Cellular innate immunity against PRRSV and swine influenza viruses

Porcine respiratory disease complex (PRDC) is a polymicrobial syndrome that results from a combination of infectious agents, such as environmental stressors, population size, management strategies, age, and genetics. PRDC results in reduced performance as well as increased mortality rates and produc...

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Detalles Bibliográficos
Autores: Crisci, Elisa, Fraile Sauce, Lorenzo José, Montoya, Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/68297
Acceso en línea:https://doi.org/10.3390/vetsci6010026
http://hdl.handle.net/10459.1/68297
Access Level:acceso abierto
Palabra clave:Pig
Innate immunity
PRRSV
Swine influenza virus
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spelling Cellular innate immunity against PRRSV and swine influenza virusesCrisci, ElisaFraile Sauce, Lorenzo JoséMontoya, MariaPigInnate immunityPRRSVSwine influenza virusPorcine respiratory disease complex (PRDC) is a polymicrobial syndrome that results from a combination of infectious agents, such as environmental stressors, population size, management strategies, age, and genetics. PRDC results in reduced performance as well as increased mortality rates and production costs in the pig industry worldwide. This review focuses on the interactions of two enveloped RNA viruses—porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus (SwIV)—as major etiological agents that contribute to PRDC within the porcine cellular innate immunity during infection. The innate immune system of the porcine lung includes alveolar and parenchymal/interstitial macrophages, neutrophils (PMN), conventional dendritic cells (DC) and plasmacytoid DC, natural killer cells, and γδ T cells, thus the in vitro and in vivo interactions between those cells and PRRSV and SwIV are reviewed. Likewise, the few studies regarding PRRSV-SwIV co-infection are illustrated together with the different modulation mechanisms that are induced by the two viruses. Alterations in responses by natural killer (NK), PMN, or γδ T cells have not received much attention within the scientific community as their counterpart antigen-presenting cells and there are numerous gaps in the knowledge regarding the role of those cells in both infections. This review will help in paving the way for future directions in PRRSV and SwIV research and enhancing the understanding of the innate mechanisms that are involved during infection with these viruses.This research was funded by CSIC.MDPI202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/vetsci6010026http://hdl.handle.net/10459.1/68297http://hdl.handle.net/10459.1/68297reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/vetsci6010026Veterinary Sciences, 2019, vol. 6, núm. 1, article number 26, p. 1-26cc-by (c) Crisci, Elisa et al., 2019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/682972026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cellular innate immunity against PRRSV and swine influenza viruses
title Cellular innate immunity against PRRSV and swine influenza viruses
spellingShingle Cellular innate immunity against PRRSV and swine influenza viruses
Crisci, Elisa
Pig
Innate immunity
PRRSV
Swine influenza virus
title_short Cellular innate immunity against PRRSV and swine influenza viruses
title_full Cellular innate immunity against PRRSV and swine influenza viruses
title_fullStr Cellular innate immunity against PRRSV and swine influenza viruses
title_full_unstemmed Cellular innate immunity against PRRSV and swine influenza viruses
title_sort Cellular innate immunity against PRRSV and swine influenza viruses
dc.creator.none.fl_str_mv Crisci, Elisa
Fraile Sauce, Lorenzo José
Montoya, Maria
author Crisci, Elisa
author_facet Crisci, Elisa
Fraile Sauce, Lorenzo José
Montoya, Maria
author_role author
author2 Fraile Sauce, Lorenzo José
Montoya, Maria
author2_role author
author
dc.subject.none.fl_str_mv Pig
Innate immunity
PRRSV
Swine influenza virus
topic Pig
Innate immunity
PRRSV
Swine influenza virus
description Porcine respiratory disease complex (PRDC) is a polymicrobial syndrome that results from a combination of infectious agents, such as environmental stressors, population size, management strategies, age, and genetics. PRDC results in reduced performance as well as increased mortality rates and production costs in the pig industry worldwide. This review focuses on the interactions of two enveloped RNA viruses—porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus (SwIV)—as major etiological agents that contribute to PRDC within the porcine cellular innate immunity during infection. The innate immune system of the porcine lung includes alveolar and parenchymal/interstitial macrophages, neutrophils (PMN), conventional dendritic cells (DC) and plasmacytoid DC, natural killer cells, and γδ T cells, thus the in vitro and in vivo interactions between those cells and PRRSV and SwIV are reviewed. Likewise, the few studies regarding PRRSV-SwIV co-infection are illustrated together with the different modulation mechanisms that are induced by the two viruses. Alterations in responses by natural killer (NK), PMN, or γδ T cells have not received much attention within the scientific community as their counterpart antigen-presenting cells and there are numerous gaps in the knowledge regarding the role of those cells in both infections. This review will help in paving the way for future directions in PRRSV and SwIV research and enhancing the understanding of the innate mechanisms that are involved during infection with these viruses.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/vetsci6010026
http://hdl.handle.net/10459.1/68297
http://hdl.handle.net/10459.1/68297
url https://doi.org/10.3390/vetsci6010026
http://hdl.handle.net/10459.1/68297
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/vetsci6010026
Veterinary Sciences, 2019, vol. 6, núm. 1, article number 26, p. 1-26
dc.rights.none.fl_str_mv cc-by (c) Crisci, Elisa et al., 2019
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Crisci, Elisa et al., 2019
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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