Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms

The development of biofilms on different surfaces continues to be a major public health problem. The antimicrobial resistance and the difficulty of finding drugs capable of combating these established biofilms generates the urgent need to find compounds that prevent cells from settling and establish...

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Autores: Gómez Casanova, Natalia|||0000-0002-6983-1895, Martín-Serrano Ortiz, Ángela|||0000-0002-2908-8910, Heredero Bermejo, Irene|||0000-0001-6984-1965, Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285, Copa Patiño, José Luis|||0000-0002-2162-3907, Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/59116
Acesso em linha:http://hdl.handle.net/10017/59116
https://dx.doi.org/10.1016/j.ejpb.2023.07.021
Access Level:acceso abierto
Palavra-chave:Antiadhesion
Biofilm
Candida albicans
Carbosilane dendrimer
Pseudomonas aeruginosa
Staphylococcus aureus
Zwitterionic
Química
Chemistry
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spelling Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganismsGómez Casanova, Natalia|||0000-0002-6983-1895Martín-Serrano Ortiz, Ángela|||0000-0002-2908-8910Heredero Bermejo, Irene|||0000-0001-6984-1965Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285Copa Patiño, José Luis|||0000-0002-2162-3907Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935AntiadhesionBiofilmCandida albicansCarbosilane dendrimerPseudomonas aeruginosaStaphylococcus aureusZwitterionicQuímicaChemistryThe development of biofilms on different surfaces continues to be a major public health problem. The antimicrobial resistance and the difficulty of finding drugs capable of combating these established biofilms generates the urgent need to find compounds that prevent cells from settling and establishing of these complex communities of microorganisms. Zwitterionic modification of nanomaterials allows the formation of a hydration layer, and this highly hydrophilic surface provides antifouling properties as well as a good biocompatibility by preventing non-specific interactions. Thus, they are appropriate candidates to prevent microbial adhesion to different surfaces and, in consequence, avoid biofilm formation. For this reason, we have incorporated zwitterionic moieties in multivalent systems, as are carbosilane dendrimers. Characterization of these systems was performed using nuclear magnetic resonance and mass spectrometry. It has been analysed if the new molecules have capacity to inhibit the biofilm formation in Candida albicans, Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that they were more effective against S. aureus, observing a biofilm reduction of 81.5% treating with 32 mg/L of G2SiZWsf dendrimer and by 72.5% using 32 mg/L of the G3SiZWsf dendrimer. Finally, the absence of cytotoxicity was verified by haemolysis and cytotoxicity studies in human cells lines.Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), SpainMinisterio de Economía, Comercio y EmpresaComunidad de Madrid20232023-07-31journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/59116https://dx.doi.org/10.1016/j.ejpb.2023.07.021reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available PID2020112924RB-100OMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available PID2020-113274RA-I00Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available JIN%2F2021–029Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available S2022BMD-7406Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available EPU-INV%2F2020%2F014open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/591162026-06-18T11:13:07Z
dc.title.none.fl_str_mv Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
title Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
spellingShingle Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
Gómez Casanova, Natalia|||0000-0002-6983-1895
Antiadhesion
Biofilm
Candida albicans
Carbosilane dendrimer
Pseudomonas aeruginosa
Staphylococcus aureus
Zwitterionic
Química
Chemistry
title_short Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
title_full Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
title_fullStr Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
title_full_unstemmed Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
title_sort Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
dc.creator.none.fl_str_mv Gómez Casanova, Natalia|||0000-0002-6983-1895
Martín-Serrano Ortiz, Ángela|||0000-0002-2908-8910
Heredero Bermejo, Irene|||0000-0001-6984-1965
Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285
Copa Patiño, José Luis|||0000-0002-2162-3907
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
author Gómez Casanova, Natalia|||0000-0002-6983-1895
author_facet Gómez Casanova, Natalia|||0000-0002-6983-1895
Martín-Serrano Ortiz, Ángela|||0000-0002-2908-8910
Heredero Bermejo, Irene|||0000-0001-6984-1965
Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285
Copa Patiño, José Luis|||0000-0002-2162-3907
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
author_role author
author2 Martín-Serrano Ortiz, Ángela|||0000-0002-2908-8910
Heredero Bermejo, Irene|||0000-0001-6984-1965
Sánchez-Nieves Fernández, Javier|||0000-0003-0410-2285
Copa Patiño, José Luis|||0000-0002-2162-3907
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Antiadhesion
Biofilm
Candida albicans
Carbosilane dendrimer
Pseudomonas aeruginosa
Staphylococcus aureus
Zwitterionic
Química
Chemistry
topic Antiadhesion
Biofilm
Candida albicans
Carbosilane dendrimer
Pseudomonas aeruginosa
Staphylococcus aureus
Zwitterionic
Química
Chemistry
description The development of biofilms on different surfaces continues to be a major public health problem. The antimicrobial resistance and the difficulty of finding drugs capable of combating these established biofilms generates the urgent need to find compounds that prevent cells from settling and establishing of these complex communities of microorganisms. Zwitterionic modification of nanomaterials allows the formation of a hydration layer, and this highly hydrophilic surface provides antifouling properties as well as a good biocompatibility by preventing non-specific interactions. Thus, they are appropriate candidates to prevent microbial adhesion to different surfaces and, in consequence, avoid biofilm formation. For this reason, we have incorporated zwitterionic moieties in multivalent systems, as are carbosilane dendrimers. Characterization of these systems was performed using nuclear magnetic resonance and mass spectrometry. It has been analysed if the new molecules have capacity to inhibit the biofilm formation in Candida albicans, Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that they were more effective against S. aureus, observing a biofilm reduction of 81.5% treating with 32 mg/L of G2SiZWsf dendrimer and by 72.5% using 32 mg/L of the G3SiZWsf dendrimer. Finally, the absence of cytotoxicity was verified by haemolysis and cytotoxicity studies in human cells lines.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-07-31
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/59116
https://dx.doi.org/10.1016/j.ejpb.2023.07.021
url http://hdl.handle.net/10017/59116
https://dx.doi.org/10.1016/j.ejpb.2023.07.021
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available PID2020112924RB-100O
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available PID2020-113274RA-I00
Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available JIN%2F2021–029
Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available S2022BMD-7406
Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available EPU-INV%2F2020%2F014
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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