Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial

S'adjunta carta al director publicada al Vol. 99 núm. 7

Detalles Bibliográficos
Autores: Briones, Javier, Novelli, Silvana, García-Marco, José A., Tomás, José F., Bernal, Teresa, Grande, Carlos, Canales Albendea, Miguel Ángel, Torres Martí, Antoni, Moraleda, José María, Panizo, Carlos Manuel, Jarque, Isidro, Palmero, Francisca, Hernández, Miguel, González Barca, Eva, López, Dulce, Caballero, Dolores, GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/124043
Acceso en línea:https://hdl.handle.net/2445/124043
Access Level:acceso abierto
Palabra clave:Cèl·lules mare
Cèl·lules B
Limfomes
Autotrasplantament
Stem cells
B cells
Lymphomas
Autotransplantation
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spelling Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trialBriones, JavierNovelli, SilvanaGarcía-Marco, José A.Tomás, José F.Bernal, TeresaGrande, CarlosCanales Albendea, Miguel ÁngelTorres Martí, AntoniMoraleda, José MaríaPanizo, Carlos ManuelJarque, IsidroPalmero, FranciscaHernández, MiguelGonzález Barca, EvaLópez, DulceCaballero, DoloresGELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea)Cèl·lules mareCèl·lules BLimfomesAutotrasplantamentStem cellsB cellsLymphomasAutotransplantationS'adjunta carta al director publicada al Vol. 99 núm. 7Lymphoma patients with persistent disease undergoing autologous transplantation have a very poor prognosis in the rituximab era. The addition of radioimmunotherapy to the conditioning regimen may improve the outcome for these patients. In a prospective, phase 2 study, we evaluated the safety and efficacy of the addition of 90Y-ibritumomab tiuxetan to the conditioning chemotherapy in patients with refractory diffuse large B-cell lymphoma. Thirty patients with induction failure (primary refractory; n=18) or refractory to salvage immunochemotherapy at relapse (n=12) were included in the study. The median age of the patients was 53 years (range, 25-67). All patients were given 90Y-ibritumomab tiuxetan at a fixed dose of 0.4 mCi/kg (maximum dose 32 mCi) 14 days prior to the preparative chemotherapy regimen. Histological examination showed that 22 patients had de novo diffuse large B-cell lymphoma and eight had transformed diffuse large B-cell lymphoma. All patients had persistent disease at the time of transplantation, with 25 patients considered to be chemorefractory. The median time to neutrophil recovery (>500 white blood cells/μL) was 11 days (range, 9-21), while the median time to platelet recovery (>20,000 platelets/μL) was 13 days (range, 11-35). The overall response rate at day +100 was 70% (95% CI, 53.6-86.4) with 60% (95% CI, 42.5-77.5) of patients obtaining a complete response. After a median follow-up of 31 months for alive patients (range, 16-54), the estimated 3-year overall and progression-free survival rates are 63% (95% CI, 48-82) and 61% (95% CI, 45-80), respectively. We conclude that autologous transplantation with conditioning including 90Y-ibritumomab tiuxetan is safe and results in a very high response rate with promising survival in this group of patients with refractory diffuse large B-cell lymphoma with a very poor prognosis. Study registered at European Union Drug Regulating Authorities Clinical Trials (EudraCT) N. 2007-003198-22.Ferrata Storti Foundation2018201820142018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/124043Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3324/haematol.2014.108308Haematologica, 2014, vol. 99, num. 3, p. 505-510https://doi.org/10.3324/haematol.2014.108308(c) Ferrata Storti Foundation, 2014info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1240432026-05-29T05:05:01Z
dc.title.none.fl_str_mv Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial
title Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial
spellingShingle Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial
Briones, Javier
Cèl·lules mare
Cèl·lules B
Limfomes
Autotrasplantament
Stem cells
B cells
Lymphomas
Autotransplantation
title_short Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial
title_full Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial
title_fullStr Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial
title_full_unstemmed Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial
title_sort Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial
dc.creator.none.fl_str_mv Briones, Javier
Novelli, Silvana
García-Marco, José A.
Tomás, José F.
Bernal, Teresa
Grande, Carlos
Canales Albendea, Miguel Ángel
Torres Martí, Antoni
Moraleda, José María
Panizo, Carlos Manuel
Jarque, Isidro
Palmero, Francisca
Hernández, Miguel
González Barca, Eva
López, Dulce
Caballero, Dolores
GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea)
author Briones, Javier
author_facet Briones, Javier
Novelli, Silvana
García-Marco, José A.
Tomás, José F.
Bernal, Teresa
Grande, Carlos
Canales Albendea, Miguel Ángel
Torres Martí, Antoni
Moraleda, José María
Panizo, Carlos Manuel
Jarque, Isidro
Palmero, Francisca
Hernández, Miguel
González Barca, Eva
López, Dulce
Caballero, Dolores
GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea)
author_role author
author2 Novelli, Silvana
García-Marco, José A.
Tomás, José F.
Bernal, Teresa
Grande, Carlos
Canales Albendea, Miguel Ángel
Torres Martí, Antoni
Moraleda, José María
Panizo, Carlos Manuel
Jarque, Isidro
Palmero, Francisca
Hernández, Miguel
González Barca, Eva
López, Dulce
Caballero, Dolores
GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea)
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cèl·lules mare
Cèl·lules B
Limfomes
Autotrasplantament
Stem cells
B cells
Lymphomas
Autotransplantation
topic Cèl·lules mare
Cèl·lules B
Limfomes
Autotrasplantament
Stem cells
B cells
Lymphomas
Autotransplantation
description S'adjunta carta al director publicada al Vol. 99 núm. 7
publishDate 2014
dc.date.none.fl_str_mv 2014
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124043
url https://hdl.handle.net/2445/124043
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3324/haematol.2014.108308
Haematologica, 2014, vol. 99, num. 3, p. 505-510
https://doi.org/10.3324/haematol.2014.108308
dc.rights.none.fl_str_mv (c) Ferrata Storti Foundation, 2014
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Ferrata Storti Foundation, 2014
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Ferrata Storti Foundation
publisher.none.fl_str_mv Ferrata Storti Foundation
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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