develop interstitial lung disease was assessed with a mixed logistic regression analysis. Results: Out of 771 eligible patients, 283 (37%) had an early pattern, 377 (49%) had an active pattern, and 111 (14%) had a late pattern. The Cox proportional hazard model including the identified confounders did not show an association between severity of nailfold capillaroscopy pattern at baseline and increased risk for interstitial lung disease during 5-year follow-up (hazard ratio (95 confidence interval; p value): 1.09 (0.86-1.39; 0.47)). The mixed logistic regression analysis revealed an increased annual risk for incident interstitial lung disease with increasing severity of capillaroscopic pattern (odds ratio (95% confidence interval); p value 3.76 (1.99-7.11; <0.01)). Conclusion: Our study shows that worsening of nailfold capillaroscopy has a strong association with an increased annual risk to develop interstitial lung disease. Of note, a worse scleroderma pattern at nailfold capillaroscopy is not associated with the long-term risk to develop interstitial lung disease.SAGE PUBLICATIONS LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/18311Journal of Scleroderma and Related DisordersISSN: 23971983ISSNe: 23971991reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p183112026-06-11T12:45:17Z
dc.title.none.fl_str_mv Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
title Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
spellingShingle Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
Velauthapillai, A
Systemic sclerosis
interstitial lung disease
nailfold capillaroscopy
title_short Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
title_full Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
title_fullStr Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
title_full_unstemmed Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
title_sort Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
dc.creator.none.fl_str_mv Velauthapillai, A
de Vries-Bouwstra, JK
Henes, J
Czirjak, L
Dagna, L
Riemekastan, G
Allanore, Y
Foti, R
Alegre-Sancho, JJ
Maurer, B
Cuomo, G
Spierings, J
Martin, T
Truchetet, ME
van den Ende, CHM
Vonk, MC
EUSTAR Collaborators
author Velauthapillai, A
author_facet Velauthapillai, A
de Vries-Bouwstra, JK
Henes, J
Czirjak, L
Dagna, L
Riemekastan, G
Allanore, Y
Foti, R
Alegre-Sancho, JJ
Maurer, B
Cuomo, G
Spierings, J
Martin, T
Truchetet, ME
van den Ende, CHM
Vonk, MC
EUSTAR Collaborators
author_role author
author2 de Vries-Bouwstra, JK
Henes, J
Czirjak, L
Dagna, L
Riemekastan, G
Allanore, Y
Foti, R
Alegre-Sancho, JJ
Maurer, B
Cuomo, G
Spierings, J
Martin, T
Truchetet, ME
van den Ende, CHM
Vonk, MC
EUSTAR Collaborators
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Systemic sclerosis
interstitial lung disease
nailfold capillaroscopy
topic Systemic sclerosis
interstitial lung disease
nailfold capillaroscopy
description Objectives: To evaluate (1) the association between nailfold capillaroscopy pattern and 5-year risk for incident interstitial lung disease and (2) the association between transition in nailfold capillaroscopy pattern and risk of incident interstitial lung disease. Methods: Data of adult patients from the EUSTAR database fulfilling the ACR-EULAR criteria with a disease duration <= 5 years, having a scleroderma pattern at nailfold capillaroscopy with high-resolution computed tomography confirmed absence of interstitial lung disease (i.e. baseline) was used. Interstitial lung disease-free survival was assessed for up to 5 years of follow-up with a Cox proportional hazards model stratified on nailfold capillaroscopy pattern at baseline. The association of annual transition in nailfold capillaroscopy pattern on the risk to develop interstitial lung disease was assessed with a mixed logistic regression analysis. Results: Out of 771 eligible patients, 283 (37%) had an early pattern, 377 (49%) had an active pattern, and 111 (14%) had a late pattern. The Cox proportional hazard model including the identified confounders did not show an association between severity of nailfold capillaroscopy pattern at baseline and increased risk for interstitial lung disease during 5-year follow-up (hazard ratio (95 confidence interval; p value): 1.09 (0.86-1.39; 0.47)). The mixed logistic regression analysis revealed an increased annual risk for incident interstitial lung disease with increasing severity of capillaroscopic pattern (odds ratio (95% confidence interval); p value 3.76 (1.99-7.11; <0.01)). Conclusion: Our study shows that worsening of nailfold capillaroscopy has a strong association with an increased annual risk to develop interstitial lung disease. Of note, a worse scleroderma pattern at nailfold capillaroscopy is not associated with the long-term risk to develop interstitial lung disease.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/18311
url https://fisabio.portalinvestigacion.com/publicaciones/18311
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
dc.source.none.fl_str_mv Journal of Scleroderma and Related Disorders
ISSN: 23971983
ISSNe: 23971991
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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