Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis

Purpose: To assess the capacity of methylxanthines (caffeine, theophylline, theobromine and paraxanthine) to inhibit uric acid crystallization, and to evaluate their potential application in the treatment of uric acid nephrolithiasis. Materials and Methods: The ability of methylxathines to inhibit u...

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Authors: Grases, Fèlix, Rodríguez, Adrián, Costa-Bauzà, Antonia
Format: article
Publication Date:2014
Country:España
Institution:Conselleria de Salut i Consum del Govern de les Illes Balears
Repository:Docusalut
Language:English
OAI Identifier:oai:docusalut.com:20.500.13003/11095
Online Access:https://hdl.handle.net/20.500.13003/11095
Access Level:Open access
Keyword:Uric Acid
Nephrolithiasis
Crystallization
Theobromine
Oxalates
Humans
Microscopy, Electron, Scanning
Caffeine
Cafeína
Oxalatos
Humanos
Microscopía Electrónica de Rastreo
Nefrolitiasis
Ácido Úrico
Cristalización
Teobromina
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spelling Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid NephrolithiasisGrases, FèlixRodríguez, AdriánCosta-Bauzà, AntoniaUric AcidNephrolithiasisCrystallizationTheobromineOxalatesHumansMicroscopy, Electron, ScanningCaffeineCafeínaOxalatosHumanosMicroscopía Electrónica de RastreoNefrolitiasisÁcido ÚricoCristalizaciónTeobrominaPurpose: To assess the capacity of methylxanthines (caffeine, theophylline, theobromine and paraxanthine) to inhibit uric acid crystallization, and to evaluate their potential application in the treatment of uric acid nephrolithiasis. Materials and Methods: The ability of methylxathines to inhibit uric acid nucleation was assayed turbidimetrically. Crystal morphology and its modification due to the effect of theobromine were evaluated by scanning electron microscopy (SEM). The ability of theobromine to inhibit uric acid crystal growth on calculi fragments resulting from extracorporeal shock wave lithotripsy (ESWL) was evaluated using a flow system. Results: The turbidimetric assay showed that among the studied methylxanthines, theobromine could markedly inhibit uric acid nucleation. SEM images showed that the presence of theobromine resulted in thinner uric acid crystals. Furthermore, in a flow system theobromine blocked the regrowth of post-ESWL uric acid calculi fragments. Conclusions: Theobromine, a natural dimethylxanthine present in high amounts in cocoa, acts as an inhibitor of nucleation and crystal growth of uric acid. Therefore, theobromine may be clinically useful in the treatment of uric acid nephrolithiasis.Public Library Science20142014-10-2120142014-10-21research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/11095reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 3.0 Unportedhttps://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/110952026-06-22T12:44:07Z
dc.title.none.fl_str_mv Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis
title Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis
spellingShingle Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis
Grases, Fèlix
Uric Acid
Nephrolithiasis
Crystallization
Theobromine
Oxalates
Humans
Microscopy, Electron, Scanning
Caffeine
Cafeína
Oxalatos
Humanos
Microscopía Electrónica de Rastreo
Nefrolitiasis
Ácido Úrico
Cristalización
Teobromina
title_short Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis
title_full Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis
title_fullStr Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis
title_full_unstemmed Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis
title_sort Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis
dc.creator.none.fl_str_mv Grases, Fèlix
Rodríguez, Adrián
Costa-Bauzà, Antonia
author Grases, Fèlix
author_facet Grases, Fèlix
Rodríguez, Adrián
Costa-Bauzà, Antonia
author_role author
author2 Rodríguez, Adrián
Costa-Bauzà, Antonia
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Uric Acid
Nephrolithiasis
Crystallization
Theobromine
Oxalates
Humans
Microscopy, Electron, Scanning
Caffeine
Cafeína
Oxalatos
Humanos
Microscopía Electrónica de Rastreo
Nefrolitiasis
Ácido Úrico
Cristalización
Teobromina
topic Uric Acid
Nephrolithiasis
Crystallization
Theobromine
Oxalates
Humans
Microscopy, Electron, Scanning
Caffeine
Cafeína
Oxalatos
Humanos
Microscopía Electrónica de Rastreo
Nefrolitiasis
Ácido Úrico
Cristalización
Teobromina
description Purpose: To assess the capacity of methylxanthines (caffeine, theophylline, theobromine and paraxanthine) to inhibit uric acid crystallization, and to evaluate their potential application in the treatment of uric acid nephrolithiasis. Materials and Methods: The ability of methylxathines to inhibit uric acid nucleation was assayed turbidimetrically. Crystal morphology and its modification due to the effect of theobromine were evaluated by scanning electron microscopy (SEM). The ability of theobromine to inhibit uric acid crystal growth on calculi fragments resulting from extracorporeal shock wave lithotripsy (ESWL) was evaluated using a flow system. Results: The turbidimetric assay showed that among the studied methylxanthines, theobromine could markedly inhibit uric acid nucleation. SEM images showed that the presence of theobromine resulted in thinner uric acid crystals. Furthermore, in a flow system theobromine blocked the regrowth of post-ESWL uric acid calculi fragments. Conclusions: Theobromine, a natural dimethylxanthine present in high amounts in cocoa, acts as an inhibitor of nucleation and crystal growth of uric acid. Therefore, theobromine may be clinically useful in the treatment of uric acid nephrolithiasis.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-10-21
2014
2014-10-21
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/11095
url https://hdl.handle.net/20.500.13003/11095
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 3.0 Unported
https://creativecommons.org/licenses/by/3.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 3.0 Unported
https://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library Science
publisher.none.fl_str_mv Public Library Science
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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