Viroids: Survivors from the RNA World?

Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus that it emerged before DNA and proteins, which eventually assumed these roles and relegated RNA to intermediate functions. If such a scenario--the so-called RNA world--existed, we might hope to find its relic...

ver descrição completa

Detalhes bibliográficos
Autores: Flores, Ricardo, Gago, Selma, Serra, Pedro, Sanjuán, Rafael
Formato: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2014
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/107724
Acesso em linha:http://hdl.handle.net/10261/107724
Access Level:acceso abierto
Palavra-chave:viroid-like
satellite RNAs
hepatitis delta virus
Catalytic RNAs
hammerhead ribozymes
small non-coding RNAs
id ES_5b2d2e270f2c873e015b9835e897b61d
oai_identifier_str oai:digital.csic.es:10261/107724
network_acronym_str ES
network_name_str España
repository_id_str
spelling Viroids: Survivors from the RNA World?Flores, RicardoGago, SelmaSerra, PedroSanjuán, Rafaelviroid-likesatellite RNAshepatitis delta virusCatalytic RNAshammerhead ribozymessmall non-coding RNAsBecause RNA can be a carrier of genetic information and a biocatalyst, there is a consensus that it emerged before DNA and proteins, which eventually assumed these roles and relegated RNA to intermediate functions. If such a scenario--the so-called RNA world--existed, we might hope to find its relics in our present world. The properties of viroids that make them candidates for being survivors of the RNA world include those expected for primitive RNA replicons: (a) small size imposed by error-prone replication, (b) high G + C content to increase replication fidelity, (c) circular structure for assuring complete replication without genomic tags, (d) structural periodicity for modular assembly into enlarged genomes, (e) lack of protein-coding ability consistent with a ribosome-free habitat, and (f) replication mediated in some by ribozymes, the fingerprint of the RNA world. With the advent of DNA and proteins, those protoviroids lost some abilities and became the plant parasites we now know.Peer reviewedElena, Santiago F.Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201420142014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionhttp://hdl.handle.net/10261/107724reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://www.annualreviews.org/doi/pdf/10.1146/annurev-micro-091313-103416Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1077242026-05-22T06:33:51Z
dc.title.none.fl_str_mv Viroids: Survivors from the RNA World?
title Viroids: Survivors from the RNA World?
spellingShingle Viroids: Survivors from the RNA World?
Flores, Ricardo
viroid-like
satellite RNAs
hepatitis delta virus
Catalytic RNAs
hammerhead ribozymes
small non-coding RNAs
title_short Viroids: Survivors from the RNA World?
title_full Viroids: Survivors from the RNA World?
title_fullStr Viroids: Survivors from the RNA World?
title_full_unstemmed Viroids: Survivors from the RNA World?
title_sort Viroids: Survivors from the RNA World?
dc.creator.none.fl_str_mv Flores, Ricardo
Gago, Selma
Serra, Pedro
Sanjuán, Rafael
author Flores, Ricardo
author_facet Flores, Ricardo
Gago, Selma
Serra, Pedro
Sanjuán, Rafael
author_role author
author2 Gago, Selma
Serra, Pedro
Sanjuán, Rafael
author2_role author
author
author
dc.contributor.none.fl_str_mv Elena, Santiago F.
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv viroid-like
satellite RNAs
hepatitis delta virus
Catalytic RNAs
hammerhead ribozymes
small non-coding RNAs
topic viroid-like
satellite RNAs
hepatitis delta virus
Catalytic RNAs
hammerhead ribozymes
small non-coding RNAs
description Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus that it emerged before DNA and proteins, which eventually assumed these roles and relegated RNA to intermediate functions. If such a scenario--the so-called RNA world--existed, we might hope to find its relics in our present world. The properties of viroids that make them candidates for being survivors of the RNA world include those expected for primitive RNA replicons: (a) small size imposed by error-prone replication, (b) high G + C content to increase replication fidelity, (c) circular structure for assuring complete replication without genomic tags, (d) structural periodicity for modular assembly into enlarged genomes, (e) lack of protein-coding ability consistent with a ribosome-free habitat, and (f) replication mediated in some by ribozymes, the fingerprint of the RNA world. With the advent of DNA and proteins, those protoviroids lost some abilities and became the plant parasites we now know.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/107724
url http://hdl.handle.net/10261/107724
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.annualreviews.org/doi/pdf/10.1146/annurev-micro-091313-103416
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408779228938240
score 15,81155

Registos relacionados