Development of chiral methodologies by Capillary Electrophoresis with ultraviolet and Mass Spectrometry detection for duloxetine analysis in pharmaceutical formulations
Two chiral methodologies were developed by capillary electrophoresis (CE) with UV and mass spectrometry (MS) detection to ensure the quality control of the drug duloxetine, commercialized as a pure enantiomer. Both methods were optimized to achieve a high baseline enantioresolution (Rs > 2) and a...
| Authors: | , , , |
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| Format: | article |
| Publication Date: | 2014 |
| Country: | España |
| Institution: | Universidad de Alcalá (UAH) |
| Repository: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Language: | English |
| OAI Identifier: | oai:ebuah.uah.es:10017/49007 |
| Online Access: | http://hdl.handle.net/10017/49007 https://dx.doi.org/10.1016/j.chroma.2014.07.038 |
| Access Level: | Open access |
| Keyword: | Capillary electrophoresis Duloxetine Enantioseparation Mass spectrometry Partial filling technique Química Chemistry |
| Summary: | Two chiral methodologies were developed by capillary electrophoresis (CE) with UV and mass spectrometry (MS) detection to ensure the quality control of the drug duloxetine, commercialized as a pure enantiomer. Both methods were optimized to achieve a high baseline enantioresolution (Rs > 2) and an acceptable precision (RSD values 0.05). (C) 2014 Elsevier B.V. All rights reserved. |
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