Cortistain is expressed in a distinct subset of cortical interneurons

Cortistatin is a presumptive neuropeptide that shares 11 of its 14 amino acids with somatostatin. In contrast to somatostatin, administration of cortistatin into the rat brain ventricles specifically enhances slow wave sleep, apparently by antagonizing the effects of acetylcholine on cortical excita...

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Autores: Lecea Flores de Lemus, Luis de, Río Fernández, José Antonio del, Alcántara Horrillo, Soledad, Criado, José R., Morales, Marisela, Danielson, Patria E., Henriksen, Steven J., Soriano García, Eduardo, Sutcliffe, J. Gregor
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1997
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/25550
Acceso en línea:https://hdl.handle.net/2445/25550
Access Level:acceso abierto
Palabra clave:Neuropèptids
Escorça cerebral
Neurones
Neuropeptides
Cerebral cortex
Neurons
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spelling Cortistain is expressed in a distinct subset of cortical interneuronsLecea Flores de Lemus, Luis deRío Fernández, José Antonio delAlcántara Horrillo, SoledadCriado, José R.Morales, MariselaDanielson, Patria E.Henriksen, Steven J.Soriano García, EduardoSutcliffe, J. GregorNeuropèptidsEscorça cerebralNeuronesNeuropeptidesCerebral cortexNeuronsCortistatin is a presumptive neuropeptide that shares 11 of its 14 amino acids with somatostatin. In contrast to somatostatin, administration of cortistatin into the rat brain ventricles specifically enhances slow wave sleep, apparently by antagonizing the effects of acetylcholine on cortical excitability. Here we show that preprocortistatin mRNA is expressed in a subset of GABAergic cells in the cortex and hippocampus that partially overlap with those containing somatostatin. A significant percentage of cortistatin-positive neurons is also positive for parvalbumin. In contrast, no colocalization was found between cortistatin and calretinin, cholecystokinin, or vasoactive intestinal peptide. During development there is a transient increase in cortistatin-expressing cells in the second postnatal week in all cortical areas and in the dentate gyrus. A transient expression of preprocortistatin mRNA in the hilar region at P16 is paralleled by electrophysiological changes in dentate granule cells. Together, these observations suggest mechanisms by which cortistatin may regulate cortical activity.Society for Neuroscience1997info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/25550Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://www.jneurosci.org/content/17/15/5868The Journal of Neuroscience, 1997, vol. 17, num. 15, p. 5868-5880(c) Society for Neuroscience, 1997info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/255502026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cortistain is expressed in a distinct subset of cortical interneurons
title Cortistain is expressed in a distinct subset of cortical interneurons
spellingShingle Cortistain is expressed in a distinct subset of cortical interneurons
Lecea Flores de Lemus, Luis de
Neuropèptids
Escorça cerebral
Neurones
Neuropeptides
Cerebral cortex
Neurons
title_short Cortistain is expressed in a distinct subset of cortical interneurons
title_full Cortistain is expressed in a distinct subset of cortical interneurons
title_fullStr Cortistain is expressed in a distinct subset of cortical interneurons
title_full_unstemmed Cortistain is expressed in a distinct subset of cortical interneurons
title_sort Cortistain is expressed in a distinct subset of cortical interneurons
dc.creator.none.fl_str_mv Lecea Flores de Lemus, Luis de
Río Fernández, José Antonio del
Alcántara Horrillo, Soledad
Criado, José R.
Morales, Marisela
Danielson, Patria E.
Henriksen, Steven J.
Soriano García, Eduardo
Sutcliffe, J. Gregor
author Lecea Flores de Lemus, Luis de
author_facet Lecea Flores de Lemus, Luis de
Río Fernández, José Antonio del
Alcántara Horrillo, Soledad
Criado, José R.
Morales, Marisela
Danielson, Patria E.
Henriksen, Steven J.
Soriano García, Eduardo
Sutcliffe, J. Gregor
author_role author
author2 Río Fernández, José Antonio del
Alcántara Horrillo, Soledad
Criado, José R.
Morales, Marisela
Danielson, Patria E.
Henriksen, Steven J.
Soriano García, Eduardo
Sutcliffe, J. Gregor
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuropèptids
Escorça cerebral
Neurones
Neuropeptides
Cerebral cortex
Neurons
topic Neuropèptids
Escorça cerebral
Neurones
Neuropeptides
Cerebral cortex
Neurons
description Cortistatin is a presumptive neuropeptide that shares 11 of its 14 amino acids with somatostatin. In contrast to somatostatin, administration of cortistatin into the rat brain ventricles specifically enhances slow wave sleep, apparently by antagonizing the effects of acetylcholine on cortical excitability. Here we show that preprocortistatin mRNA is expressed in a subset of GABAergic cells in the cortex and hippocampus that partially overlap with those containing somatostatin. A significant percentage of cortistatin-positive neurons is also positive for parvalbumin. In contrast, no colocalization was found between cortistatin and calretinin, cholecystokinin, or vasoactive intestinal peptide. During development there is a transient increase in cortistatin-expressing cells in the second postnatal week in all cortical areas and in the dentate gyrus. A transient expression of preprocortistatin mRNA in the hilar region at P16 is paralleled by electrophysiological changes in dentate granule cells. Together, these observations suggest mechanisms by which cortistatin may regulate cortical activity.
publishDate 1997
dc.date.none.fl_str_mv 1997
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/25550
url https://hdl.handle.net/2445/25550
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://www.jneurosci.org/content/17/15/5868
The Journal of Neuroscience, 1997, vol. 17, num. 15, p. 5868-5880
dc.rights.none.fl_str_mv (c) Society for Neuroscience, 1997
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Society for Neuroscience, 1997
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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