Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode

Aim: To analyze the clinical, neurocognitive, and functional impact of prolactin levels according to sex in patients with a First Episode Psychosis (FEP). Methods: We measured prolactin levels in 221 non-affective FEP patients treated with antipsychotics (AP) and 224 healthy controls, at baseline an...

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Autores: Jordà-Baleri, Teresa, Garriga, Marina, Mezquida, Gisela, Cuesta, Manuel J., Martínez-Aran, Anabel, García-Rizo, Clemente, Lobo, Antonio, González Pinto, Ana, Díaz-Caneja, Covadonga M., Roldán, Alexandra, Vieta, Eduard, Baeza, Inmaculada, Trabsa, Amira, Montalvo, Itziar, Tortorella, Alfonso, Menculini, Giulia, Verdolini, Norma, Ramos-Quiroga, Josep Antoni, Sánchez Torres, Ana María, Bernardo, Miguel, Amoretti, Silvia, PEPs Group
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/52406
Acceso en línea:https://hdl.handle.net/2454/52406
Access Level:acceso abierto
Palabra clave:First-episode psychosis
Functioning
Negative symptoms
Prolactin
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spelling Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episodeJordà-Baleri, TeresaGarriga, MarinaMezquida, GiselaCuesta, Manuel J.Martínez-Aran, AnabelGarcía-Rizo, ClementeLobo, AntonioGonzález Pinto, AnaDíaz-Caneja, Covadonga M.Roldán, AlexandraVieta, EduardBaeza, InmaculadaTrabsa, AmiraMontalvo, ItziarTortorella, AlfonsoMenculini, GiuliaVerdolini, NormaRamos-Quiroga, Josep AntoniSánchez Torres, Ana MaríaBernardo, MiguelAmoretti, SilviaPEPs GroupFirst-episode psychosisFunctioningNegative symptomsProlactinAim: To analyze the clinical, neurocognitive, and functional impact of prolactin levels according to sex in patients with a First Episode Psychosis (FEP). Methods: We measured prolactin levels in 221 non-affective FEP patients treated with antipsychotics (AP) and 224 healthy controls, at baseline and 2-year follow-up. We examined whether the relationships between clinical and functional variables were mediated by prolactin, controlling for antipsychotic use, according to sex. Results: Prolactin levels were higher in patients when compared to controls at both time points. Baseline factors associated with prolactin were chlorpromazine equivalents, attention, and executive functioning. In the FEP group, prolactin levels were associated with functioning and diminished expression in males, and with working memory in females. Prolactin levels (p=0.0134) played a role as a mediator between negative symptomatology (p=0.086) and functional outcome (p=0.008) only in FEP male patients at baseline. Conclusions: Prolactin plays a role in the functionality and clinical symptomatology of FEP patients. Our results suggest that pharmacological counselling in patients with hyperprolactinemia at baseline and negative symptomatology might improve their functional and clinical outcomes.This study is part of a coordinated-multicentre Project, funded by the Ministerio de Economía y Competitividad (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III -Fondo Europeo de Desarrollo Regional. Unión Europea. Una manera de hacer Europa, Centro de Investigación Biomédica en Red de salud Mental, CIBERSAM, by the CERCA Programme / Generalitat de Catalunya AND Secretaria d'Universitats i Recerca del Departament d'Economia I Coneixement (2021SGR 01120). This work was supported by La Marató-TV3 Foundation grants 202234-30 (to E. Vieta), 202234-32 (to S. Amoretti) and 202205-10 (to M. Bernardo).ElsevierCiencias de la SaludOsasun Zientziak2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/mswordhttps://hdl.handle.net/2454/52406reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement///PI08%2F0208info:eu-repo/grantAgreement/MICINN//PI11%2F00325info:eu-repo/grantAgreement/MINECO//PI14%2F00612© 2024 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/524062026-06-17T12:41:47Z
dc.title.none.fl_str_mv Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
title Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
spellingShingle Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
Jordà-Baleri, Teresa
First-episode psychosis
Functioning
Negative symptoms
Prolactin
title_short Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
title_full Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
title_fullStr Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
title_full_unstemmed Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
title_sort Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
dc.creator.none.fl_str_mv Jordà-Baleri, Teresa
Garriga, Marina
Mezquida, Gisela
Cuesta, Manuel J.
Martínez-Aran, Anabel
García-Rizo, Clemente
Lobo, Antonio
González Pinto, Ana
Díaz-Caneja, Covadonga M.
Roldán, Alexandra
Vieta, Eduard
Baeza, Inmaculada
Trabsa, Amira
Montalvo, Itziar
Tortorella, Alfonso
Menculini, Giulia
Verdolini, Norma
Ramos-Quiroga, Josep Antoni
Sánchez Torres, Ana María
Bernardo, Miguel
Amoretti, Silvia
PEPs Group
author Jordà-Baleri, Teresa
author_facet Jordà-Baleri, Teresa
Garriga, Marina
Mezquida, Gisela
Cuesta, Manuel J.
Martínez-Aran, Anabel
García-Rizo, Clemente
Lobo, Antonio
González Pinto, Ana
Díaz-Caneja, Covadonga M.
Roldán, Alexandra
Vieta, Eduard
Baeza, Inmaculada
Trabsa, Amira
Montalvo, Itziar
Tortorella, Alfonso
Menculini, Giulia
Verdolini, Norma
Ramos-Quiroga, Josep Antoni
Sánchez Torres, Ana María
Bernardo, Miguel
Amoretti, Silvia
PEPs Group
author_role author
author2 Garriga, Marina
Mezquida, Gisela
Cuesta, Manuel J.
Martínez-Aran, Anabel
García-Rizo, Clemente
Lobo, Antonio
González Pinto, Ana
Díaz-Caneja, Covadonga M.
Roldán, Alexandra
Vieta, Eduard
Baeza, Inmaculada
Trabsa, Amira
Montalvo, Itziar
Tortorella, Alfonso
Menculini, Giulia
Verdolini, Norma
Ramos-Quiroga, Josep Antoni
Sánchez Torres, Ana María
Bernardo, Miguel
Amoretti, Silvia
PEPs Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv First-episode psychosis
Functioning
Negative symptoms
Prolactin
topic First-episode psychosis
Functioning
Negative symptoms
Prolactin
description Aim: To analyze the clinical, neurocognitive, and functional impact of prolactin levels according to sex in patients with a First Episode Psychosis (FEP). Methods: We measured prolactin levels in 221 non-affective FEP patients treated with antipsychotics (AP) and 224 healthy controls, at baseline and 2-year follow-up. We examined whether the relationships between clinical and functional variables were mediated by prolactin, controlling for antipsychotic use, according to sex. Results: Prolactin levels were higher in patients when compared to controls at both time points. Baseline factors associated with prolactin were chlorpromazine equivalents, attention, and executive functioning. In the FEP group, prolactin levels were associated with functioning and diminished expression in males, and with working memory in females. Prolactin levels (p=0.0134) played a role as a mediator between negative symptomatology (p=0.086) and functional outcome (p=0.008) only in FEP male patients at baseline. Conclusions: Prolactin plays a role in the functionality and clinical symptomatology of FEP patients. Our results suggest that pharmacological counselling in patients with hyperprolactinemia at baseline and negative symptomatology might improve their functional and clinical outcomes.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/52406
url https://hdl.handle.net/2454/52406
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement///PI08%2F0208
info:eu-repo/grantAgreement/MICINN//PI11%2F00325
info:eu-repo/grantAgreement/MINECO//PI14%2F00612
dc.rights.none.fl_str_mv © 2024 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2024 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/msword
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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