Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid

Thiomers (or thiolated polymers) have broken through as avant-garde approaches in anticancer therapy. Their distinguished reactivity and properties, closely linked to their final applications, justify the extensive research conducted on their preparation and use as smart drug-delivery systems (DDSs)...

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Detalhes bibliográficos
Autores: Grosso, Roberto, Paz Báñez, María Violante de
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/128676
Acesso em linha:https://hdl.handle.net/11441/128676
https://doi.org/10.3390/pharmaceutics13060854
Access Level:acceso abierto
Palavra-chave:Anticancer therapy
Chitosan
Disulfide bonds
EPR effect
Glutathione
Hyaluronic acid
Mucoadhesion
Nanoformulations
Nanotechnology
Permeation enhancer
Preactivated
SiRNA
Smart DDS
Taxanes
Thiolated polymers
Thiolation
Thiomers
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spelling Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acidGrosso, RobertoPaz Báñez, María Violante deAnticancer therapyChitosanDisulfide bondsEPR effectGlutathioneHyaluronic acidMucoadhesionNanoformulationsNanotechnologyPermeation enhancerPreactivatedSiRNASmart DDSTaxanesThiolated polymersThiolationThiomersThiomers (or thiolated polymers) have broken through as avant-garde approaches in anticancer therapy. Their distinguished reactivity and properties, closely linked to their final applications, justify the extensive research conducted on their preparation and use as smart drug-delivery systems (DDSs). Multiple studies have demonstrated that thiomer-rich nanoformulations can overcome major drawbacks found when administering diverse active pharmaceutical ingredients (APIs), especially in cancer therapy. This work focuses on providing a complete and concise review of the synthetic tools available to thiolate cationic and anionic polymers, in particular chitosan (CTS) and hyaluronic acid (HA), respectively, drawing attention to the most successful procedures. Their chemical reactivity and most relevant properties regarding their use in anticancer formulations are also discussed. In addition, a variety of NP formation procedures are outlined, as well as their use in cancer therapy, particularly for taxanes and siRNA. It is expected that the current work could clarify the main synthetic strategies available, with their scope and drawbacks, as well as provide some insight into thiomer chemistry. Therefore, this review can inspire new research strategies in the development of efficient formulations for the treatment of cancer.Multidisciplinary Digital Publishing Institute (MDPI)Química Orgánica y Farmacéutica2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/128676https://doi.org/10.3390/pharmaceutics13060854reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésPharmaceutics, 13 (6), 854.https://doi.org/10.3390/pharmaceutics13060854info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1286762026-06-17T12:51:07Z
dc.title.none.fl_str_mv Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid
title Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid
spellingShingle Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid
Grosso, Roberto
Anticancer therapy
Chitosan
Disulfide bonds
EPR effect
Glutathione
Hyaluronic acid
Mucoadhesion
Nanoformulations
Nanotechnology
Permeation enhancer
Preactivated
SiRNA
Smart DDS
Taxanes
Thiolated polymers
Thiolation
Thiomers
title_short Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid
title_full Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid
title_fullStr Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid
title_full_unstemmed Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid
title_sort Thiolated-polymer-based nanoparticles as an avant-garde approach for anticancer therapies—Reviewing thiomers from chitosan and hyaluronic acid
dc.creator.none.fl_str_mv Grosso, Roberto
Paz Báñez, María Violante de
author Grosso, Roberto
author_facet Grosso, Roberto
Paz Báñez, María Violante de
author_role author
author2 Paz Báñez, María Violante de
author2_role author
dc.contributor.none.fl_str_mv Química Orgánica y Farmacéutica
dc.subject.none.fl_str_mv Anticancer therapy
Chitosan
Disulfide bonds
EPR effect
Glutathione
Hyaluronic acid
Mucoadhesion
Nanoformulations
Nanotechnology
Permeation enhancer
Preactivated
SiRNA
Smart DDS
Taxanes
Thiolated polymers
Thiolation
Thiomers
topic Anticancer therapy
Chitosan
Disulfide bonds
EPR effect
Glutathione
Hyaluronic acid
Mucoadhesion
Nanoformulations
Nanotechnology
Permeation enhancer
Preactivated
SiRNA
Smart DDS
Taxanes
Thiolated polymers
Thiolation
Thiomers
description Thiomers (or thiolated polymers) have broken through as avant-garde approaches in anticancer therapy. Their distinguished reactivity and properties, closely linked to their final applications, justify the extensive research conducted on their preparation and use as smart drug-delivery systems (DDSs). Multiple studies have demonstrated that thiomer-rich nanoformulations can overcome major drawbacks found when administering diverse active pharmaceutical ingredients (APIs), especially in cancer therapy. This work focuses on providing a complete and concise review of the synthetic tools available to thiolate cationic and anionic polymers, in particular chitosan (CTS) and hyaluronic acid (HA), respectively, drawing attention to the most successful procedures. Their chemical reactivity and most relevant properties regarding their use in anticancer formulations are also discussed. In addition, a variety of NP formation procedures are outlined, as well as their use in cancer therapy, particularly for taxanes and siRNA. It is expected that the current work could clarify the main synthetic strategies available, with their scope and drawbacks, as well as provide some insight into thiomer chemistry. Therefore, this review can inspire new research strategies in the development of efficient formulations for the treatment of cancer.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/128676
https://doi.org/10.3390/pharmaceutics13060854
url https://hdl.handle.net/11441/128676
https://doi.org/10.3390/pharmaceutics13060854
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Pharmaceutics, 13 (6), 854.
https://doi.org/10.3390/pharmaceutics13060854
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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