Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry

Objective: Both hyperkalemia (HK) and Acute Heart Failure (AHF) are associated with increased short-termmortality, and themanagement of eithermay exacerbate the other. As the relationship betweenHK and AHF is poorly described, our purpose was to determine the relationship between HK and short-term o...

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Autores: Rafique, Zubaid, Fortuny, Maria Jose, Kuo, Dick, Szarpak, Lukasz, Llauger, Lluis, Espinosa, Begona, Gil, Victor, Jacob, Javier, Alquezar-Arbe, Aitor, Andueza, Juan Antonio, Garrido, Jose Manuel, Aguirre, Alfons, Fuentes, Marta, Alonso, Hector, Lucas-Imbernon, Francisco Javier, Bibiano, Carlos, Burillo-Putze, Guillermo, Nunez, Julio, Mullens, Wilfried, Lopez-Ayala, Pedro, Mueller, Christian, Llorens, Pere, Peacock, Frank, Miro, Oscar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17444
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/17444
Access Level:acceso abierto
Palabra clave:Acute heart failure
Potassium
Outcome
Mortality
Emergency department
Revisit
Hospitalization
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spelling Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registryRafique, ZubaidFortuny, Maria JoseKuo, DickSzarpak, LukaszLlauger, LluisEspinosa, BegonaGil, VictorJacob, JavierAlquezar-Arbe, AitorAndueza, Juan AntonioGarrido, Jose ManuelAguirre, AlfonsFuentes, MartaAlonso, HectorLucas-Imbernon, Francisco JavierBibiano, CarlosBurillo-Putze, GuillermoNunez, JulioMullens, WilfriedLopez-Ayala, PedroMueller, ChristianLlorens, PerePeacock, FrankMiro, OscarAcute heart failurePotassiumOutcomeMortalityEmergency departmentRevisitHospitalizationObjective: Both hyperkalemia (HK) and Acute Heart Failure (AHF) are associated with increased short-termmortality, and themanagement of eithermay exacerbate the other. As the relationship betweenHK and AHF is poorly described, our purpose was to determine the relationship between HK and short-term outcomes in Emergency Department (ED) AHF. Methods: The EAHFE Registry enrolls all ED AHF patients from 45 Spanish ED and records in-hospital and postdischarge outcomes. Our primary outcome was all-cause in-hospital death, with secondary outcomes of prolonged hospitalization (>7 days) and 7-day post-discharge adverse events (ED revisit, hospitalization, or death). Associations between serum potassium (sK) and outcomes were explored using logistic regression by restricted cubic spline (RCS) curves, with sK =4.0 mEq/L as the reference, adjusting by age, sex, comorbidities, patient baseline status and chronic treatments. Interaction analyses were performed for the primary outcome. Results: Of 13,606 ED AHF patients, the median (IQR) age was 83 (76-88) years, 54% were women, and the median (IQR) sK was 4.5 mEq/L (4.3-4.9) with a range of 4.0-9.9 mEq/L. In-hospital mortality was 7.7%, with prolonged hospitalization in 35.9%, and a 7-day post-discharge adverse event rate of 8.7%. Adjusted in-hospital mortality increased steadily from sK >= 4.8 (OR = 1.35, 95% CI = 1.01-1.80) to sK = 9.9 (8.41, 3.60-19.6). Nondiabetics with elevated sK had higher odds of death, while chronic treatment with mineralocorticoid-receptor antagonists exhibited a mixed effect. Neither prolonged hospitalization nor post-discharge adverse events was associated with sK. Conclusion: In ED AHF, initial sK>4.8mEq/Lwas independently associated with in-hospitalmortality, suggesting that this cohort may benefit from aggressive HK treatment. (c) 2023 Elsevier Inc. All rights reserved.W B SAUNDERS CO-ELSEVIER INC2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17444AMERICAN JOURNAL OF EMERGENCY MEDICINEISSN: 07356757ISSNe: 15328171reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p174442026-06-07T16:35:31Z
dc.title.none.fl_str_mv Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry
title Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry
spellingShingle Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry
Rafique, Zubaid
Acute heart failure
Potassium
Outcome
Mortality
Emergency department
Revisit
Hospitalization
title_short Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry
title_full Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry
title_fullStr Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry
title_full_unstemmed Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry
title_sort Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry
dc.creator.none.fl_str_mv Rafique, Zubaid
Fortuny, Maria Jose
Kuo, Dick
Szarpak, Lukasz
Llauger, Lluis
Espinosa, Begona
Gil, Victor
Jacob, Javier
Alquezar-Arbe, Aitor
Andueza, Juan Antonio
Garrido, Jose Manuel
Aguirre, Alfons
Fuentes, Marta
Alonso, Hector
Lucas-Imbernon, Francisco Javier
Bibiano, Carlos
Burillo-Putze, Guillermo
Nunez, Julio
Mullens, Wilfried
Lopez-Ayala, Pedro
Mueller, Christian
Llorens, Pere
Peacock, Frank
Miro, Oscar
author Rafique, Zubaid
author_facet Rafique, Zubaid
Fortuny, Maria Jose
Kuo, Dick
Szarpak, Lukasz
Llauger, Lluis
Espinosa, Begona
Gil, Victor
Jacob, Javier
Alquezar-Arbe, Aitor
Andueza, Juan Antonio
Garrido, Jose Manuel
Aguirre, Alfons
Fuentes, Marta
Alonso, Hector
Lucas-Imbernon, Francisco Javier
Bibiano, Carlos
Burillo-Putze, Guillermo
Nunez, Julio
Mullens, Wilfried
Lopez-Ayala, Pedro
Mueller, Christian
Llorens, Pere
Peacock, Frank
Miro, Oscar
author_role author
author2 Fortuny, Maria Jose
Kuo, Dick
Szarpak, Lukasz
Llauger, Lluis
Espinosa, Begona
Gil, Victor
Jacob, Javier
Alquezar-Arbe, Aitor
Andueza, Juan Antonio
Garrido, Jose Manuel
Aguirre, Alfons
Fuentes, Marta
Alonso, Hector
Lucas-Imbernon, Francisco Javier
Bibiano, Carlos
Burillo-Putze, Guillermo
Nunez, Julio
Mullens, Wilfried
Lopez-Ayala, Pedro
Mueller, Christian
Llorens, Pere
Peacock, Frank
Miro, Oscar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Acute heart failure
Potassium
Outcome
Mortality
Emergency department
Revisit
Hospitalization
topic Acute heart failure
Potassium
Outcome
Mortality
Emergency department
Revisit
Hospitalization
description Objective: Both hyperkalemia (HK) and Acute Heart Failure (AHF) are associated with increased short-termmortality, and themanagement of eithermay exacerbate the other. As the relationship betweenHK and AHF is poorly described, our purpose was to determine the relationship between HK and short-term outcomes in Emergency Department (ED) AHF. Methods: The EAHFE Registry enrolls all ED AHF patients from 45 Spanish ED and records in-hospital and postdischarge outcomes. Our primary outcome was all-cause in-hospital death, with secondary outcomes of prolonged hospitalization (>7 days) and 7-day post-discharge adverse events (ED revisit, hospitalization, or death). Associations between serum potassium (sK) and outcomes were explored using logistic regression by restricted cubic spline (RCS) curves, with sK =4.0 mEq/L as the reference, adjusting by age, sex, comorbidities, patient baseline status and chronic treatments. Interaction analyses were performed for the primary outcome. Results: Of 13,606 ED AHF patients, the median (IQR) age was 83 (76-88) years, 54% were women, and the median (IQR) sK was 4.5 mEq/L (4.3-4.9) with a range of 4.0-9.9 mEq/L. In-hospital mortality was 7.7%, with prolonged hospitalization in 35.9%, and a 7-day post-discharge adverse event rate of 8.7%. Adjusted in-hospital mortality increased steadily from sK >= 4.8 (OR = 1.35, 95% CI = 1.01-1.80) to sK = 9.9 (8.41, 3.60-19.6). Nondiabetics with elevated sK had higher odds of death, while chronic treatment with mineralocorticoid-receptor antagonists exhibited a mixed effect. Neither prolonged hospitalization nor post-discharge adverse events was associated with sK. Conclusion: In ED AHF, initial sK>4.8mEq/Lwas independently associated with in-hospitalmortality, suggesting that this cohort may benefit from aggressive HK treatment. (c) 2023 Elsevier Inc. All rights reserved.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/17444
url https://incliva.portalinvestigacion.com/publicaciones/17444
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv W B SAUNDERS CO-ELSEVIER INC
publisher.none.fl_str_mv W B SAUNDERS CO-ELSEVIER INC
dc.source.none.fl_str_mv AMERICAN JOURNAL OF EMERGENCY MEDICINE
ISSN: 07356757
ISSNe: 15328171
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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