Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children

Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in t...

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Autores: Comella-del-Barrio, Patricia, Izquierdo-García, José Luis, Gautier, Jacqueline, Coute Doresca, Mariette Jean, Campos Olivas, Ramón, Santiveri, Clara M., Muriel Moreno, Beatriz, Prat, Cristina, Abellana Sangrà, Rosa Mari, Pérez-Porcuna, Tomàs M., Cuevas, Luis E., Ruiz Cabello, Jesús, Dominguez, Jose
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183292
Acceso en línea:https://hdl.handle.net/2445/183292
Access Level:acceso abierto
Palabra clave:Tuberculosi
Diagnòstic
Pediatria
Tuberculosis
Diagnosis
Pediatrics
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spelling Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in childrenComella-del-Barrio, PatriciaIzquierdo-García, José LuisGautier, JacquelineCoute Doresca, Mariette JeanCampos Olivas, RamónSantiveri, Clara M.Muriel Moreno, BeatrizPrat, CristinaAbellana Sangrà, Rosa MariPérez-Porcuna, Tomàs M.Cuevas, Luis E.Ruiz Cabello, JesúsDominguez, JoseTuberculosiDiagnòsticPediatriaTuberculosisDiagnosisPediatricsTuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in the metabolic response of children with different diagnostic certainty of TB. We included 62 children with signs and symptoms of TB and 55 apparently healthy children. Six of the children with presumptive TB had bacteriologically confirmed TB, 52 children with unconfirmed TB, and 4 children with unlikely TB. Urine metabolic fingerprints were identified using high- and low-field proton NMR platforms and assessed with pattern recognition techniques such as principal components analysis and partial least squares discriminant analysis. We observed differences in the metabolic fingerprint of children with bacteriologically confirmed and unconfirmed TB compared to children with unlikely TB (p = 0.041 and p = 0.013, respectively). Moreover, children with unconfirmed TB with X-rays compatible with TB showed differences in the metabolic fingerprint compared to children with non-pathological X-rays (p = 0.009). Differences in the metabolic fingerprint in children with different diagnostic certainty of TB could contribute to a more accurate characterisation of TB in the paediatric population. The use of metabolomics could be useful to improve the prediction of TB progression and diagnosis in children.Nature Publishing Group2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183292Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41598-021-91545-0Scientific Reports, 2021, vol. 11, num. 1, p. 12006https://doi.org/10.1038/s41598-021-91545-0info:eu-repo/grantAgreement/EC/H2020/823854cc-by (c) Comella-del-Barrio, Patricia et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1832922026-05-27T06:46:51Z
dc.title.none.fl_str_mv Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
title Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
spellingShingle Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
Comella-del-Barrio, Patricia
Tuberculosi
Diagnòstic
Pediatria
Tuberculosis
Diagnosis
Pediatrics
title_short Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
title_full Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
title_fullStr Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
title_full_unstemmed Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
title_sort Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
dc.creator.none.fl_str_mv Comella-del-Barrio, Patricia
Izquierdo-García, José Luis
Gautier, Jacqueline
Coute Doresca, Mariette Jean
Campos Olivas, Ramón
Santiveri, Clara M.
Muriel Moreno, Beatriz
Prat, Cristina
Abellana Sangrà, Rosa Mari
Pérez-Porcuna, Tomàs M.
Cuevas, Luis E.
Ruiz Cabello, Jesús
Dominguez, Jose
author Comella-del-Barrio, Patricia
author_facet Comella-del-Barrio, Patricia
Izquierdo-García, José Luis
Gautier, Jacqueline
Coute Doresca, Mariette Jean
Campos Olivas, Ramón
Santiveri, Clara M.
Muriel Moreno, Beatriz
Prat, Cristina
Abellana Sangrà, Rosa Mari
Pérez-Porcuna, Tomàs M.
Cuevas, Luis E.
Ruiz Cabello, Jesús
Dominguez, Jose
author_role author
author2 Izquierdo-García, José Luis
Gautier, Jacqueline
Coute Doresca, Mariette Jean
Campos Olivas, Ramón
Santiveri, Clara M.
Muriel Moreno, Beatriz
Prat, Cristina
Abellana Sangrà, Rosa Mari
Pérez-Porcuna, Tomàs M.
Cuevas, Luis E.
Ruiz Cabello, Jesús
Dominguez, Jose
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tuberculosi
Diagnòstic
Pediatria
Tuberculosis
Diagnosis
Pediatrics
topic Tuberculosi
Diagnòstic
Pediatria
Tuberculosis
Diagnosis
Pediatrics
description Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in the metabolic response of children with different diagnostic certainty of TB. We included 62 children with signs and symptoms of TB and 55 apparently healthy children. Six of the children with presumptive TB had bacteriologically confirmed TB, 52 children with unconfirmed TB, and 4 children with unlikely TB. Urine metabolic fingerprints were identified using high- and low-field proton NMR platforms and assessed with pattern recognition techniques such as principal components analysis and partial least squares discriminant analysis. We observed differences in the metabolic fingerprint of children with bacteriologically confirmed and unconfirmed TB compared to children with unlikely TB (p = 0.041 and p = 0.013, respectively). Moreover, children with unconfirmed TB with X-rays compatible with TB showed differences in the metabolic fingerprint compared to children with non-pathological X-rays (p = 0.009). Differences in the metabolic fingerprint in children with different diagnostic certainty of TB could contribute to a more accurate characterisation of TB in the paediatric population. The use of metabolomics could be useful to improve the prediction of TB progression and diagnosis in children.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183292
url https://hdl.handle.net/2445/183292
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-91545-0
Scientific Reports, 2021, vol. 11, num. 1, p. 12006
https://doi.org/10.1038/s41598-021-91545-0
info:eu-repo/grantAgreement/EC/H2020/823854
dc.rights.none.fl_str_mv cc-by (c) Comella-del-Barrio, Patricia et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Comella-del-Barrio, Patricia et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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