Kindlin-2 controls bidirectional signaling of integrins.

Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found tha...

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Detalles Bibliográficos
Autores: Montañez, Eloi, Ussar, Siegfried, Schifferer, Martina, Bösl, Michael, Zent, Roy, Moser, Markus, Fässler, Reinhard
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/159963
Acceso en línea:https://hdl.handle.net/2445/159963
Access Level:acceso abierto
Palabra clave:Proteïnes citosquelètiques
Integrines
Metabolisme
Cytoskeletal proteins
Integrins
Metabolism
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spelling Kindlin-2 controls bidirectional signaling of integrins.Montañez, EloiUssar, SiegfriedSchifferer, MartinaBösl, MichaelZent, RoyMoser, MarkusFässler, ReinhardProteïnes citosquelètiquesIntegrinesMetabolismeCytoskeletal proteinsIntegrinsMetabolismControl of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation. Furthermore, we demonstrate that Kindlin-2 is required for integrin outside-in signaling to enable firm adhesion and spreading. Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling.Cold Spring Harbor Laboratory Press2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/159963Articles publicats en revistes (Ciències Fisiològiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1101/gad.469408Genes & Development, 2008, vol. 22, num. 10, p. 1325-1330https://doi.org/10.1101/gad.469408(c) Montañez, Eloi et al., 2008info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1599632026-05-27T06:46:51Z
dc.title.none.fl_str_mv Kindlin-2 controls bidirectional signaling of integrins.
title Kindlin-2 controls bidirectional signaling of integrins.
spellingShingle Kindlin-2 controls bidirectional signaling of integrins.
Montañez, Eloi
Proteïnes citosquelètiques
Integrines
Metabolisme
Cytoskeletal proteins
Integrins
Metabolism
title_short Kindlin-2 controls bidirectional signaling of integrins.
title_full Kindlin-2 controls bidirectional signaling of integrins.
title_fullStr Kindlin-2 controls bidirectional signaling of integrins.
title_full_unstemmed Kindlin-2 controls bidirectional signaling of integrins.
title_sort Kindlin-2 controls bidirectional signaling of integrins.
dc.creator.none.fl_str_mv Montañez, Eloi
Ussar, Siegfried
Schifferer, Martina
Bösl, Michael
Zent, Roy
Moser, Markus
Fässler, Reinhard
author Montañez, Eloi
author_facet Montañez, Eloi
Ussar, Siegfried
Schifferer, Martina
Bösl, Michael
Zent, Roy
Moser, Markus
Fässler, Reinhard
author_role author
author2 Ussar, Siegfried
Schifferer, Martina
Bösl, Michael
Zent, Roy
Moser, Markus
Fässler, Reinhard
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Proteïnes citosquelètiques
Integrines
Metabolisme
Cytoskeletal proteins
Integrins
Metabolism
topic Proteïnes citosquelètiques
Integrines
Metabolisme
Cytoskeletal proteins
Integrins
Metabolism
description Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation. Furthermore, we demonstrate that Kindlin-2 is required for integrin outside-in signaling to enable firm adhesion and spreading. Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/159963
url https://hdl.handle.net/2445/159963
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1101/gad.469408
Genes & Development, 2008, vol. 22, num. 10, p. 1325-1330
https://doi.org/10.1101/gad.469408
dc.rights.none.fl_str_mv (c) Montañez, Eloi et al., 2008
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Montañez, Eloi et al., 2008
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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