Cytotoxicity Evaluation of Chalcones and Flavanones from the Leaves of Corema album (L.) D. Don
first_pageDownload PDFsettingsOrder Article Reprints Open AccessArticle Cytotoxicity Evaluation of Chalcones and Flavanones from the Leaves of Corema album (L.) D. Don by Antonio Canoyra 1ORCID,Nuria Acero 1ORCID,Dolores Muñoz-Mingarro 2ORCID,Antonio J. León-González 3ORCID,José Luis Espartero 4ORCI...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:dnet:idus________::ef065e11f5ae2f7c6b53565aac4316d1 |
| Acceso en línea: | https://hdl.handle.net/11441/186369 https://doi.org/10.3390/biom16040509 |
| Access Level: | acceso abierto |
| Palabra clave: | Corema album Chalcones Flavanones Dohydroxychalcone Pinocembrin Cytotoxicity |
| Sumario: | first_pageDownload PDFsettingsOrder Article Reprints Open AccessArticle Cytotoxicity Evaluation of Chalcones and Flavanones from the Leaves of Corema album (L.) D. Don by Antonio Canoyra 1ORCID,Nuria Acero 1ORCID,Dolores Muñoz-Mingarro 2ORCID,Antonio J. León-González 3ORCID,José Luis Espartero 4ORCID andCarmen Martín-Cordero 3,*ORCID 1 Pharmaceutical and Health Science Department, Pharmacy Faculty, San Pablo-CEU University, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660 Madrid, Spain 2 Chemistry and Biochemistry Department, Pharmacy Faculty, San Pablo-CEU University, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660 Madrid, Spain 3 Department of Pharmacology, Faculty of Pharmacy, University of Seville, C/P. García González, 2, 41012 Seville, Spain 4 Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Seville, 41012 Sevilla, Spain * Author to whom correspondence should be addressed. Biomolecules 2026, 16(4), 509; https://doi.org/10.3390/biom16040509 Submission received: 22 February 2026 / Revised: 15 March 2026 / Accepted: 25 March 2026 / Published: 28 March 2026 (This article belongs to the Special Issue Phytochemicals: Bioactivity in Disease Prevention, Anti-Inflammation, and Animal/Human Health) Downloadkeyboard_arrow_down Browse Figures Review Reports Versions Notes Abstract In a preliminary screening of phytochemical compounds from Andalusian vascular plants, the ethyl acetate extract obtained from the leaves of Corema album (L.) D. Don (Ericaceae) was selected due to its cytotoxic activity. Eight phenolic compounds were isolated from this extract: four chalcones (2′,4′-dihydroxydihydrochalcone, 2′,4′-dihydroxychalcone, 2′,4′-dihydroxy-6′-methoxydihydrochalcone, 2′-methoxy-4′-hydroxydihydrochalcone) and four flavanones (pinocembrin, 6-methylpinocembrin, 6,8-dimethylpinocembrin and 7-O-prenylpinocembrin). Their structures were elucidated using 1H NMR and 13C NMR data, including 2D NMR, as well as mass spectrometry. These compounds were evaluated using the MTT cytotoxicity assay against human colorectal adenocarcinoma (HT-29) and renal adenocarcinoma (ACHN) cell lines. The chalcone 2′,4′-dihydroxychalcone exhibited greater cytotoxicity than the corresponding 2′,4′-dihydroxydihydrochalcone in both cell lines. The IC50 values (µM ± SEM) were 13.31 ± 0.48 and 9.43 ± 0.34 for the chalcone, and 62.23 ± 1.06 and 54.68 ± 1.62 for the dihydrochalcone, respectively. The introduction of methyl groups at positions 6 and 8 of pinocembrin increased cytotoxicity in the ACHN cell line. The IC50 values (µM ± SEM) were 91.28 ± 3.03 for pinocembrin, 64.36 ± 0.53 for 6-methylpinocembrin, and 28.74 ± 0.35 for 6,8-dimethylpinocembrin. These results highlight the leaves of C. album as a promising source of chalcones and flavanones with pharmacological interest. |
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