Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up

Background: Catheter-directed therapies (CDT) may be considered for selected patients with pulmonary embolism (PE); (2) Methods: Retrospective observational study including all consecutive patients with acute PE undergoing CDT (mechanical or pharmacomechanical) from January 2010 through December 202...

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Autores: Ribas, Jesús, Valcárcel, Joana, Alba, Esther, Ruíz, Yolanda, Cuartero, Daniel, Iriarte, Adriana, Mora-Luján, José María, Huguet, Marta, Cerdà, Pau, Martínez-Yélamos, Sergio, Corbella Virós, Xavier, Santos, Salud, Riera-Mestre, Antoni
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/2880
Acceso en línea:http://hdl.handle.net/20.500.12328/2880
https://dx.doi.org/10.3390/jcm10204716
Access Level:acceso abierto
Palabra clave:Procediments endovasculars
Mortalitat
Embòlia pulmonar
Trombectomia
Teràpia trombolítica
Filtres de vena cava
Procedimientos endovasculares
Mortalidad
Embolia pulmonar
Trombectomía
Terapia trombolítica
Filtros de vena cava
Endovascular procedures
Mortality
Pulmonary embolism
Thrombectomy
Thrombolytic therapy
Vena cava filters
61
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spelling Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-upRibas, JesúsValcárcel, JoanaAlba, EstherRuíz, YolandaCuartero, DanielIriarte, AdrianaMora-Luján, José MaríaHuguet, MartaCerdà, PauMartínez-Yélamos, SergioCorbella Virós, XavierSantos, SaludRiera-Mestre, AntoniProcediments endovascularsMortalitatEmbòlia pulmonarTrombectomiaTeràpia trombolíticaFiltres de vena cavaProcedimientos endovascularesMortalidadEmbolia pulmonarTrombectomíaTerapia trombolíticaFiltros de vena cavaEndovascular proceduresMortalityPulmonary embolismThrombectomyThrombolytic therapyVena cava filters61Background: Catheter-directed therapies (CDT) may be considered for selected patients with pulmonary embolism (PE); (2) Methods: Retrospective observational study including all consecutive patients with acute PE undergoing CDT (mechanical or pharmacomechanical) from January 2010 through December 2020. The aim was to evaluate in-hospital and long-term mortality and its predictive factors; (3) Results: We included 63 patients, 43 (68.3%) with high-risk PE. All patients underwent mechanical CDT and, additionally, 27 (43%) underwent catheter-directed thrombolysis. Twelve (19%) patients received failed systemic thrombolysis (ST) prior to CDT, and an inferior vena cava (IVC) filter was inserted in 28 (44.5%) patients. In-hospital PE-related and all-cause mortality rates were 31.7%; 95% CI 20.6–44.7% and 42.9%; 95% CI 30.5–56%, respectively. In multivariate analysis, age > 70 years and previous ST were strongly associated with PE-related and all-cause mortality, while IVC filter insertion during the CDT was associated with lower mortality rates. After a median follow-up of 40 (12–60) months, 11 more patients died (mortality rate of 60.3%; 95% CI 47.2–72.4%). Long-term survival was significantly higher in patients who received an IVC filter; (4) Conclusions: Age > 70 years and failure of previous ST were associated with mortality in acute PE patients treated with CDT. In-hospital and long-term mortality were lower in patients who received IVC filter insertion.info:eu-repo/semantics/publishedVersionMDPI2021info:eu-repo/semantics/article13http://hdl.handle.net/20.500.12328/2880https://dx.doi.org/10.3390/jcm10204716reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Clinical Medicine10;20This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/28802026-05-29T05:05:01Z
dc.title.none.fl_str_mv Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up
title Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up
spellingShingle Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up
Ribas, Jesús
Procediments endovasculars
Mortalitat
Embòlia pulmonar
Trombectomia
Teràpia trombolítica
Filtres de vena cava
Procedimientos endovasculares
Mortalidad
Embolia pulmonar
Trombectomía
Terapia trombolítica
Filtros de vena cava
Endovascular procedures
Mortality
Pulmonary embolism
Thrombectomy
Thrombolytic therapy
Vena cava filters
61
title_short Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up
title_full Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up
title_fullStr Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up
title_full_unstemmed Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up
title_sort Catheter-directed therapies in patients with pulmonary embolism: predictive factors of in-hospital mortality and long-term follow-up
dc.creator.none.fl_str_mv Ribas, Jesús
Valcárcel, Joana
Alba, Esther
Ruíz, Yolanda
Cuartero, Daniel
Iriarte, Adriana
Mora-Luján, José María
Huguet, Marta
Cerdà, Pau
Martínez-Yélamos, Sergio
Corbella Virós, Xavier
Santos, Salud
Riera-Mestre, Antoni
author Ribas, Jesús
author_facet Ribas, Jesús
Valcárcel, Joana
Alba, Esther
Ruíz, Yolanda
Cuartero, Daniel
Iriarte, Adriana
Mora-Luján, José María
Huguet, Marta
Cerdà, Pau
Martínez-Yélamos, Sergio
Corbella Virós, Xavier
Santos, Salud
Riera-Mestre, Antoni
author_role author
author2 Valcárcel, Joana
Alba, Esther
Ruíz, Yolanda
Cuartero, Daniel
Iriarte, Adriana
Mora-Luján, José María
Huguet, Marta
Cerdà, Pau
Martínez-Yélamos, Sergio
Corbella Virós, Xavier
Santos, Salud
Riera-Mestre, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Procediments endovasculars
Mortalitat
Embòlia pulmonar
Trombectomia
Teràpia trombolítica
Filtres de vena cava
Procedimientos endovasculares
Mortalidad
Embolia pulmonar
Trombectomía
Terapia trombolítica
Filtros de vena cava
Endovascular procedures
Mortality
Pulmonary embolism
Thrombectomy
Thrombolytic therapy
Vena cava filters
61
topic Procediments endovasculars
Mortalitat
Embòlia pulmonar
Trombectomia
Teràpia trombolítica
Filtres de vena cava
Procedimientos endovasculares
Mortalidad
Embolia pulmonar
Trombectomía
Terapia trombolítica
Filtros de vena cava
Endovascular procedures
Mortality
Pulmonary embolism
Thrombectomy
Thrombolytic therapy
Vena cava filters
61
description Background: Catheter-directed therapies (CDT) may be considered for selected patients with pulmonary embolism (PE); (2) Methods: Retrospective observational study including all consecutive patients with acute PE undergoing CDT (mechanical or pharmacomechanical) from January 2010 through December 2020. The aim was to evaluate in-hospital and long-term mortality and its predictive factors; (3) Results: We included 63 patients, 43 (68.3%) with high-risk PE. All patients underwent mechanical CDT and, additionally, 27 (43%) underwent catheter-directed thrombolysis. Twelve (19%) patients received failed systemic thrombolysis (ST) prior to CDT, and an inferior vena cava (IVC) filter was inserted in 28 (44.5%) patients. In-hospital PE-related and all-cause mortality rates were 31.7%; 95% CI 20.6–44.7% and 42.9%; 95% CI 30.5–56%, respectively. In multivariate analysis, age > 70 years and previous ST were strongly associated with PE-related and all-cause mortality, while IVC filter insertion during the CDT was associated with lower mortality rates. After a median follow-up of 40 (12–60) months, 11 more patients died (mortality rate of 60.3%; 95% CI 47.2–72.4%). Long-term survival was significantly higher in patients who received an IVC filter; (4) Conclusions: Age > 70 years and failure of previous ST were associated with mortality in acute PE patients treated with CDT. In-hospital and long-term mortality were lower in patients who received IVC filter insertion.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/2880
https://dx.doi.org/10.3390/jcm10204716
url http://hdl.handle.net/20.500.12328/2880
https://dx.doi.org/10.3390/jcm10204716
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine
10;20
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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