Cannabinoid-Based Ocular Therapies and Formulations

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Bibliographic Details
Authors: Saraiva, Sofia M., Martín-Banderas, Lucía, Durán-Lobato, Matilde
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/349808
Online Access:http://hdl.handle.net/10261/349808
Access Level:Open access
Keyword:Cannabinoids
Ocular
Eye
Drug delivery system
Nanoparticles
id ES_5aba4cd3f2237706c46c59247d4fa13d
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spelling Cannabinoid-Based Ocular Therapies and FormulationsSaraiva, Sofia M.Martín-Banderas, LucíaDurán-Lobato, MatildeCannabinoidsOcularEyeDrug delivery systemNanoparticles© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The interest in the pharmacological applications of cannabinoids is largely increasing in a wide range of medical areas. Recently, research on its potential role in eye conditions, many of which are chronic and/or disabling and in need of new alternative treatments, has intensified. However, due to cannabinoids’ unfavorable physicochemical properties and adverse systemic effects, along with ocular biological barriers to local drug administration, drug delivery systems are needed. Hence, this review focused on the following: (i) identifying eye disease conditions potentially subject to treatment with cannabinoids and their pharmacological role, with emphasis on glaucoma, uveitis, diabetic retinopathy, keratitis and the prevention of Pseudomonas aeruginosa infections; (ii) reviewing the physicochemical properties of formulations that must be controlled and/or optimized for successful ocular administration; (iii) analyzing works evaluating cannabinoid-based formulations for ocular administration, with emphasis on results and limitations; and (iv) identifying alternative cannabinoid-based formulations that could potentially be useful for ocular administration strategies. Finally, an overview of the current advances and limitations in the field, the technological challenges to overcome and the prospective further developments, is provided.This research was funded by the Programa Operacional Regional do Centro (CENTRO-04-3559-FSE-000162) within the European Social Fund (ESF).Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/349808reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/pharmaceutics15041077Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3498082026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cannabinoid-Based Ocular Therapies and Formulations
title Cannabinoid-Based Ocular Therapies and Formulations
spellingShingle Cannabinoid-Based Ocular Therapies and Formulations
Saraiva, Sofia M.
Cannabinoids
Ocular
Eye
Drug delivery system
Nanoparticles
title_short Cannabinoid-Based Ocular Therapies and Formulations
title_full Cannabinoid-Based Ocular Therapies and Formulations
title_fullStr Cannabinoid-Based Ocular Therapies and Formulations
title_full_unstemmed Cannabinoid-Based Ocular Therapies and Formulations
title_sort Cannabinoid-Based Ocular Therapies and Formulations
dc.creator.none.fl_str_mv Saraiva, Sofia M.
Martín-Banderas, Lucía
Durán-Lobato, Matilde
author Saraiva, Sofia M.
author_facet Saraiva, Sofia M.
Martín-Banderas, Lucía
Durán-Lobato, Matilde
author_role author
author2 Martín-Banderas, Lucía
Durán-Lobato, Matilde
author2_role author
author
dc.contributor.none.fl_str_mv European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cannabinoids
Ocular
Eye
Drug delivery system
Nanoparticles
topic Cannabinoids
Ocular
Eye
Drug delivery system
Nanoparticles
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/349808
url http://hdl.handle.net/10261/349808
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/pharmaceutics15041077
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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