Natural product-related multitarget-directed ligands for the potential treatment of neurodegenerative diseases
Neurodegenerative diseases are characterized by the loss of neurons in the brain and/or spinal cord and constitute one of the most important health problems worldwide. Although these diseases have different etiologies and clinical manifestations, they share many mechanistic pathways, including: prot...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/11095 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/11095 |
| Access Level: | acceso abierto |
| Palabra clave: | 615.2 616.8 Neurodegenerative diseases health treatment molecular architecture compounds chemistries drugs Enfermedades neurodegenerativas salud tratamiento arquitectura molecular compuestos quimiotecas fármacos Farmacología (Medicina) Neurociencias (Medicina) Farmacología (Farmacia) Farmacopeas Química farmaceútica Salud pública (Farmacia) Tecnología farmaceútica 2490 Neurociencias 3209 Farmacología 3209.06 Farmacopeas 2390 Química Farmacéutica 3212 Salud Pública |
| Sumario: | Neurodegenerative diseases are characterized by the loss of neurons in the brain and/or spinal cord and constitute one of the most important health problems worldwide. Although these diseases have different etiologies and clinical manifestations, they share many mechanistic pathways, including: protein misfolding, neuroinflammation, impaired mitochondrial function, increase in oxidative stress, mitochondrial disfunction, alterations in calcium homeostasis, etc... |
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