Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)

Sánchez Vioque, Raúl; Santana-Méridas, Omar; Polissiou, Moschos; Vioque, Javier; Astraka, Konstantina; Alaíz Barragán, Manuel; Herraiz-Peñalver, David; Tarantilis, Petros A.; Girón-Calle, Julio

Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)

25 Páginas, 3 Figuras, 3 Tablas

Detalles Bibliográficos
Autores:	Sánchez Vioque, Raúl, Santana-Méridas, Omar, Polissiou, Moschos, Vioque, Javier, Astraka, Konstantina, Alaíz Barragán, Manuel, Herraiz-Peñalver, David, Tarantilis, Petros A., Girón-Calle, Julio
Tipo de recurso:	artículo
Estado:	Versión aceptada para publicación
Fecha de publicación:	2016
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/132826
Acceso en línea:	http://hdl.handle.net/10261/132826
Access Level:	acceso abierto
Palabra clave:	Bioactive compounds By-product Cancer Crocus sativus Health-promoting Iridaceae

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spelling	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)Sánchez Vioque, RaúlSantana-Méridas, OmarPolissiou, MoschosVioque, JavierAstraka, KonstantinaAlaíz Barragán, ManuelHerraiz-Peñalver, DavidTarantilis, Petros A.Girón-Calle, JulioBioactive compoundsBy-productCancerCrocus sativusHealth-promotingIridaceae25 Páginas, 3 Figuras, 3 TablasSaffron is cultivated for production of the saffron spice. Nevertheless, a huge amount of saffron by-products including corms, tepals and leaves with little or no commercial value are generated during the processing of the spice. This biomass contains bioactive compounds whose exploitation can increase the profitability and sustainability of this traditional crop. A significant amount of polyphenols, mainly glycosides of kaempferol, luteolin and quercetin, have been determined in tepals and leaves of saffron. Proliferation of Caco-2 cells was greatly inhibited by the tepal and leaf extracts (ED50 0.42 mg/ml), while the corm extract caused some signs of toxicity and completely abolished proliferation (ED50 0.05 mg/ml). To our knowledge, these are the first data reporting the inhibition of the proliferation of Caco-2 cells by extracts from tepals and leaves of saffron, and polyphenols could be responsible for this effect.This work has been supported by the grant RTA2013-00005-00-00 (INIA, Spain) and is part of a Short Term Scientific Mission (STSM) carried out in the Agricultural University of Athens (AUA) and supported by the grant COST ActionFA1101 (http://www.saffronomics.org). We are grateful to the European Social Fund, Fundación Parque Científico y Tecnológico de Castilla-La Mancha and Junta de Andalucía for additional financing.Peer reviewedElsevierCSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/132826reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp:dx.doi.org/10.1016/j.jff.2016.03.032Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1328262026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)
title	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)
spellingShingle	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2) Sánchez Vioque, Raúl Bioactive compounds By-product Cancer Crocus sativus Health-promoting Iridaceae
title_short	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)
title_full	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)
title_fullStr	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)
title_full_unstemmed	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)
title_sort	Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)
dc.creator.none.fl_str_mv	Sánchez Vioque, Raúl Santana-Méridas, Omar Polissiou, Moschos Vioque, Javier Astraka, Konstantina Alaíz Barragán, Manuel Herraiz-Peñalver, David Tarantilis, Petros A. Girón-Calle, Julio
author	Sánchez Vioque, Raúl
author_facet	Sánchez Vioque, Raúl Santana-Méridas, Omar Polissiou, Moschos Vioque, Javier Astraka, Konstantina Alaíz Barragán, Manuel Herraiz-Peñalver, David Tarantilis, Petros A. Girón-Calle, Julio
author_role	author
author2	Santana-Méridas, Omar Polissiou, Moschos Vioque, Javier Astraka, Konstantina Alaíz Barragán, Manuel Herraiz-Peñalver, David Tarantilis, Petros A. Girón-Calle, Julio
author2_role	author author author author author author author author
dc.contributor.none.fl_str_mv	CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Bioactive compounds By-product Cancer Crocus sativus Health-promoting Iridaceae
topic	Bioactive compounds By-product Cancer Crocus sativus Health-promoting Iridaceae
description	25 Páginas, 3 Figuras, 3 Tablas
publishDate	2016
dc.date.none.fl_str_mv	2016 2016 2016
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Postprint info:eu-repo/semantics/acceptedVersion
format	article
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/132826
url	http://hdl.handle.net/10261/132826
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	http:dx.doi.org/10.1016/j.jff.2016.03.032 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Polyphenol composition and in vitro antiproliferative effect of corm, tepal and leaf from Crocus sativus L. on human colon adenocarcinoma cells (Caco-2)

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