Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents

[EN]Human milk oligosaccharides (HMOs) are unique with regard to their diversity, quantity and complexity, particularly in comparison to bovine milk oligosaccharides. HMOs are associated with functional development during early life, mainly related to immunity and intestinal health. Whether HMOs eli...

Descripción completa

Detalles Bibliográficos
Autores: Vázquez, Enrique, Barranco, Alejandro, Ramírez, Maria, Gruart, Agnes, Delgado-García, José M., Martínez-Lara, Esther, Blanco, Santos, Martín Martín, María Jesús, Castanys, Esther, Buck, Rachael, Prieto, Pedro, Rueda, Ricardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/167874
Acceso en línea:http://hdl.handle.net/10366/167874
Access Level:acceso abierto
Palabra clave:Human milk oligosaccharides2′
FucosyllactoseLong
Long-term potentiation
IntelliCage
Synaptic plasticity
3206 Ciencias de la Nutrición
id ES_5bc9d155dbd15f82eca8a8458e05abfc
oai_identifier_str oai:gredos.usal.es:10366/167874
network_acronym_str ES
network_name_str España
repository_id_str
spelling Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodentsVázquez, EnriqueBarranco, AlejandroRamírez, MariaGruart, AgnesDelgado-García, José M.Martínez-Lara, EstherBlanco, SantosMartín Martín, María JesúsCastanys, EstherBuck, RachaelPrieto, PedroRueda, RicardoHuman milk oligosaccharides2′FucosyllactoseLongLong-term potentiationIntelliCageSynaptic plasticity3206 Ciencias de la Nutrición[EN]Human milk oligosaccharides (HMOs) are unique with regard to their diversity, quantity and complexity, particularly in comparison to bovine milk oligosaccharides. HMOs are associated with functional development during early life, mainly related to immunity and intestinal health. Whether HMOs elicit a positive effect on cognitive capabilities of lactating infants remains an open question. This study evaluated the role of the most abundant HMO, 2′-fucosyllactose (2′-FL), in synaptic plasticity and learning capabilities in rodents. Mice and rats were prepared for the chronic recording of field excitatory postsynaptic potentials evoked at the hippocampal CA3–CA1 synapse. Following chronic oral administration of 2′-FL, both species showed improvements in input/output curves and in long-term potentiation (LTP) evoked experimentally in alert behaving animals. This effect on LTP was related to better performance of animals in various types of learning behavioral tests. Mice were tested for spatial learning, working memory and operant conditioning using the IntelliCage system, while rats were submitted to a fixed-ratio schedule in the Skinner box. In both cases, 2′-FL-treated animals performed significantly better than controls. In addition, chronic administration of 2′-FL increased the expression of different molecules involved in the storage of newly acquired memories, such as the postsynaptic density protein 95, phosphorylated calcium/calmodulin-dependent kinase II and brain-derived neurotrophic factor in cortical and subcortical structures. Taken together, the data show that dietary 2′-FL affects cognitive domains and improves learning and memory in rodents.Abbott laboratoriesAbbott Laboratories202520252015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/167874reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1678742026-06-07T06:28:51Z
dc.title.none.fl_str_mv Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
title Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
spellingShingle Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
Vázquez, Enrique
Human milk oligosaccharides2′
FucosyllactoseLong
Long-term potentiation
IntelliCage
Synaptic plasticity
3206 Ciencias de la Nutrición
title_short Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
title_full Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
title_fullStr Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
title_full_unstemmed Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
title_sort Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
dc.creator.none.fl_str_mv Vázquez, Enrique
Barranco, Alejandro
Ramírez, Maria
Gruart, Agnes
Delgado-García, José M.
Martínez-Lara, Esther
Blanco, Santos
Martín Martín, María Jesús
Castanys, Esther
Buck, Rachael
Prieto, Pedro
Rueda, Ricardo
author Vázquez, Enrique
author_facet Vázquez, Enrique
Barranco, Alejandro
Ramírez, Maria
Gruart, Agnes
Delgado-García, José M.
Martínez-Lara, Esther
Blanco, Santos
Martín Martín, María Jesús
Castanys, Esther
Buck, Rachael
Prieto, Pedro
Rueda, Ricardo
author_role author
author2 Barranco, Alejandro
Ramírez, Maria
Gruart, Agnes
Delgado-García, José M.
Martínez-Lara, Esther
Blanco, Santos
Martín Martín, María Jesús
Castanys, Esther
Buck, Rachael
Prieto, Pedro
Rueda, Ricardo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Human milk oligosaccharides2′
FucosyllactoseLong
Long-term potentiation
IntelliCage
Synaptic plasticity
3206 Ciencias de la Nutrición
topic Human milk oligosaccharides2′
FucosyllactoseLong
Long-term potentiation
IntelliCage
Synaptic plasticity
3206 Ciencias de la Nutrición
description [EN]Human milk oligosaccharides (HMOs) are unique with regard to their diversity, quantity and complexity, particularly in comparison to bovine milk oligosaccharides. HMOs are associated with functional development during early life, mainly related to immunity and intestinal health. Whether HMOs elicit a positive effect on cognitive capabilities of lactating infants remains an open question. This study evaluated the role of the most abundant HMO, 2′-fucosyllactose (2′-FL), in synaptic plasticity and learning capabilities in rodents. Mice and rats were prepared for the chronic recording of field excitatory postsynaptic potentials evoked at the hippocampal CA3–CA1 synapse. Following chronic oral administration of 2′-FL, both species showed improvements in input/output curves and in long-term potentiation (LTP) evoked experimentally in alert behaving animals. This effect on LTP was related to better performance of animals in various types of learning behavioral tests. Mice were tested for spatial learning, working memory and operant conditioning using the IntelliCage system, while rats were submitted to a fixed-ratio schedule in the Skinner box. In both cases, 2′-FL-treated animals performed significantly better than controls. In addition, chronic administration of 2′-FL increased the expression of different molecules involved in the storage of newly acquired memories, such as the postsynaptic density protein 95, phosphorylated calcium/calmodulin-dependent kinase II and brain-derived neurotrophic factor in cortical and subcortical structures. Taken together, the data show that dietary 2′-FL affects cognitive domains and improves learning and memory in rodents.
publishDate 2015
dc.date.none.fl_str_mv 2015
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/167874
url http://hdl.handle.net/10366/167874
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408838739820544
score 15,81155

Similares en LA Referencia