Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs

Food-responsive enteropathy is the most common diagnosis given for dogs with chronic enteropathy, and there are no tests that can replace treatment trials. Furthermore, there is a lack of information on the specific nutritional status of these patients regarding the lipid profile that could relate t...

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Authors: Higueras, Cristina|||0000-0002-0045-098X, Rey, Ana I.|||0000-0003-4403-9225, Escudero, Rosa|||0000-0002-0124-3632, Díaz-Regañón, David|||0000-0002-1722-8568, Rodríguez Franco, Fernando|||0000-0003-0355-2356, García-Sancho, Mercedes|||0000-0002-8299-3389, Agulla, Beatriz|||0000-0003-0136-8264, Sainz Rodríguez, Ángel|||0000-0001-8682-8017
Format: article
Publication Date:2021
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:252178
Online Access:https://ddd.uab.cat/record/252178
https://dx.doi.org/urn:doi:10.3390/ani12010089
Access Level:Open access
Keyword:Short-chain fatty acids
Odd-chain fatty acids
Long-chain fatty acids
Dog
Food-responsible enteropathy
Gut health
id ES_5a6c44db4c6a2bd73d7fb01577684e7f
oai_identifier_str oai:ddd.uab.cat:252178
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs
A Preliminary Study
title Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs
spellingShingle Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs
Higueras, Cristina|||0000-0002-0045-098X
Short-chain fatty acids
Odd-chain fatty acids
Long-chain fatty acids
Dog
Food-responsible enteropathy
Gut health
title_short Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs
title_full Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs
title_fullStr Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs
title_full_unstemmed Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs
title_sort Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs
dc.creator.none.fl_str_mv Higueras, Cristina|||0000-0002-0045-098X
Rey, Ana I.|||0000-0003-4403-9225
Escudero, Rosa|||0000-0002-0124-3632
Díaz-Regañón, David|||0000-0002-1722-8568
Rodríguez Franco, Fernando|||0000-0003-0355-2356
García-Sancho, Mercedes|||0000-0002-8299-3389
Agulla, Beatriz|||0000-0003-0136-8264
Sainz Rodríguez, Ángel|||0000-0001-8682-8017
author Higueras, Cristina|||0000-0002-0045-098X
author_facet Higueras, Cristina|||0000-0002-0045-098X
Rey, Ana I.|||0000-0003-4403-9225
Escudero, Rosa|||0000-0002-0124-3632
Díaz-Regañón, David|||0000-0002-1722-8568
Rodríguez Franco, Fernando|||0000-0003-0355-2356
García-Sancho, Mercedes|||0000-0002-8299-3389
Agulla, Beatriz|||0000-0003-0136-8264
Sainz Rodríguez, Ángel|||0000-0001-8682-8017
author_role author
author2 Rey, Ana I.|||0000-0003-4403-9225
Escudero, Rosa|||0000-0002-0124-3632
Díaz-Regañón, David|||0000-0002-1722-8568
Rodríguez Franco, Fernando|||0000-0003-0355-2356
García-Sancho, Mercedes|||0000-0002-8299-3389
Agulla, Beatriz|||0000-0003-0136-8264
Sainz Rodríguez, Ángel|||0000-0001-8682-8017
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Short-chain fatty acids
Odd-chain fatty acids
Long-chain fatty acids
Dog
Food-responsible enteropathy
Gut health
topic Short-chain fatty acids
Odd-chain fatty acids
Long-chain fatty acids
Dog
Food-responsible enteropathy
Gut health
description Food-responsive enteropathy is the most common diagnosis given for dogs with chronic enteropathy, and there are no tests that can replace treatment trials. Furthermore, there is a lack of information on the specific nutritional status of these patients regarding the lipid profile that could relate them to the state of health/disease. This study evaluated differences in short-chain fatty acids and the total fatty acid profile of faeces and plasma as possible indicators of food-responsive enteropathy (FRE), as well as its relationship with body condition and the chronic enteropathy activity index. Changes in the long-chain fatty acid of plasma, and short-chain, branched and odd-chain fatty acids of faeces were detected in sick dogs, and high correlations were observed between some of these compounds and the existing calculated indices. The aim of this study was to evaluate differences in short-chain fatty acids (SCFAs) and the total fatty acid profile of faeces or plasma as possible indicators of FRE in comparison with healthy dogs. FRE dogs had a lower concentration (p = 0.026) of plasma α-tocopherol as an indicator of the oxidative status of the animal, and lower C20:5n-3 (p = 0.033), C22:5n-3 (p = 0.005), polyunsaturated fatty acids (PUFA) (p = 0.021) and n-6 (p = 0.041) when compared with the control dogs; furthermore, sick dogs had higher proportions of plasma C20:3n-6 (p = 0.0056). The dogs with FRE showed a decrease in the production of faecal levels of SCFAs, mainly propionic acid (C3) (p = 0.0001) and isovaleric acid (iC5) (p = 0.014). FRE dogs also had a lower proportion of C15:0 (p = 0.0003), C16:1n-9 (p = 0.0095), C16:1n-7 (p = 0.0001), C20:5n-3 (p = 0.0034) and monounsaturated fatty acids (p = 0.0315), and tended to have lower n-3 (p = 0.058) and a reduced desaturase activity index in the stool when compared with the control group. However, the dogs with chronic enteropathy tended to have greater C20:4n-6 (p = 0.065) in their faeces as signs of damage at the intestinal level. The faecal parameters were better predictors than plasma. The highest correlations between faecal odd-chain, medium- or long-chain fatty acids and SCFAs were observed for C15:0 that correlated positively with faecal acetic acid (C2) (r = 0.72, p = 0.004), propionic acid (r = 0.95, p = 0.0001), isobutyric acid (iC4) (r = 0.59, p = 0.027) and isovaleric acid (r = 0.64, p = 0.0136), as well as with total SCFAs (r = 0.61, p = 0.02). Conversely, faecal C20:4n-6 showed a high inverse correlation (r = -0.83, p = 0.0002) with C2 and C3 (r = -0.59, p = 0.027). Canine inflammatory bowel disease (IBD) activity (CIBDAI) index correlated negatively mainly with faecal measurements, such as C3 (r = -0.869, p = 0.0005) and C15:0 (r = -0.825, p = 0.0018), followed by C16:1/C16:0 (r = -0.66, p = 0.0374) and iC5 (r = -0.648, p = 0.0310), which would indicate that these fatty acids could be good non-invasive indicators of the chronic inflammatory status, specifically FRE.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/252178
https://dx.doi.org/urn:doi:10.3390/ani12010089
url https://ddd.uab.cat/record/252178
https://dx.doi.org/urn:doi:10.3390/ani12010089
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in DogsA Preliminary StudyHigueras, Cristina|||0000-0002-0045-098XRey, Ana I.|||0000-0003-4403-9225Escudero, Rosa|||0000-0002-0124-3632Díaz-Regañón, David|||0000-0002-1722-8568Rodríguez Franco, Fernando|||0000-0003-0355-2356García-Sancho, Mercedes|||0000-0002-8299-3389Agulla, Beatriz|||0000-0003-0136-8264Sainz Rodríguez, Ángel|||0000-0001-8682-8017Short-chain fatty acidsOdd-chain fatty acidsLong-chain fatty acidsDogFood-responsible enteropathyGut healthFood-responsive enteropathy is the most common diagnosis given for dogs with chronic enteropathy, and there are no tests that can replace treatment trials. Furthermore, there is a lack of information on the specific nutritional status of these patients regarding the lipid profile that could relate them to the state of health/disease. This study evaluated differences in short-chain fatty acids and the total fatty acid profile of faeces and plasma as possible indicators of food-responsive enteropathy (FRE), as well as its relationship with body condition and the chronic enteropathy activity index. Changes in the long-chain fatty acid of plasma, and short-chain, branched and odd-chain fatty acids of faeces were detected in sick dogs, and high correlations were observed between some of these compounds and the existing calculated indices. The aim of this study was to evaluate differences in short-chain fatty acids (SCFAs) and the total fatty acid profile of faeces or plasma as possible indicators of FRE in comparison with healthy dogs. FRE dogs had a lower concentration (p = 0.026) of plasma α-tocopherol as an indicator of the oxidative status of the animal, and lower C20:5n-3 (p = 0.033), C22:5n-3 (p = 0.005), polyunsaturated fatty acids (PUFA) (p = 0.021) and n-6 (p = 0.041) when compared with the control dogs; furthermore, sick dogs had higher proportions of plasma C20:3n-6 (p = 0.0056). The dogs with FRE showed a decrease in the production of faecal levels of SCFAs, mainly propionic acid (C3) (p = 0.0001) and isovaleric acid (iC5) (p = 0.014). FRE dogs also had a lower proportion of C15:0 (p = 0.0003), C16:1n-9 (p = 0.0095), C16:1n-7 (p = 0.0001), C20:5n-3 (p = 0.0034) and monounsaturated fatty acids (p = 0.0315), and tended to have lower n-3 (p = 0.058) and a reduced desaturase activity index in the stool when compared with the control group. However, the dogs with chronic enteropathy tended to have greater C20:4n-6 (p = 0.065) in their faeces as signs of damage at the intestinal level. The faecal parameters were better predictors than plasma. The highest correlations between faecal odd-chain, medium- or long-chain fatty acids and SCFAs were observed for C15:0 that correlated positively with faecal acetic acid (C2) (r = 0.72, p = 0.004), propionic acid (r = 0.95, p = 0.0001), isobutyric acid (iC4) (r = 0.59, p = 0.027) and isovaleric acid (r = 0.64, p = 0.0136), as well as with total SCFAs (r = 0.61, p = 0.02). Conversely, faecal C20:4n-6 showed a high inverse correlation (r = -0.83, p = 0.0002) with C2 and C3 (r = -0.59, p = 0.027). Canine inflammatory bowel disease (IBD) activity (CIBDAI) index correlated negatively mainly with faecal measurements, such as C3 (r = -0.869, p = 0.0005) and C15:0 (r = -0.825, p = 0.0018), followed by C16:1/C16:0 (r = -0.66, p = 0.0374) and iC5 (r = -0.648, p = 0.0310), which would indicate that these fatty acids could be good non-invasive indicators of the chronic inflammatory status, specifically FRE. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/252178https://dx.doi.org/urn:doi:10.3390/ani12010089reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2521782026-06-06T12:50:31Z
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