CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury

11 pages, 7 figures.-- Supplementary material available online at http://jcs.biologists.org/cgi/content/full/121/8/1224/DC1

Detalhes bibliográficos
Autores: Cortés-Canteli, Marta, Luna Medina, Rosario de, Sanz-SanCristóbal, Marina, Álvarez Barrientos, Alberto, Santos, Ángel, Pérez Castillo, Ana
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2008
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/25042
Acesso em linha:http://hdl.handle.net/10261/25042
Access Level:acceso abierto
Palavra-chave:C/EBPβ
Excitotoxicity
Inflammation
Neurodegeneration
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spelling CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injuryCortés-Canteli, MartaLuna Medina, Rosario deSanz-SanCristóbal, MarinaÁlvarez Barrientos, AlbertoSantos, ÁngelPérez Castillo, AnaC/EBPβExcitotoxicityInflammationNeurodegeneration11 pages, 7 figures.-- Supplementary material available online at http://jcs.biologists.org/cgi/content/full/121/8/1224/DC1The CCAAT/enhancer-binding protein beta (C/EBPbeta, also known as CEBPB) was first identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. Although C/EBPbeta was initially implicated in synaptic plasticity, its function in the brain remains largely unknown. We have previously shown that C/EBPbeta regulates the expression of genes involved in inflammatory processes and brain injury. Here, we have demonstrated that the expression of C/EBPbeta is notably increased in the hippocampus in a murine model of excitotoxicity. Mice lacking C/EBPbeta showed a reduced inflammatory response after kainic acid injection, and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus. These data reveal an essential function for C/EBPbeta in the pathways leading to excitotoxicity-mediated damage and suggest that inhibitors of this transcription factor should be evaluated as possible neuroprotective therapeutic agents.This work was supported by the Ministerio de Educacion y Ciencia grants SAF2004-06263-CO2-01 and SAF2007-62811 (to A.P.-C.) and SAF2004-06263-CO2-02 (to A.S.) and the Comunidad de Madrid grant GR/SAL/0033/2004 (to A.P.-C.). M.C.-C. is a post-doctoral fellow of the Consejo Superior de Investigaciones Científicas. R.L.-M is a fellow from the Ministerio de Educación y Ciencia.Peer reviewedCompany of BiologistsMinisterio de Educación y Ciencia (España)Comunidad de MadridConsejo Superior de Investigaciones Científicas (España)201020102008info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersion3762200 bytesapplication/pdfhttp://hdl.handle.net/10261/25042reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1242/jcs.025031info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/250422026-05-22T06:33:51Z
dc.title.none.fl_str_mv CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury
title CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury
spellingShingle CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury
Cortés-Canteli, Marta
C/EBPβ
Excitotoxicity
Inflammation
Neurodegeneration
title_short CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury
title_full CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury
title_fullStr CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury
title_full_unstemmed CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury
title_sort CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury
dc.creator.none.fl_str_mv Cortés-Canteli, Marta
Luna Medina, Rosario de
Sanz-SanCristóbal, Marina
Álvarez Barrientos, Alberto
Santos, Ángel
Pérez Castillo, Ana
author Cortés-Canteli, Marta
author_facet Cortés-Canteli, Marta
Luna Medina, Rosario de
Sanz-SanCristóbal, Marina
Álvarez Barrientos, Alberto
Santos, Ángel
Pérez Castillo, Ana
author_role author
author2 Luna Medina, Rosario de
Sanz-SanCristóbal, Marina
Álvarez Barrientos, Alberto
Santos, Ángel
Pérez Castillo, Ana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Educación y Ciencia (España)
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas (España)
dc.subject.none.fl_str_mv C/EBPβ
Excitotoxicity
Inflammation
Neurodegeneration
topic C/EBPβ
Excitotoxicity
Inflammation
Neurodegeneration
description 11 pages, 7 figures.-- Supplementary material available online at http://jcs.biologists.org/cgi/content/full/121/8/1224/DC1
publishDate 2008
dc.date.none.fl_str_mv 2008
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/25042
url http://hdl.handle.net/10261/25042
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1242/jcs.025031
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3762200 bytes
application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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