Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children

Diagnosing pneumonia and identifying those requiring antibiotherapy remain challenging. Chest radiographs (CXR) are often used as the reference standard. We aimed to describe clinical characteristics, host-response biomarkers and etiology, and assess their relationship to CXR findings in children wi...

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Autores: Jullien S, Richard-Greenblatt M, Casellas A, Tshering K, Ribó JL, Sharma R, Tshering T, Pradhan D, Dema K, Ngai M, Muñoz-Almagro C, Kain KC, Bassat Q
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p21193
Acesso em linha:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21193
Access Level:acceso abierto
Palavra-chave:pneumonia
children
Bhutan
radiography
inflammatory markers
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spelling Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese ChildrenJullien SRichard-Greenblatt MCasellas ATshering KRibó JLSharma RTshering TPradhan DDema KNgai MMuñoz-Almagro CKain KCBassat QpneumoniachildrenBhutanradiographyinflammatory markersDiagnosing pneumonia and identifying those requiring antibiotherapy remain challenging. Chest radiographs (CXR) are often used as the reference standard. We aimed to describe clinical characteristics, host-response biomarkers and etiology, and assess their relationship to CXR findings in children with pneumonia in Thimphu, Bhutan. Children between 2 and 59 months hospitalized with WHO-defined pneumonia were prospectively enrolled and classified into radiological endpoint and non-endpoint pneumonia. Blood and nasopharyngeal washing were collected for microbiological analyses and plasma levels of 11 host-response biomarkers were measured. Among 149 children with readable CXR, 39 (26.2%) presented with endpoint pneumonia. Identification of respiratory viruses was common, with no significant differences by radiological outcomes. No clinical sign was suggestive of radiological pneumonia, but children with radiological pneumonia presented higher erythrocyte sedimentation rate, C-reactive protein and procalcitonin. Markers of endothelial and immune activation had little accuracy for the reliable identification of radiological pneumonia.SAGE PUBLICATIONS INC2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21193Global Pediatric HealthISSN: 2333794Xreponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p211932026-05-27T12:37:41Z
dc.title.none.fl_str_mv Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children
title Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children
spellingShingle Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children
Jullien S
pneumonia
children
Bhutan
radiography
inflammatory markers
title_short Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children
title_full Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children
title_fullStr Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children
title_full_unstemmed Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children
title_sort Association of Clinical Signs, Host Biomarkers and Etiology With Radiological Pneumonia in Bhutanese Children
dc.creator.none.fl_str_mv Jullien S
Richard-Greenblatt M
Casellas A
Tshering K
Ribó JL
Sharma R
Tshering T
Pradhan D
Dema K
Ngai M
Muñoz-Almagro C
Kain KC
Bassat Q
author Jullien S
author_facet Jullien S
Richard-Greenblatt M
Casellas A
Tshering K
Ribó JL
Sharma R
Tshering T
Pradhan D
Dema K
Ngai M
Muñoz-Almagro C
Kain KC
Bassat Q
author_role author
author2 Richard-Greenblatt M
Casellas A
Tshering K
Ribó JL
Sharma R
Tshering T
Pradhan D
Dema K
Ngai M
Muñoz-Almagro C
Kain KC
Bassat Q
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv pneumonia
children
Bhutan
radiography
inflammatory markers
topic pneumonia
children
Bhutan
radiography
inflammatory markers
description Diagnosing pneumonia and identifying those requiring antibiotherapy remain challenging. Chest radiographs (CXR) are often used as the reference standard. We aimed to describe clinical characteristics, host-response biomarkers and etiology, and assess their relationship to CXR findings in children with pneumonia in Thimphu, Bhutan. Children between 2 and 59 months hospitalized with WHO-defined pneumonia were prospectively enrolled and classified into radiological endpoint and non-endpoint pneumonia. Blood and nasopharyngeal washing were collected for microbiological analyses and plasma levels of 11 host-response biomarkers were measured. Among 149 children with readable CXR, 39 (26.2%) presented with endpoint pneumonia. Identification of respiratory viruses was common, with no significant differences by radiological outcomes. No clinical sign was suggestive of radiological pneumonia, but children with radiological pneumonia presented higher erythrocyte sedimentation rate, C-reactive protein and procalcitonin. Markers of endothelial and immune activation had little accuracy for the reliable identification of radiological pneumonia.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21193
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21193
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS INC
publisher.none.fl_str_mv SAGE PUBLICATIONS INC
dc.source.none.fl_str_mv Global Pediatric Health
ISSN: 2333794X
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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