Effect of tumor burden and radical surgery on survival difference between upfront, early interval or delayed cytoreductive surgery in ovarian cancer

We sought to evaluate the impact on survival of tumor burden and surgical complexity in relation to the number of cycles of neoadjuvant chemotherapy (NACT) in patients with advanced ovarian cancer (OC) with minimal (CC-1) or no residual disease (CC-0). This retrospective study included patients with...

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Detalles Bibliográficos
Autores: Angeles Fite, Martina Aida|||0000-0003-4401-3084, Cabarrou, Bastien|||0000-0003-1477-6013, Gil-Moreno, Antonio|||0000-0003-1106-5590, Pérez-Benavente, Assumpció|||0000-0003-1872-9003, Spagnolo, Emanuela|||0000-0001-5566-8479, Rychlik, Agnieszka|||0000-0002-8860-8883, Martínez-Gómez, Carlos|||0000-0002-9652-7880, Guyon, Frédéric|||0000-0002-2647-3004, Zapardiel, Ignacio|||0000-0002-9175-7767, Querleu, Denis|||0000-0002-8240-8231, Illac, Claire|||0000-0003-1423-1398, Migliorelli, Federico|||0000-0002-2185-369X, Bétrian, Sarah|||0000-0001-5369-9378, Ferron, Gwénaël|||0000-0002-1003-9916, Hernández Gutierrez, Alicia|||0000-0002-2494-3041, Martinez, Alejandra|||0000-0002-7633-3536
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:283303
Acceso en línea:https://ddd.uab.cat/record/283303
https://dx.doi.org/urn:doi:10.3802/jgo.2021.32.e78
Access Level:acceso abierto
Palabra clave:Ovarian Neoplasms
Fallopian Tube Neoplasms
Peritoneal Neoplasms
Cytoreduction Surgical Procedures
Neoadjuvant Therapy
Tumor Burden
Descripción
Sumario:We sought to evaluate the impact on survival of tumor burden and surgical complexity in relation to the number of cycles of neoadjuvant chemotherapy (NACT) in patients with advanced ovarian cancer (OC) with minimal (CC-1) or no residual disease (CC-0). This retrospective study included patients with International Federation of Gynaecology and Obstetrics IIIC-IV stage OC who underwent debulking surgery at 4 high-volume institutions between January 2008 and December 2015. We assessed the overall survival (OS) of primary debulking surgery (PDS group), early interval debulking surgery after 3-4 cycles of NACT (early IDS group) and delayed debulking surgery after 6 cycles (DDS group) with CC-0 or CC-1 according to peritoneal cancer index (PCI) and Aletti score. Five hundred forty-nine women were included: 175 (31.9%) had PDS, 224 (40.8%) early IDS and 150 (27.3%) DDS. Regardless of Aletti score, median OS after PDS was significantly higher than after early IDS or DDS, but the survival difference was higher in women with an Aletti score <8. Among patients with PCI ≤10, median OS after PDS was significantly higher than after early IDS or DDS. In women with PCI.

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