Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.

Even relatively low levels of metals exposure may impact health, particularly among vulnerable populations such as infants and young children. However, little is known about the interplay between simultaneous metal exposures, common in real-life scenarios, and their association with specific dietary...

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Autores: Notario-Barandiaran L, Irizar A, Begoña-Zubero M, Soler-Blasco R, Riutort-Mayol G, Fernández-Somoano A, Tardón A, Casas M, Vrijheid M, Meharg A, Carey M, Meharg C, Ralphs K, McCreanor C, Grimalt JO, Vioque J, Signes-Pastor AJ
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p9838
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones9838
https://www.sciencedirect.com/science/article/pii/S0013935123013129?via%3Dihub
Access Level:acceso abierto
Palabra clave:Arsenic speciation
Children
Mediterranean diet
Metals
aMED
rMED
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spelling Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.Notario-Barandiaran LIrizar ABegoña-Zubero MSoler-Blasco RRiutort-Mayol GFernández-Somoano ATardón ACasas MVrijheid MMeharg ACarey MMeharg CRalphs KMcCreanor CGrimalt JOVioque JSignes-Pastor AJArsenic speciationChildrenMediterranean dietMetalsaMEDrMEDEven relatively low levels of metals exposure may impact health, particularly among vulnerable populations such as infants and young children. However, little is known about the interplay between simultaneous metal exposures, common in real-life scenarios, and their association with specific dietary patterns. In this study, we have evaluated the association between adherence to Mediterranean diet (MD) and urinary metal concentrations individually and as an exposure mixture in 713 children aged 4-5-years from the INMA cohort study. We used a validated food frequency questionnaire to calculate two MD indexes scores: aMED and rMED. These indexes gather information on various food groups within the MD and score differently. To measure urinary concentrations of cobalt, copper, zinc, molybdenum, selenium, lead, and cadmium as exposure biomarkers, we used inductively coupled plasma mass spectrometry (ICP-MS), coupled with an ion chromatography (IC) equipment for arsenic speciation analysis. We applied linear regression and quantile g-computation, adjusted for confounders, to analyse the association between MD adherence and exposure to the metal mixture. High adherence to MD such as the quintile (Q) 5 MD was associated with higher urinary arsenobetaine (AsB) levels than Q1, with ß values of 0.55 (confidence interval - CI 95% 0.01; 1.09) for aMED and 0.73 (CI 95% 0.13; 1.33) for rMED. Consumption of fish was associated with increased urinary AsB but reduced inorganic arsenic concentrations. In contrast, the aMED vegetables consumption increased urinary inorganic arsenic content. A moderate level of adherence to MD (Q2 and Q3) was associated with lower copper urinary concentrations than Q1, with ß values of -0.42 (CI 95% -0.72; -0.11) for Q2 and -0.33 (CI 95% -0.63; -0.02) for Q3, but only with aMED. Our study, conducted in Spain, revealed that adhering to the MD reduces exposure to certain metals while increasing exposure to others. Specifically, we observed increase in exposure to non-toxic AsB, highlighting the significance of consuming fish/seafood. However, it is crucial to emphasize the necessity for additional efforts in reducing early-life exposure to toxic metals, even when adhering to certain food components of the MD.ACADEMIC PRESS INC ELSEVIER SCIENCE2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones9838https://www.sciencedirect.com/science/article/pii/S0013935123013129?via%3DihubENVIRONMENTAL RESEARCHISSN: 00139351ISSNe: 10960953reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p98382026-06-12T10:20:37Z
dc.title.none.fl_str_mv Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.
title Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.
spellingShingle Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.
Notario-Barandiaran L
Arsenic speciation
Children
Mediterranean diet
Metals
aMED
rMED
title_short Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.
title_full Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.
title_fullStr Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.
title_full_unstemmed Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.
title_sort Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.
dc.creator.none.fl_str_mv Notario-Barandiaran L
Irizar A
Begoña-Zubero M
Soler-Blasco R
Riutort-Mayol G
Fernández-Somoano A
Tardón A
Casas M
Vrijheid M
Meharg A
Carey M
Meharg C
Ralphs K
McCreanor C
Grimalt JO
Vioque J
Signes-Pastor AJ
author Notario-Barandiaran L
author_facet Notario-Barandiaran L
Irizar A
Begoña-Zubero M
Soler-Blasco R
Riutort-Mayol G
Fernández-Somoano A
Tardón A
Casas M
Vrijheid M
Meharg A
Carey M
Meharg C
Ralphs K
McCreanor C
Grimalt JO
Vioque J
Signes-Pastor AJ
author_role author
author2 Irizar A
Begoña-Zubero M
Soler-Blasco R
Riutort-Mayol G
Fernández-Somoano A
Tardón A
Casas M
Vrijheid M
Meharg A
Carey M
Meharg C
Ralphs K
McCreanor C
Grimalt JO
Vioque J
Signes-Pastor AJ
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Arsenic speciation
Children
Mediterranean diet
Metals
aMED
rMED
topic Arsenic speciation
Children
Mediterranean diet
Metals
aMED
rMED
description Even relatively low levels of metals exposure may impact health, particularly among vulnerable populations such as infants and young children. However, little is known about the interplay between simultaneous metal exposures, common in real-life scenarios, and their association with specific dietary patterns. In this study, we have evaluated the association between adherence to Mediterranean diet (MD) and urinary metal concentrations individually and as an exposure mixture in 713 children aged 4-5-years from the INMA cohort study. We used a validated food frequency questionnaire to calculate two MD indexes scores: aMED and rMED. These indexes gather information on various food groups within the MD and score differently. To measure urinary concentrations of cobalt, copper, zinc, molybdenum, selenium, lead, and cadmium as exposure biomarkers, we used inductively coupled plasma mass spectrometry (ICP-MS), coupled with an ion chromatography (IC) equipment for arsenic speciation analysis. We applied linear regression and quantile g-computation, adjusted for confounders, to analyse the association between MD adherence and exposure to the metal mixture. High adherence to MD such as the quintile (Q) 5 MD was associated with higher urinary arsenobetaine (AsB) levels than Q1, with ß values of 0.55 (confidence interval - CI 95% 0.01; 1.09) for aMED and 0.73 (CI 95% 0.13; 1.33) for rMED. Consumption of fish was associated with increased urinary AsB but reduced inorganic arsenic concentrations. In contrast, the aMED vegetables consumption increased urinary inorganic arsenic content. A moderate level of adherence to MD (Q2 and Q3) was associated with lower copper urinary concentrations than Q1, with ß values of -0.42 (CI 95% -0.72; -0.11) for Q2 and -0.33 (CI 95% -0.63; -0.02) for Q3, but only with aMED. Our study, conducted in Spain, revealed that adhering to the MD reduces exposure to certain metals while increasing exposure to others. Specifically, we observed increase in exposure to non-toxic AsB, highlighting the significance of consuming fish/seafood. However, it is crucial to emphasize the necessity for additional efforts in reducing early-life exposure to toxic metals, even when adhering to certain food components of the MD.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones9838
https://www.sciencedirect.com/science/article/pii/S0013935123013129?via%3Dihub
url https://isabial.portalinvestigacion.com/publicaciones9838
https://www.sciencedirect.com/science/article/pii/S0013935123013129?via%3Dihub
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ACADEMIC PRESS INC ELSEVIER SCIENCE
publisher.none.fl_str_mv ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.source.none.fl_str_mv ENVIRONMENTAL RESEARCH
ISSN: 00139351
ISSNe: 10960953
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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