Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects

The ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the nucleus accumbens may signi...

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Autores: Heinze, Hans-Jochen, Heldmann, Marcus, Voges, Jurgen, Hinrichs, Hermann, Marco Pallarés, Josep, Hopf, Jens-Max, Müller, Ulf J., Galazky, Imke, Sturm, Volker, Bogerts, Bernard, Münte, Thomas F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/65285
Acceso en línea:https://hdl.handle.net/2445/65285
Access Level:acceso abierto
Palabra clave:Alcoholisme
Estimulació del cervell
Electrofisiologia
Alcoholism
Brain stimulation
Electrophysiology
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spelling Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspectsHeinze, Hans-JochenHeldmann, MarcusVoges, JurgenHinrichs, HermannMarco Pallarés, JosepHopf, Jens-MaxMüller, Ulf J.Galazky, ImkeSturm, VolkerBogerts, BernardMünte, Thomas F.AlcoholismeEstimulació del cervellElectrofisiologiaAlcoholismBrain stimulationElectrophysiologyThe ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the nucleus accumbens may significantly reduce craving in alcohol-dependent patients. Here we report on preliminary clinical and neurophysiological evidence in three male patients who were treated with high frequency deep brain stimulation of the nucleus accumbens bilaterally. All three had been alcohol dependent for many years, unable to abstain from drinking, and had experienced repeated relapses prior to the stimulation. After the operation, craving was greatly reduced and all three patients were able to abstain from drinking for extended periods of time. Immediately after the operation but prior to connection of the stimulation electrodes to the stimulator, local field potentials were obtained from the externalized cables in two patients while they performed cognitive tasks addressing action monitoring and incentive salience of drug related cues. LFPs in the action monitoring task provided further evidence for a role of the nucleus accumbens in goal-directed behaviors. Importantly, alcohol related cue stimuli in the incentive salience task modulated LFPs even though these cues were presented outside of the attentional focus. This implies that cue-related craving involves the nucleus accumbens and is highly automatic.Frontiers Media2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/65285Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.3389/neuro.09.022.2009Frontiers in Human Neuroscience, 2009, vol. 3, p. 1-11http://dx.doi.org/10.3389/neuro.09.022.2009cc-by (c) Heinze, H.J. et al., 2009http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/652852026-05-27T06:46:51Z
dc.title.none.fl_str_mv Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
title Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
spellingShingle Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
Heinze, Hans-Jochen
Alcoholisme
Estimulació del cervell
Electrofisiologia
Alcoholism
Brain stimulation
Electrophysiology
title_short Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
title_full Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
title_fullStr Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
title_full_unstemmed Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
title_sort Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
dc.creator.none.fl_str_mv Heinze, Hans-Jochen
Heldmann, Marcus
Voges, Jurgen
Hinrichs, Hermann
Marco Pallarés, Josep
Hopf, Jens-Max
Müller, Ulf J.
Galazky, Imke
Sturm, Volker
Bogerts, Bernard
Münte, Thomas F.
author Heinze, Hans-Jochen
author_facet Heinze, Hans-Jochen
Heldmann, Marcus
Voges, Jurgen
Hinrichs, Hermann
Marco Pallarés, Josep
Hopf, Jens-Max
Müller, Ulf J.
Galazky, Imke
Sturm, Volker
Bogerts, Bernard
Münte, Thomas F.
author_role author
author2 Heldmann, Marcus
Voges, Jurgen
Hinrichs, Hermann
Marco Pallarés, Josep
Hopf, Jens-Max
Müller, Ulf J.
Galazky, Imke
Sturm, Volker
Bogerts, Bernard
Münte, Thomas F.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alcoholisme
Estimulació del cervell
Electrofisiologia
Alcoholism
Brain stimulation
Electrophysiology
topic Alcoholisme
Estimulació del cervell
Electrofisiologia
Alcoholism
Brain stimulation
Electrophysiology
description The ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the nucleus accumbens may significantly reduce craving in alcohol-dependent patients. Here we report on preliminary clinical and neurophysiological evidence in three male patients who were treated with high frequency deep brain stimulation of the nucleus accumbens bilaterally. All three had been alcohol dependent for many years, unable to abstain from drinking, and had experienced repeated relapses prior to the stimulation. After the operation, craving was greatly reduced and all three patients were able to abstain from drinking for extended periods of time. Immediately after the operation but prior to connection of the stimulation electrodes to the stimulator, local field potentials were obtained from the externalized cables in two patients while they performed cognitive tasks addressing action monitoring and incentive salience of drug related cues. LFPs in the action monitoring task provided further evidence for a role of the nucleus accumbens in goal-directed behaviors. Importantly, alcohol related cue stimuli in the incentive salience task modulated LFPs even though these cues were presented outside of the attentional focus. This implies that cue-related craving involves the nucleus accumbens and is highly automatic.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/65285
url https://hdl.handle.net/2445/65285
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.3389/neuro.09.022.2009
Frontiers in Human Neuroscience, 2009, vol. 3, p. 1-11
http://dx.doi.org/10.3389/neuro.09.022.2009
dc.rights.none.fl_str_mv cc-by (c) Heinze, H.J. et al., 2009
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Heinze, H.J. et al., 2009
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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