Health-related quality of life in long-term colorectal cancer survivors

The aim of our study is to evaluate the relationship between sociodemographic and clinical characteristics of individuals with Colorectal Cancer (CRC), tumour-intrinsic characteristics and treatment received with health-related quality of life (HRQoL). Methods: Cross-sectional analysis of data from...

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Detalles Bibliográficos
Autores: Marcos Delgado, Alba, Martín Sánchez, Vicente, Molina Barceló, Ana, Alonso Molero, Jessica, Pérez Gómez, Beatriz, Pollán, Marina, Aragonés, Nuria, Ederra Sanza, María, Fernández Tardón, Guillermo, Binefa, Gemma, Moreno, Victor, Barrios Rodríguez, Rocío, Amiano, Pilar, Huerta, José María, Pastor Teso, Enrique, Alguacil, Juan, Castaño Vinyals, Gemma, Kogevinas, Manolis, Molina de la Torre, Antonio José
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/35805
Acceso en línea:https://hdl.handle.net/10902/35805
Access Level:acceso abierto
Palabra clave:Health-related quality of life (HRQoL)
Colorectal cancer
Cancer survivors
Descripción
Sumario:The aim of our study is to evaluate the relationship between sociodemographic and clinical characteristics of individuals with Colorectal Cancer (CRC), tumour-intrinsic characteristics and treatment received with health-related quality of life (HRQoL). Methods: Cross-sectional analysis of data from 805 survivors from the MCC study was conducted. HRQoL was assessed through a general and specific questionnaire, SF-12 and FCSI (Colorectal Symptom Index). Statistical analyses were performed with linear regression with adjustment for sociodemographic variables, stage at diagnosis and histological grade. Results: Participants had survived a median of 7.9 years from diagnosis (IQR 7.1-8.5 years). Age at diagnosis, sex and area showed a clear association with HRQoL in both physical and mental dimensions of the SF-12 questionnaire. A direct association between CRC recurrence was also found in the PCS-12 and MCS-12 dimensions and radical surgery in the PCS-12. Regarding the scores in FCSI questionnaire, statistically significant differences were observed by sex, age and area, with older women being the most impaired (p < 0.001). Conclusions: Age, sex and area was associated with lower scores of HRQoL among CRC survivors. Knowing the determinants related to HRQoL would allow us to lay the groundwork to develop strategies that help reduce morbidity and mortality, relapses and increase HRQoL.

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