Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents

Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the supercationic peptide de...

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Autores: Ramchuran, Estelle J., Pérez Guillén, Isabel, Bester, Linda A., Khan, René, Albericio Palomera, Fernando, Viñas, Miquel, Torre, Beatriz G. de la
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/178991
Acesso em linha:https://hdl.handle.net/2445/178991
Access Level:acceso abierto
Palavra-chave:Síntesi en fase sólida
Pèptids
Antibiòtics
Bacteris gramnegatius
Solid-phase synthesis
Peptides
Antibiotics
Gram-negative bacteria
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spelling Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial AgentsRamchuran, Estelle J.Pérez Guillén, IsabelBester, Linda A.Khan, RenéAlbericio Palomera, FernandoViñas, MiquelTorre, Beatriz G. de laSíntesi en fase sólidaPèptidsAntibiòticsBacteris gramnegatiusSolid-phase synthesisPeptidesAntibioticsGram-negative bacteriaMicrobial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the supercationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria.MDPI2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/178991Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/antibiotics10060695Antibiotics, 2021, vol. 10, num. 6, p. 695https://doi.org/10.3390/antibiotics10060695cc-by (c) Ramchuran, Estelle J. et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1789912026-05-29T05:05:01Z
dc.title.none.fl_str_mv Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
title Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
spellingShingle Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
Ramchuran, Estelle J.
Síntesi en fase sólida
Pèptids
Antibiòtics
Bacteris gramnegatius
Solid-phase synthesis
Peptides
Antibiotics
Gram-negative bacteria
title_short Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
title_full Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
title_fullStr Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
title_full_unstemmed Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
title_sort Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
dc.creator.none.fl_str_mv Ramchuran, Estelle J.
Pérez Guillén, Isabel
Bester, Linda A.
Khan, René
Albericio Palomera, Fernando
Viñas, Miquel
Torre, Beatriz G. de la
author Ramchuran, Estelle J.
author_facet Ramchuran, Estelle J.
Pérez Guillén, Isabel
Bester, Linda A.
Khan, René
Albericio Palomera, Fernando
Viñas, Miquel
Torre, Beatriz G. de la
author_role author
author2 Pérez Guillén, Isabel
Bester, Linda A.
Khan, René
Albericio Palomera, Fernando
Viñas, Miquel
Torre, Beatriz G. de la
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Síntesi en fase sólida
Pèptids
Antibiòtics
Bacteris gramnegatius
Solid-phase synthesis
Peptides
Antibiotics
Gram-negative bacteria
topic Síntesi en fase sólida
Pèptids
Antibiòtics
Bacteris gramnegatius
Solid-phase synthesis
Peptides
Antibiotics
Gram-negative bacteria
description Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the supercationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178991
url https://hdl.handle.net/2445/178991
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antibiotics10060695
Antibiotics, 2021, vol. 10, num. 6, p. 695
https://doi.org/10.3390/antibiotics10060695
dc.rights.none.fl_str_mv cc-by (c) Ramchuran, Estelle J. et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ramchuran, Estelle J. et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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