Diurnal variation on tear stability and correlation with tear cytokine concentration

Producción Científica

Detalhes bibliográficos
Autores: Arroyo del Arroyo, Cristina, Byambajav, Mungunshur, Fernández Martínez, Itziar, Martin, Eilidh, González García, María Jesús, López Miguel, Alberto, Valencia Nieto, Laura, Hagan, Suzanne, Enriquez De Salamanca Aladro, Amalia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/53423
Acesso em linha:https://doi.org/10.1016/j.clae.2022.101705
https://uvadoc.uva.es/handle/10324/53423
Access Level:acceso abierto
Palavra-chave:Cytokines
Citoquinas
3201.09 Oftalmología
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oai_identifier_str oai:uvadoc.uva.es:10324/53423
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spelling Diurnal variation on tear stability and correlation with tear cytokine concentrationArroyo del Arroyo, CristinaByambajav, MungunshurFernández Martínez, ItziarMartin, EilidhGonzález García, María JesúsLópez Miguel, AlbertoValencia Nieto, LauraHagan, SuzanneEnriquez De Salamanca Aladro, AmaliaCytokinesCitoquinas3201.09 OftalmologíaProducción CientíficaPurpose: To investigate the effect of time of day on tear evaporation rate (TER) and tear break-up time, and its possible relationship with the concentration of inflammatory tear molecules (cytokines) in healthy subjects. Methods: Participants with healthy ocular surfaces attended 3 visits, including the screening visit (V0), the 2nd visit (V1) and the 3rd visit (V2). There were 7-day intervals between visits. Participants with Dry Eye Disease (DED) were excluded by using appropriate clinical tests during V0. Clinical evaluation (TER and Non-Invasive Tear Break-Up Time (NITBUT)) and tear collection were performed during V1 and V2, between 9 and 10AM and 3-4PM. The relative humidity and temperature of the examination room were also measured. The tear fluid concentrations of 15 cytokines were measured by multiplex bead analysis. Results: Seven men and 10 women (mean age ± S.D; 25.1 ± 6.63 years old) participated in the study. There were no differences in neither the TER and NITBUT outcomes, nor humidity and temperature among times or visits. Eleven out of the 15 cytokines measured were detectable in tear fluids in > 50% of the participants. In the tear levels, no significant (p > 0.05) inter- and/or intra-day differences were detected for EGF, fractalkine, IL-1RA, IL-1β and IP-10. However, significant inter-day differences were found in the tear levels of IL-10 (p = 0.027), IFN-γ (p = 0.035) and TNF-α(p = 0.04) and intra-day differences in the tear levels of IL-8/CXCL8 (p = 0.034) and MCP-1 (p = 0.002). A significant correlation between TER and IL1-β, IL-2, and Fractalkine (p = 0.03, p = 0.03 and p = 0.046, respectively) was found at V1. Conclusions: NITBUT and TER values had no significant variability over the course of a day (AM versus PM), or on different days in healthy participants when humidity and temperature were constant. However, some tear molecule levels did show inter- and intra-day variability, having an inconsistent and moderate correlation with TER diurnal variation.Elsevier2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1016/j.clae.2022.101705https://uvadoc.uva.es/handle/10324/53423reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.sciencedirect.com/science/article/pii/S1367048422001436?via%3Dihubinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/534232026-06-13T12:44:47Z
dc.title.none.fl_str_mv Diurnal variation on tear stability and correlation with tear cytokine concentration
title Diurnal variation on tear stability and correlation with tear cytokine concentration
spellingShingle Diurnal variation on tear stability and correlation with tear cytokine concentration
Arroyo del Arroyo, Cristina
Cytokines
Citoquinas
3201.09 Oftalmología
title_short Diurnal variation on tear stability and correlation with tear cytokine concentration
title_full Diurnal variation on tear stability and correlation with tear cytokine concentration
title_fullStr Diurnal variation on tear stability and correlation with tear cytokine concentration
title_full_unstemmed Diurnal variation on tear stability and correlation with tear cytokine concentration
title_sort Diurnal variation on tear stability and correlation with tear cytokine concentration
dc.creator.none.fl_str_mv Arroyo del Arroyo, Cristina
Byambajav, Mungunshur
Fernández Martínez, Itziar
Martin, Eilidh
González García, María Jesús
López Miguel, Alberto
Valencia Nieto, Laura
Hagan, Suzanne
Enriquez De Salamanca Aladro, Amalia
author Arroyo del Arroyo, Cristina
author_facet Arroyo del Arroyo, Cristina
Byambajav, Mungunshur
Fernández Martínez, Itziar
Martin, Eilidh
González García, María Jesús
López Miguel, Alberto
Valencia Nieto, Laura
Hagan, Suzanne
Enriquez De Salamanca Aladro, Amalia
author_role author
author2 Byambajav, Mungunshur
Fernández Martínez, Itziar
Martin, Eilidh
González García, María Jesús
López Miguel, Alberto
Valencia Nieto, Laura
Hagan, Suzanne
Enriquez De Salamanca Aladro, Amalia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cytokines
Citoquinas
3201.09 Oftalmología
topic Cytokines
Citoquinas
3201.09 Oftalmología
description Producción Científica
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.clae.2022.101705
https://uvadoc.uva.es/handle/10324/53423
url https://doi.org/10.1016/j.clae.2022.101705
https://uvadoc.uva.es/handle/10324/53423
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S1367048422001436?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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