Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction

Abstract Purpose Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resol...

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Autores: Cal-Gonzalez, Jacobo, Vaquero, Juan José, López Herraiz, Joaquín, Pérez-Liva, Mailyn, Soto-Montenegro, María Luisa, Peña-Zalbidea, Santiago, Desco, Manuel, Udías Moinelo, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/101143
Acceso en línea:https://hdl.handle.net/20.500.14352/101143
Access Level:acceso abierto
Palabra clave:539.1
53:61
[68Ga]DOTA-labeled radiotracers
Positron range correction
Small animal PET/CT
PET image reconstruction
Física nuclear
2207.13 Isótopos
2406.06 Física Medica
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oai_identifier_str oai:docta.ucm.es:20.500.14352/101143
network_acronym_str ES
network_name_str España
repository_id_str
spelling Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correctionCal-Gonzalez, JacoboVaquero, Juan JoséLópez Herraiz, JoaquínPérez-Liva, MailynSoto-Montenegro, María LuisaPeña-Zalbidea, SantiagoDesco, ManuelUdías Moinelo, José Manuel539.153:61[68Ga]DOTA-labeled radiotracersPositron range correctionSmall animal PET/CTPET image reconstructionFísica nuclear2207.13 Isótopos2406.06 Física MedicaAbstract Purpose Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since generators accessibility has made Ga-68 tracers wide available, the aim of this study is to show how the quantitative results of [68Ga]DOTA-labeled PET/X-ray computed tomography (CT) imaging of neuroendocrine tumors in mice can be improved using positron range correction (PRC). Procedures Eighteen scans in 12 mice were evaluated, with three different models of tumors: PC12, AR42J, and meningiomas. In addition, three different [68Ga]DOTA-labeled radiotracers were used to evaluate the PRC with different tracer distributions: [68Ga]DOTANOC, [68Ga]DOTATOC, and [68Ga]DOTATATE. Two PRC methods were evaluated: a tissue-dependent (TD-PRC) and a tissue-dependent spatially-variant correction (TDSV-PRC). Taking a region in the liver as reference, the tissue-to-liver ratio values for tumor tissue (TLRtumor), lung (TLRlung), and necrotic areas within the tumors (TLRnecrotic) and their respective relative variations (ΔTLR) were evaluated. Results All TLR values in the PRC images were significantly different (p < 0.05) than the ones from non-PRC images. The relative differences of the tumor TLR values, respect to the case with no PRC, were ΔTLRtumor 87 ± 41 % (TD-PRC) and 85 ± 46 % (TDSV-PRC). TLRlung decreased when applying PRC, being this effect more remarkable for the TDSV-PRC method, with relative differences respect to no PRC: ΔTLRlung = − 45 ± 24 (TD-PRC), − 55 ± 18 (TDSV-PRC). TLRnecrotic values also decreased when using PRC, with more noticeable differences for TD-PRC: ΔTLRnecrotic = − 52 ± 6 (TD-PRC), − 48 ± 8 (TDSV-PRC). Conclusion The PRC methods proposed provide a significant quantitative improvement in [68Ga]DOTA-labeled PET/CT imaging of mice with neuroendocrine tumors, hence demonstrating that these techniques could also ameliorate the deleterious effect of the positron range in clinical PET imaging.SpringerUniversidad Complutense de Madrid20182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/101143reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengTC-2015-3772-1 Not available Not availableTEC2014-56600-R Not available Not availableTEC2016-78052-R Not available Not availableFIS PI11 00616TOPUS S2013 MIT-3024open accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1011432026-06-02T12:44:21Z
dc.title.none.fl_str_mv Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction
title Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction
spellingShingle Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction
Cal-Gonzalez, Jacobo
539.1
53:61
[68Ga]DOTA-labeled radiotracers
Positron range correction
Small animal PET/CT
PET image reconstruction
Física nuclear
2207.13 Isótopos
2406.06 Física Medica
title_short Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction
title_full Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction
title_fullStr Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction
title_full_unstemmed Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction
title_sort Improving PET quantification of small animal [68Ga]DOTA-labeled PET/CT studies by using a CT-based positron range correction
dc.creator.none.fl_str_mv Cal-Gonzalez, Jacobo
Vaquero, Juan José
López Herraiz, Joaquín
Pérez-Liva, Mailyn
Soto-Montenegro, María Luisa
Peña-Zalbidea, Santiago
Desco, Manuel
Udías Moinelo, José Manuel
author Cal-Gonzalez, Jacobo
author_facet Cal-Gonzalez, Jacobo
Vaquero, Juan José
López Herraiz, Joaquín
Pérez-Liva, Mailyn
Soto-Montenegro, María Luisa
Peña-Zalbidea, Santiago
Desco, Manuel
Udías Moinelo, José Manuel
author_role author
author2 Vaquero, Juan José
López Herraiz, Joaquín
Pérez-Liva, Mailyn
Soto-Montenegro, María Luisa
Peña-Zalbidea, Santiago
Desco, Manuel
Udías Moinelo, José Manuel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 539.1
53:61
[68Ga]DOTA-labeled radiotracers
Positron range correction
Small animal PET/CT
PET image reconstruction
Física nuclear
2207.13 Isótopos
2406.06 Física Medica
topic 539.1
53:61
[68Ga]DOTA-labeled radiotracers
Positron range correction
Small animal PET/CT
PET image reconstruction
Física nuclear
2207.13 Isótopos
2406.06 Física Medica
description Abstract Purpose Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since generators accessibility has made Ga-68 tracers wide available, the aim of this study is to show how the quantitative results of [68Ga]DOTA-labeled PET/X-ray computed tomography (CT) imaging of neuroendocrine tumors in mice can be improved using positron range correction (PRC). Procedures Eighteen scans in 12 mice were evaluated, with three different models of tumors: PC12, AR42J, and meningiomas. In addition, three different [68Ga]DOTA-labeled radiotracers were used to evaluate the PRC with different tracer distributions: [68Ga]DOTANOC, [68Ga]DOTATOC, and [68Ga]DOTATATE. Two PRC methods were evaluated: a tissue-dependent (TD-PRC) and a tissue-dependent spatially-variant correction (TDSV-PRC). Taking a region in the liver as reference, the tissue-to-liver ratio values for tumor tissue (TLRtumor), lung (TLRlung), and necrotic areas within the tumors (TLRnecrotic) and their respective relative variations (ΔTLR) were evaluated. Results All TLR values in the PRC images were significantly different (p < 0.05) than the ones from non-PRC images. The relative differences of the tumor TLR values, respect to the case with no PRC, were ΔTLRtumor 87 ± 41 % (TD-PRC) and 85 ± 46 % (TDSV-PRC). TLRlung decreased when applying PRC, being this effect more remarkable for the TDSV-PRC method, with relative differences respect to no PRC: ΔTLRlung = − 45 ± 24 (TD-PRC), − 55 ± 18 (TDSV-PRC). TLRnecrotic values also decreased when using PRC, with more noticeable differences for TD-PRC: ΔTLRnecrotic = − 52 ± 6 (TD-PRC), − 48 ± 8 (TDSV-PRC). Conclusion The PRC methods proposed provide a significant quantitative improvement in [68Ga]DOTA-labeled PET/CT imaging of mice with neuroendocrine tumors, hence demonstrating that these techniques could also ameliorate the deleterious effect of the positron range in clinical PET imaging.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/101143
url https://hdl.handle.net/20.500.14352/101143
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv TC-2015-3772-1 Not available Not available
TEC2014-56600-R Not available Not available
TEC2016-78052-R Not available Not available
FIS PI11 00616
TOPUS S2013 MIT-3024
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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