Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity

Peña González, Cornelia Emeritina|||0000-0002-9049-8804; García Broncado, Pilar; Ottaviani, Maria Francesca; Cangiotti, Michela; Fattori, Alberto; Hierro Oliva, Margarita; González Martín, M. Luisa; Pérez Serrano, Jorge|||0000-0002-4870-8978; Gómez Ramírez, Rafael|||0000-0001-6448-2414; Muñoz Fernández, María Ángeles; Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285; Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935

Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity

Anionic carbosilane dendrons decorated with sulfonate functions and with a thiol moiety at the focal point have been used to synthesize water soluble gold nanoparticles (AuNPs) by direct reaction of dendrons, gold precursor and reducing agent in water and also by place-exchange reaction. These nanop...

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Detalles Bibliográficos
Autores:	Peña González, Cornelia Emeritina\|\|\|0000-0002-9049-8804, García Broncado, Pilar, Ottaviani, Maria Francesca, Cangiotti, Michela, Fattori, Alberto, Hierro Oliva, Margarita, González Martín, M. Luisa, Pérez Serrano, Jorge\|\|\|0000-0002-4870-8978, Gómez Ramírez, Rafael\|\|\|0000-0001-6448-2414, Muñoz Fernández, María Ángeles, Sánchez-Nieves Fernández, Javier\|\|\|0000-0003-0410-2285, Mata de la Mata, Francisco Javier de la\|\|\|0000-0003-0418-3935
Tipo de recurso:	artículo
Fecha de publicación:	2016
País:	España
Institución:	Universidad de Alcalá (UAH)
Repositorio:	e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:	inglés
OAI Identifier:	oai:ebuah.uah.es:10017/34039
Acceso en línea:	http://hdl.handle.net/10017/34039 https://dx.doi.org/10.1002 /chem .201504262
Access Level:	acceso abierto
Palabra clave:	Gold nanoparticles Sulfonate carbosilane dendrons Antivirus agents HIV EPR Química Chemistry

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spelling	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral ActivityPeña González, Cornelia Emeritina\|\|\|0000-0002-9049-8804García Broncado, PilarOttaviani, Maria FrancescaCangiotti, MichelaFattori, AlbertoHierro Oliva, MargaritaGonzález Martín, M. LuisaPérez Serrano, Jorge\|\|\|0000-0002-4870-8978Gómez Ramírez, Rafael\|\|\|0000-0001-6448-2414Muñoz Fernández, María ÁngelesSánchez-Nieves Fernández, Javier\|\|\|0000-0003-0410-2285Mata de la Mata, Francisco Javier de la\|\|\|0000-0003-0418-3935Gold nanoparticlesSulfonate carbosilane dendronsAntivirus agentsHIVEPRQuímicaChemistryAnionic carbosilane dendrons decorated with sulfonate functions and with a thiol moiety at the focal point have been used to synthesize water soluble gold nanoparticles (AuNPs) by direct reaction of dendrons, gold precursor and reducing agent in water and also by place-exchange reaction. These nanoparticles have been characterized by nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), UV, elemental analysis, and Z potential. Also, the interacting ability of the anionic sulfonate functions was investigated by electron paramagnetic resonance (EPR) using copper(II) as a probe. It was found that the different structures and conformations of the AuNPs modulate the availability of sulfonate and thiol groups to be complexed by copper(II). Toxicity assays of AuNPs showed that those produced by direct reaction were less toxic than those obtained by ligand exchange. Inhibition of HIV-1 infection was higher for dendronized AuNPs than for dendrons.Ministerio de Economía y EmpresaComunidad de MadridUniversidad de AlcaláWiley20162016-02-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/34039https://dx.doi.org/10.1002 /chem .201504262reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available CTQ2011-23245 DISEÑO DE NANOSISTEMAS DENDRÍTICOS BIFUNCIONALES DE NATURALEZA CARBOSILANO PARA SU APLICACIÓN EN BIOMEDICINAMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available CTQ-2014-54004-P DISEÑO DE SISTEMAS DENDRÍTICOS AVANZADOS PARA SU USO EN BIOMEDICINA, OBTENIDOS A TRAVÉS DE PROCESOS DE DENDRONIZACIÓNComunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available S2011%2FBMD-2351 Nanosistemas Dendríticos para Aplicaciones Biomédicas - Dendritic Nanosystems for Biomedical AplicationsUE Not available PT13%2F0010%2F0028 Plataforma de BiobancosUE Not available PI13%2F02016 Desarrollo y mecanismo de acción de dendrimeros como microbicidas para frenar la infección por el VIH por transmisión sexual (vaginal y anal): Prueba de conceptoopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/340392026-06-18T11:13:07Z
dc.title.none.fl_str_mv	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
title	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
spellingShingle	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity Peña González, Cornelia Emeritina\|\|\|0000-0002-9049-8804 Gold nanoparticles Sulfonate carbosilane dendrons Antivirus agents HIV EPR Química Chemistry
title_short	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
title_full	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
title_fullStr	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
title_full_unstemmed	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
title_sort	Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
dc.creator.none.fl_str_mv	Peña González, Cornelia Emeritina\|\|\|0000-0002-9049-8804 García Broncado, Pilar Ottaviani, Maria Francesca Cangiotti, Michela Fattori, Alberto Hierro Oliva, Margarita González Martín, M. Luisa Pérez Serrano, Jorge\|\|\|0000-0002-4870-8978 Gómez Ramírez, Rafael\|\|\|0000-0001-6448-2414 Muñoz Fernández, María Ángeles Sánchez-Nieves Fernández, Javier\|\|\|0000-0003-0410-2285 Mata de la Mata, Francisco Javier de la\|\|\|0000-0003-0418-3935
author	Peña González, Cornelia Emeritina\|\|\|0000-0002-9049-8804
author_facet	Peña González, Cornelia Emeritina\|\|\|0000-0002-9049-8804 García Broncado, Pilar Ottaviani, Maria Francesca Cangiotti, Michela Fattori, Alberto Hierro Oliva, Margarita González Martín, M. Luisa Pérez Serrano, Jorge\|\|\|0000-0002-4870-8978 Gómez Ramírez, Rafael\|\|\|0000-0001-6448-2414 Muñoz Fernández, María Ángeles Sánchez-Nieves Fernández, Javier\|\|\|0000-0003-0410-2285 Mata de la Mata, Francisco Javier de la\|\|\|0000-0003-0418-3935
author_role	author
author2	García Broncado, Pilar Ottaviani, Maria Francesca Cangiotti, Michela Fattori, Alberto Hierro Oliva, Margarita González Martín, M. Luisa Pérez Serrano, Jorge\|\|\|0000-0002-4870-8978 Gómez Ramírez, Rafael\|\|\|0000-0001-6448-2414 Muñoz Fernández, María Ángeles Sánchez-Nieves Fernández, Javier\|\|\|0000-0003-0410-2285 Mata de la Mata, Francisco Javier de la\|\|\|0000-0003-0418-3935
author2_role	author author author author author author author author author author author
dc.subject.none.fl_str_mv	Gold nanoparticles Sulfonate carbosilane dendrons Antivirus agents HIV EPR Química Chemistry
topic	Gold nanoparticles Sulfonate carbosilane dendrons Antivirus agents HIV EPR Química Chemistry
description	Anionic carbosilane dendrons decorated with sulfonate functions and with a thiol moiety at the focal point have been used to synthesize water soluble gold nanoparticles (AuNPs) by direct reaction of dendrons, gold precursor and reducing agent in water and also by place-exchange reaction. These nanoparticles have been characterized by nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), UV, elemental analysis, and Z potential. Also, the interacting ability of the anionic sulfonate functions was investigated by electron paramagnetic resonance (EPR) using copper(II) as a probe. It was found that the different structures and conformations of the AuNPs modulate the availability of sulfonate and thiol groups to be complexed by copper(II). Toxicity assays of AuNPs showed that those produced by direct reaction were less toxic than those obtained by ligand exchange. Inhibition of HIV-1 infection was higher for dendronized AuNPs than for dendrons.
publishDate	2016
dc.date.none.fl_str_mv	2016 2016-02-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10017/34039 https://dx.doi.org/10.1002 /chem .201504262
url	http://hdl.handle.net/10017/34039 https://dx.doi.org/10.1002 /chem .201504262
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available CTQ2011-23245 DISEÑO DE NANOSISTEMAS DENDRÍTICOS BIFUNCIONALES DE NATURALEZA CARBOSILANO PARA SU APLICACIÓN EN BIOMEDICINA Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available CTQ-2014-54004-P DISEÑO DE SISTEMAS DENDRÍTICOS AVANZADOS PARA SU USO EN BIOMEDICINA, OBTENIDOS A TRAVÉS DE PROCESOS DE DENDRONIZACIÓN Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available S2011%2FBMD-2351 Nanosistemas Dendríticos para Aplicaciones Biomédicas - Dendritic Nanosystems for Biomedical Aplications UE Not available PT13%2F0010%2F0028 Plataforma de Biobancos UE Not available PI13%2F02016 Desarrollo y mecanismo de acción de dendrimeros como microbicidas para frenar la infección por el VIH por transmisión sexual (vaginal y anal): Prueba de concepto
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	reponame:e_Buah Biblioteca Digital Universidad de Alcalá instname:Universidad de Alcalá (UAH)
instname_str	Universidad de Alcalá (UAH)
reponame_str	e_Buah Biblioteca Digital Universidad de Alcalá
collection	e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity

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