Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

Mena-Vazquez, N.; Fernandez-Nebro, A.; Pego Reigosa, José María; Galindo, M.; Melissa-Anzola, A.; Uriarte-Isacelay, E.; Olive-Marques, A.; Aurrecoechea, E.; Freire, M.; Tomero, E.; Garcia-Villanueva, M. J.; Stoye, C.; Salas-Heredia, E.; Bernal-Vidal, J. A.; Salgado Pérez, Eva; Blanco, R.; Javier Novoa, F.; Ibanez-Barcelo, M.; Torrente-Segarra, V.; Narvaez, J.; Calvet, J.; Moriano Morales, C.; Ramon Vazquez-Rodriguez, T.; Garcia de la Pena, P.; Bohorquez, C.; Andreu-Sanchez, J. L.; Cobo-Ibanez, T.; Bonilla, G.; Lozano-Rivas, N.; Montilla, C.; Toyos, F. J.; De la Fuente, J. L. M.; Exposito, L.; Ruiz-Lucea, M. E.; Vals, E.; Manero-Ruiz, J.; Rua-Figueroa, I.

Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

OBJECTIVES: This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. METHODS: RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-s...

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Autores:	Mena-Vazquez, N., Fernandez-Nebro, A., Pego Reigosa, José María, Galindo, M., Melissa-Anzola, A., Uriarte-Isacelay, E., Olive-Marques, A., Aurrecoechea, E., Freire, M., Tomero, E., Garcia-Villanueva, M. J., Stoye, C., Salas-Heredia, E., Bernal-Vidal, J. A., Salgado Pérez, Eva, Blanco, R., Javier Novoa, F., Ibanez-Barcelo, M., Torrente-Segarra, V., Narvaez, J., Calvet, J., Moriano Morales, C., Ramon Vazquez-Rodriguez, T., Garcia de la Pena, P., Bohorquez, C., Andreu-Sanchez, J. L., Cobo-Ibanez, T., Bonilla, G., Lozano-Rivas, N., Montilla, C., Toyos, F. J., De la Fuente, J. L. M., Exposito, L., Ruiz-Lucea, M. E., Vals, E., Manero-Ruiz, J., Rua-Figueroa, I.
Tipo de recurso:	artículo
Fecha de publicación:	2019
País:	España
Institución:	Servizo Galego de Saúde (SERGAS)
Repositorio:	RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:	oai:runa.sergas.gal:20.500.11940/15962
Acceso en línea:	http://diposit.ub.edu/dspace/bitstream/2445/171742/1/Mena-VazquezN.pdf https://www.ncbi.nlm.nih.gov/pubmed/31808534 http://hdl.handle.net/20.500.11940/15962
Access Level:	acceso abierto
Palabra clave:	Adult Middle Aged Humans Registries Antirheumatic Agents Cross-Sectional Studies Young Adult Autoimmune Diseases Hydroxychloroquine Autoimmunity autoinmunidad adulto joven mediana edad humanos estudios transversales antirreumáticos adulto sistema de registros hidroxicloroquina enfermedades autoinmunes CHUO CHUVI

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network_acronym_str	ES
network_name_str	España
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spelling	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER RegistryMena-Vazquez, N.Fernandez-Nebro, A.Pego Reigosa, José MaríaGalindo, M.Melissa-Anzola, A.Uriarte-Isacelay, E.Olive-Marques, A.Aurrecoechea, E.Freire, M.Tomero, E.Garcia-Villanueva, M. J.Stoye, C.Salas-Heredia, E.Bernal-Vidal, J. A.Salgado Pérez, EvaBlanco, R.Javier Novoa, F.Ibanez-Barcelo, M.Torrente-Segarra, V.Narvaez, J.Calvet, J.Moriano Morales, C.Ramon Vazquez-Rodriguez, T.Garcia de la Pena, P.Bohorquez, C.Andreu-Sanchez, J. L.Cobo-Ibanez, T.Bonilla, G.Lozano-Rivas, N.Montilla, C.Toyos, F. J.De la Fuente, J. L. M.Exposito, L.Ruiz-Lucea, M. E.Vals, E.Manero-Ruiz, J.Bernal-Vidal, J. A.Rua-Figueroa, I.AdultMiddle AgedHumansRegistriesAntirheumatic AgentsCross-Sectional StudiesYoung AdultAutoimmune DiseasesHydroxychloroquineAutoimmunityautoinmunidadadulto jovenmediana edadhumanosestudios transversalesantirreumáticosadultosistema de registroshidroxicloroquinaenfermedades autoinmunesCHUOCHUVIOBJECTIVES: This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. METHODS: RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. RESULTS: Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. CONCLUSION: Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies.2019info:eu-repo/semantics/articlehttp://diposit.ub.edu/dspace/bitstream/2445/171742/1/Mena-VazquezN.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/31808534http://hdl.handle.net/20.500.11940/15962reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/159622026-06-12T08:40:47Z
dc.title.none.fl_str_mv	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
spellingShingle	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry Mena-Vazquez, N. Adult Middle Aged Humans Registries Antirheumatic Agents Cross-Sectional Studies Young Adult Autoimmune Diseases Hydroxychloroquine Autoimmunity autoinmunidad adulto joven mediana edad humanos estudios transversales antirreumáticos adulto sistema de registros hidroxicloroquina enfermedades autoinmunes CHUO CHUVI
title_short	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title_full	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title_fullStr	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title_full_unstemmed	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title_sort	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
dc.creator.none.fl_str_mv	Mena-Vazquez, N. Fernandez-Nebro, A. Pego Reigosa, José María Galindo, M. Melissa-Anzola, A. Uriarte-Isacelay, E. Olive-Marques, A. Aurrecoechea, E. Freire, M. Tomero, E. Garcia-Villanueva, M. J. Stoye, C. Salas-Heredia, E. Bernal-Vidal, J. A. Salgado Pérez, Eva Blanco, R. Javier Novoa, F. Ibanez-Barcelo, M. Torrente-Segarra, V. Narvaez, J. Calvet, J. Moriano Morales, C. Ramon Vazquez-Rodriguez, T. Garcia de la Pena, P. Bohorquez, C. Andreu-Sanchez, J. L. Cobo-Ibanez, T. Bonilla, G. Lozano-Rivas, N. Montilla, C. Toyos, F. J. De la Fuente, J. L. M. Exposito, L. Ruiz-Lucea, M. E. Vals, E. Manero-Ruiz, J. Bernal-Vidal, J. A. Rua-Figueroa, I.
author	Mena-Vazquez, N.
author_facet	Mena-Vazquez, N. Fernandez-Nebro, A. Pego Reigosa, José María Galindo, M. Melissa-Anzola, A. Uriarte-Isacelay, E. Olive-Marques, A. Aurrecoechea, E. Freire, M. Tomero, E. Garcia-Villanueva, M. J. Stoye, C. Salas-Heredia, E. Bernal-Vidal, J. A. Salgado Pérez, Eva Blanco, R. Javier Novoa, F. Ibanez-Barcelo, M. Torrente-Segarra, V. Narvaez, J. Calvet, J. Moriano Morales, C. Ramon Vazquez-Rodriguez, T. Garcia de la Pena, P. Bohorquez, C. Andreu-Sanchez, J. L. Cobo-Ibanez, T. Bonilla, G. Lozano-Rivas, N. Montilla, C. Toyos, F. J. De la Fuente, J. L. M. Exposito, L. Ruiz-Lucea, M. E. Vals, E. Manero-Ruiz, J. Rua-Figueroa, I.
author_role	author
author2	Fernandez-Nebro, A. Pego Reigosa, José María Galindo, M. Melissa-Anzola, A. Uriarte-Isacelay, E. Olive-Marques, A. Aurrecoechea, E. Freire, M. Tomero, E. Garcia-Villanueva, M. J. Stoye, C. Salas-Heredia, E. Bernal-Vidal, J. A. Salgado Pérez, Eva Blanco, R. Javier Novoa, F. Ibanez-Barcelo, M. Torrente-Segarra, V. Narvaez, J. Calvet, J. Moriano Morales, C. Ramon Vazquez-Rodriguez, T. Garcia de la Pena, P. Bohorquez, C. Andreu-Sanchez, J. L. Cobo-Ibanez, T. Bonilla, G. Lozano-Rivas, N. Montilla, C. Toyos, F. J. De la Fuente, J. L. M. Exposito, L. Ruiz-Lucea, M. E. Vals, E. Manero-Ruiz, J. Rua-Figueroa, I.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Adult Middle Aged Humans Registries Antirheumatic Agents Cross-Sectional Studies Young Adult Autoimmune Diseases Hydroxychloroquine Autoimmunity autoinmunidad adulto joven mediana edad humanos estudios transversales antirreumáticos adulto sistema de registros hidroxicloroquina enfermedades autoinmunes CHUO CHUVI
topic	Adult Middle Aged Humans Registries Antirheumatic Agents Cross-Sectional Studies Young Adult Autoimmune Diseases Hydroxychloroquine Autoimmunity autoinmunidad adulto joven mediana edad humanos estudios transversales antirreumáticos adulto sistema de registros hidroxicloroquina enfermedades autoinmunes CHUO CHUVI
description	OBJECTIVES: This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. METHODS: RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. RESULTS: Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. CONCLUSION: Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies.
publishDate	2019
dc.date.none.fl_str_mv	2019
dc.type.none.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://diposit.ub.edu/dspace/bitstream/2445/171742/1/Mena-VazquezN.pdf https://www.ncbi.nlm.nih.gov/pubmed/31808534 http://hdl.handle.net/20.500.11940/15962
url	http://diposit.ub.edu/dspace/bitstream/2445/171742/1/Mena-VazquezN.pdf https://www.ncbi.nlm.nih.gov/pubmed/31808534 http://hdl.handle.net/20.500.11940/15962
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas instname:Servizo Galego de Saúde (SERGAS)
instname_str	Servizo Galego de Saúde (SERGAS)
reponame_str	RUNA. Repositorio da Consellería de Sanidade e Sergas
collection	RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

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