A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping

This is a copy of the author 's final draft version of an article published in the journal Analytical and bioanalytical chemistry. The final publication is available at Springer via http://dx.doi.org/10.1007/s00216-016-9629-2

Detalles Bibliográficos
Autores: Mohammadi, Mahdi, Javad Zare, Mohammad, Madadi, Hojjat, Sellarès González, Jordi|||0000-0001-7525-3166, Casals Terré, Jasmina|||0000-0002-1368-3950
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/102366
Acceso en línea:https://hdl.handle.net/2117/102366
https://dx.doi.org/10.1007/s00216-016-9629-2
Access Level:acceso abierto
Palabra clave:Dielectrophoresis
Modeling
Insulator-based dielectrophoresis
Particle trapping
Dielectroforesi
Àrees temàtiques de la UPC::Física::Física de l'estat sòlid::Dielèctrics
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spelling A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trappingMohammadi, MahdiJavad Zare, MohammadMadadi, HojjatSellarès González, Jordi|||0000-0001-7525-3166Casals Terré, Jasmina|||0000-0002-1368-3950DielectrophoresisDielectrophoresisModelingInsulator-based dielectrophoresisParticle trappingDielectroforesiÀrees temàtiques de la UPC::Física::Física de l'estat sòlid::DielèctricsThis is a copy of the author 's final draft version of an article published in the journal Analytical and bioanalytical chemistry. The final publication is available at Springer via http://dx.doi.org/10.1007/s00216-016-9629-2Direct-current insulator-based dielectrophoresis (DC-iDEP) is a well-known technique that benefits from the electric field gradients generated by an array of insulating posts to separate or trap biological particles. The aim of this study is to provide a first geometrical relationship of the post array that independent of the particles and/or medium, maximizes the trapping. A novel figure of merit is proposed to maximize the particle trapping in the post array while minimizing the required voltage, with a similar footprint and channel thickness. Different post array models with the variation of transversal distance (10 to 60 µm), longitudinal distance (10 to 80 µm), and post radius (10 to 150 µm) were analyzed using COMSOL Multiphysics finite element software. The obtained results indicated that a post radius of 40 µm larger than the transversal distance between posts could enhance the trapping condition between 56 % (for a transversal distance of 10 µm) and 341 % (for a transversal distance of 60 µm). For the validation of the numerical results, several microchannels with embedded post arrays were manufactured in polydimethylsiloxane (PDMS) and the particle trapping patterns of 6-µm-diameter polystyrene particles were measured experimentally. The experiments confirm the same trends as pointed out by the numerical analysis. The results show that this new figure of merit and geometrical relationship can be used to reduce the required electric field to achieve effective particle trapping and, therefore, avoid the negative effects of Joule heating in cells or viable particles. The main advantage of these results is that they depend only on the geometry of the micropost array and are valid for trapping different particles suspended in different media.Peer Reviewed20162016-07-0120172017-03-13journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/102366https://dx.doi.org/10.1007/s00216-016-9629-2reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1023662026-05-27T15:37:01Z
dc.title.none.fl_str_mv A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping
title A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping
spellingShingle A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping
Mohammadi, Mahdi
Dielectrophoresis
Dielectrophoresis
Modeling
Insulator-based dielectrophoresis
Particle trapping
Dielectroforesi
Àrees temàtiques de la UPC::Física::Física de l'estat sòlid::Dielèctrics
title_short A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping
title_full A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping
title_fullStr A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping
title_full_unstemmed A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping
title_sort A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping
dc.creator.none.fl_str_mv Mohammadi, Mahdi
Javad Zare, Mohammad
Madadi, Hojjat
Sellarès González, Jordi|||0000-0001-7525-3166
Casals Terré, Jasmina|||0000-0002-1368-3950
author Mohammadi, Mahdi
author_facet Mohammadi, Mahdi
Javad Zare, Mohammad
Madadi, Hojjat
Sellarès González, Jordi|||0000-0001-7525-3166
Casals Terré, Jasmina|||0000-0002-1368-3950
author_role author
author2 Javad Zare, Mohammad
Madadi, Hojjat
Sellarès González, Jordi|||0000-0001-7525-3166
Casals Terré, Jasmina|||0000-0002-1368-3950
author2_role author
author
author
author
dc.subject.none.fl_str_mv Dielectrophoresis
Dielectrophoresis
Modeling
Insulator-based dielectrophoresis
Particle trapping
Dielectroforesi
Àrees temàtiques de la UPC::Física::Física de l'estat sòlid::Dielèctrics
topic Dielectrophoresis
Dielectrophoresis
Modeling
Insulator-based dielectrophoresis
Particle trapping
Dielectroforesi
Àrees temàtiques de la UPC::Física::Física de l'estat sòlid::Dielèctrics
description This is a copy of the author 's final draft version of an article published in the journal Analytical and bioanalytical chemistry. The final publication is available at Springer via http://dx.doi.org/10.1007/s00216-016-9629-2
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-07-01
2017
2017-03-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/102366
https://dx.doi.org/10.1007/s00216-016-9629-2
url https://hdl.handle.net/2117/102366
https://dx.doi.org/10.1007/s00216-016-9629-2
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408936329740288
score 15,301603

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