Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine

Investigation into the reactive oxygen species (ROS) generating abilities of photosensitizers outside of in-vitro/vivo conditions is a crucial element in the wider study of photodynamic therapy (PDT) in clinical settings. Zinc(II) phthalocyanine tetrasulfonic acid (ZnPcTS) is a water-soluble photose...

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Autores: Smith, Shaun M., Abelha, Thais F., Limón, David, Samperi, Mario, Sharma, Bunty, Plaetzer, Kristjan, Dumoulin, Fabienne, Amabilino, David B., Pérez García, Lluïsa
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/341119
Acesso em linha:http://hdl.handle.net/10261/341119
https://api.elsevier.com/content/abstract/scopus_id/85149250578
Access Level:acceso abierto
Palavra-chave:Aggregation
Fluorescence
Hydrogel
Metal phthalocyanine
Singlet oxygen
Supramolecular
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spelling Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanineSmith, Shaun M.Abelha, Thais F.Limón, DavidSamperi, MarioSharma, BuntyPlaetzer, KristjanDumoulin, FabienneAmabilino, David B.Pérez García, LluïsaAggregationFluorescenceHydrogelMetal phthalocyanineSinglet oxygenSupramolecularInvestigation into the reactive oxygen species (ROS) generating abilities of photosensitizers outside of in-vitro/vivo conditions is a crucial element in the wider study of photodynamic therapy (PDT) in clinical settings. Zinc(II) phthalocyanine tetrasulfonic acid (ZnPcTS) is a water-soluble photosensitizer that can generate ROS as singlet oxygen (SO) under irradiation in the red and far-red region of the electromagnetic spectrum. The incorporation of ZnPcTS into nano-fibers of a bis-imidazolium hydrogel was demonstrated and the material was characterized with photophysical, rheological, and microscopy techniques. This supramolecular material containing ZnPcTS (named ZnPcTS_nEqBase@Gels) was found to significantly enhance the SO generation rate with respect to that of ZnPcTS in an aqueous solution. The effect is attributed mainly to reduced aggregation within the gel microenvironment compared with a solution. Furthermore, the preparation of ZnPcTS_nEqBase@Gels was carried out in the presence of varying amounts (0, 1, 2, 3, 4 eq.) of NaOH to improve the dissolution of ZnPcTSby ensuring full deprotonation of the sulfonate. The gel material containing 4 equivalents of NaOH per phthalocyanine was found to have a significantly greater SO-generating ability than the corresponding material containing no base. This phenomenon was shown to be partially a consequence of reduced aggregation as observed in the spectroscopic characterization. The enhancement in SO generation induced by this type of hybrid material makes it an attractive candidate to be used in different applications when efficient SO production is required.Project PID2020-115663GB-C32 was funded by MCIN/AEI. SMS thanks the University of Nottingham through the Beacon of Excellence Propulsion Futures and the EPSRC through the LDMI DTP for funding. We thank AGAUR (Generalitat de Catalunya) for grant 2021 SGR 01085, DBA thanks the Ministerio de Ciencia e Innovacion for funding through project PID2021-123873NB-I00.With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000917-S).Peer reviewedWorld Scientific PublishingMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)University of NottinghamEngineering and Physical Sciences Research Council (UK)Generalitat de CatalunyaMinisterio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/341119https://api.elsevier.com/content/abstract/scopus_id/85149250578reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115663GB-C32info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123873NB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-SJournal of Porphyrins and Phthalocyanineshttp://doi.org/10.1142/S1088424623500128Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3411192026-05-22T06:33:51Z
dc.title.none.fl_str_mv Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
title Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
spellingShingle Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
Smith, Shaun M.
Aggregation
Fluorescence
Hydrogel
Metal phthalocyanine
Singlet oxygen
Supramolecular
title_short Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
title_full Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
title_fullStr Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
title_full_unstemmed Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
title_sort Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
dc.creator.none.fl_str_mv Smith, Shaun M.
Abelha, Thais F.
Limón, David
Samperi, Mario
Sharma, Bunty
Plaetzer, Kristjan
Dumoulin, Fabienne
Amabilino, David B.
Pérez García, Lluïsa
author Smith, Shaun M.
author_facet Smith, Shaun M.
Abelha, Thais F.
Limón, David
Samperi, Mario
Sharma, Bunty
Plaetzer, Kristjan
Dumoulin, Fabienne
Amabilino, David B.
Pérez García, Lluïsa
author_role author
author2 Abelha, Thais F.
Limón, David
Samperi, Mario
Sharma, Bunty
Plaetzer, Kristjan
Dumoulin, Fabienne
Amabilino, David B.
Pérez García, Lluïsa
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
University of Nottingham
Engineering and Physical Sciences Research Council (UK)
Generalitat de Catalunya
Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aggregation
Fluorescence
Hydrogel
Metal phthalocyanine
Singlet oxygen
Supramolecular
topic Aggregation
Fluorescence
Hydrogel
Metal phthalocyanine
Singlet oxygen
Supramolecular
description Investigation into the reactive oxygen species (ROS) generating abilities of photosensitizers outside of in-vitro/vivo conditions is a crucial element in the wider study of photodynamic therapy (PDT) in clinical settings. Zinc(II) phthalocyanine tetrasulfonic acid (ZnPcTS) is a water-soluble photosensitizer that can generate ROS as singlet oxygen (SO) under irradiation in the red and far-red region of the electromagnetic spectrum. The incorporation of ZnPcTS into nano-fibers of a bis-imidazolium hydrogel was demonstrated and the material was characterized with photophysical, rheological, and microscopy techniques. This supramolecular material containing ZnPcTS (named ZnPcTS_nEqBase@Gels) was found to significantly enhance the SO generation rate with respect to that of ZnPcTS in an aqueous solution. The effect is attributed mainly to reduced aggregation within the gel microenvironment compared with a solution. Furthermore, the preparation of ZnPcTS_nEqBase@Gels was carried out in the presence of varying amounts (0, 1, 2, 3, 4 eq.) of NaOH to improve the dissolution of ZnPcTSby ensuring full deprotonation of the sulfonate. The gel material containing 4 equivalents of NaOH per phthalocyanine was found to have a significantly greater SO-generating ability than the corresponding material containing no base. This phenomenon was shown to be partially a consequence of reduced aggregation as observed in the spectroscopic characterization. The enhancement in SO generation induced by this type of hybrid material makes it an attractive candidate to be used in different applications when efficient SO production is required.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/341119
https://api.elsevier.com/content/abstract/scopus_id/85149250578
url http://hdl.handle.net/10261/341119
https://api.elsevier.com/content/abstract/scopus_id/85149250578
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115663GB-C32
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123873NB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-S
Journal of Porphyrins and Phthalocyanines
http://doi.org/10.1142/S1088424623500128
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv World Scientific Publishing
publisher.none.fl_str_mv World Scientific Publishing
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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