Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population

Background: The DSM-5 diagnostic criteria for Prescription Opioid-Use Disorder (POUD) have undergone some significant changes. One of the most controversial changes has been the elimination of the withdrawal symptoms criterion when opioid use is under appropriate medical supervision. For this reason...

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Autores: Rodriguez-Espinosa, S, Coloma-Carmona, A, Perez-Carbonell, A, Roman-Quiles, JF, Carballo, JL
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p11729
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/11729
Access Level:acceso abierto
Palabra clave:Chronic pain
Prescription Opioid-Use Disorder
Withdrawal symptoms
DSM-5
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spelling Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain populationRodriguez-Espinosa, SColoma-Carmona, APerez-Carbonell, ARoman-Quiles, JFCarballo, JLChronic painPrescription Opioid-Use DisorderWithdrawal symptomsDSM-5Background: The DSM-5 diagnostic criteria for Prescription Opioid-Use Disorder (POUD) have undergone some significant changes. One of the most controversial changes has been the elimination of the withdrawal symptoms criterion when opioid use is under appropriate medical supervision. For this reason, the goal of this study was to analyze factors associated with opioid withdrawal in patients with chronic non-cancer pain (CNCP). Methods: This cross-sectional descriptive study involved 404 patients who use prescription opioids for long-term treatment (>90 days) of CNCP. Measures included sociodemographic and clinical characteristics, POUD, withdrawal symptoms, craving, anxiety-depressive symptoms, and pain intensity and interference. Results: Forty-seven percent (n = 193) of the sample reported moderate-severe withdrawal symptoms, which were associated with lower age, higher daily morphine dose and duration of treatment with opioids, moderatesevere POUD, use of psychotropic drugs, higher anxiety-depressive symptoms, and greater pain intensity and interference (p < .05). Binary logistic regression analysis showed that moderate-severe POUD (OR = 2.82), anxiety (OR = 2.21), depression (OR = 1.81), higher pain interference (OR = 1.05), and longer duration of treatment with opioids were the strongest factors associated with moderate-severe withdrawal symptoms (p < .05). Conclusion: Psychological factors seem to play a key role in the severity of withdrawal symptoms. Since greater intensity of these symptoms increases the risk of developing POUD, knowing the factors associated with withdrawal may be useful in developing preventive psychological interventions.Elsevier Inc.2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/11729Journal of Substance Abuse TreatmentISSN: 18736483ISSNe: 07405472reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p117292026-06-11T12:45:17Z
dc.title.none.fl_str_mv Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population
title Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population
spellingShingle Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population
Rodriguez-Espinosa, S
Chronic pain
Prescription Opioid-Use Disorder
Withdrawal symptoms
DSM-5
title_short Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population
title_full Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population
title_fullStr Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population
title_full_unstemmed Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population
title_sort Clinical and psychological factors associated with interdose opioid withdrawal in chronic pain population
dc.creator.none.fl_str_mv Rodriguez-Espinosa, S
Coloma-Carmona, A
Perez-Carbonell, A
Roman-Quiles, JF
Carballo, JL
author Rodriguez-Espinosa, S
author_facet Rodriguez-Espinosa, S
Coloma-Carmona, A
Perez-Carbonell, A
Roman-Quiles, JF
Carballo, JL
author_role author
author2 Coloma-Carmona, A
Perez-Carbonell, A
Roman-Quiles, JF
Carballo, JL
author2_role author
author
author
author
dc.subject.none.fl_str_mv Chronic pain
Prescription Opioid-Use Disorder
Withdrawal symptoms
DSM-5
topic Chronic pain
Prescription Opioid-Use Disorder
Withdrawal symptoms
DSM-5
description Background: The DSM-5 diagnostic criteria for Prescription Opioid-Use Disorder (POUD) have undergone some significant changes. One of the most controversial changes has been the elimination of the withdrawal symptoms criterion when opioid use is under appropriate medical supervision. For this reason, the goal of this study was to analyze factors associated with opioid withdrawal in patients with chronic non-cancer pain (CNCP). Methods: This cross-sectional descriptive study involved 404 patients who use prescription opioids for long-term treatment (>90 days) of CNCP. Measures included sociodemographic and clinical characteristics, POUD, withdrawal symptoms, craving, anxiety-depressive symptoms, and pain intensity and interference. Results: Forty-seven percent (n = 193) of the sample reported moderate-severe withdrawal symptoms, which were associated with lower age, higher daily morphine dose and duration of treatment with opioids, moderatesevere POUD, use of psychotropic drugs, higher anxiety-depressive symptoms, and greater pain intensity and interference (p < .05). Binary logistic regression analysis showed that moderate-severe POUD (OR = 2.82), anxiety (OR = 2.21), depression (OR = 1.81), higher pain interference (OR = 1.05), and longer duration of treatment with opioids were the strongest factors associated with moderate-severe withdrawal symptoms (p < .05). Conclusion: Psychological factors seem to play a key role in the severity of withdrawal symptoms. Since greater intensity of these symptoms increases the risk of developing POUD, knowing the factors associated with withdrawal may be useful in developing preventive psychological interventions.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/11729
url https://fisabio.portalinvestigacion.com/publicaciones/11729
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Inc.
publisher.none.fl_str_mv Elsevier Inc.
dc.source.none.fl_str_mv Journal of Substance Abuse Treatment
ISSN: 18736483
ISSNe: 07405472
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
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reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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