Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis

Introduction. This study aimed to investigate the efficacy and safety of quantum molecular resonance (QMR) electrotherapy in patients with dry eye disease (DED). Methods. A systematic review with meta-analysis, reporting the effects of QMR electrotherapy in three databases, PubMed, Scopus and Web of...

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Autores: Ballesteros Sánchez, Antonio, Rocha de Lossada, Carlos, Sánchez González, José María, Tedesco, Giovanni Roberto, Borroni, Davide
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/429414
Acceso en línea:https://hdl.handle.net/2117/429414
https://dx.doi.org/10.1007/s40123-025-01133-y
Access Level:acceso abierto
Palabra clave:Rexon-Eye
Quantum molecular resonance electrotherapy
Transcutaneous electrical stimulation
Dry eye disease
Àrees temàtiques de la UPC::Ciències de la visió
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spelling Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysisBallesteros Sánchez, AntonioRocha de Lossada, CarlosSánchez González, José MaríaTedesco, Giovanni RobertoBorroni, DavideRexon-EyeQuantum molecular resonance electrotherapyTranscutaneous electrical stimulationDry eye diseaseÀrees temàtiques de la UPC::Ciències de la visióIntroduction. This study aimed to investigate the efficacy and safety of quantum molecular resonance (QMR) electrotherapy in patients with dry eye disease (DED). Methods. A systematic review with meta-analysis, reporting the effects of QMR electrotherapy in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement with a search period ending on December 24, 2024. Results. Seven studies, including four open-label, non-comparative trials and three randomized controlled studies (RCTs), were included. Although all studies reported significant improvements in most outcome measures after QMR electrotherapy, the meta-analysis indicated that overall efficacy did not significantly favor either group when comparing QMR electrotherapy to controls (SMD 0.40; 95% CI - 0.06 to 0.86; P¿=¿0.09; I2¿=¿85%). However, only the change in DED symptoms was significantly favorable for QMR electrotherapy compared to controls (SMD 0.69; 95% CI 0.30–1.08; P¿=¿0.0005; I2¿=¿28%). In sensitivity analyses, overall efficacy remained non-significant when comparing QMR electrotherapy to placebo QMR electrotherapy (SMD 0.14; 95% CI - 0.24 to 0.52; P¿=¿0.46; I2¿=¿65%). Additionally, changes in DED symptoms, TBUT, ST, and CFS also showed no statistically significant differences between both groups. Regarding safety, most studies reported no AEs, with a satisfactory tolerability profile for QMR electrotherapy. However, a meta-analysis could not be performed. Conclusions. With the current scientific literature available to date, QMR electrotherapy seems to show some evidence of alleviating DED symptoms. However, evidence supporting its efficacy in improving DED signs and safety remains limited. Therefore, further RCTs with robust designs are needed to confirm these findings.Peer ReviewedSpringer20252025-01-0120252025-05-13journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/429414https://dx.doi.org/10.1007/s40123-025-01133-yreponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4294142026-05-27T15:37:01Z
dc.title.none.fl_str_mv Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis
title Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis
spellingShingle Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis
Ballesteros Sánchez, Antonio
Rexon-Eye
Quantum molecular resonance electrotherapy
Transcutaneous electrical stimulation
Dry eye disease
Àrees temàtiques de la UPC::Ciències de la visió
title_short Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis
title_full Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis
title_fullStr Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis
title_full_unstemmed Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis
title_sort Efficacy and safety of quantum molecular resonance electrotherapy in dry eye disease: a systematic review with Meta-analysis
dc.creator.none.fl_str_mv Ballesteros Sánchez, Antonio
Rocha de Lossada, Carlos
Sánchez González, José María
Tedesco, Giovanni Roberto
Borroni, Davide
author Ballesteros Sánchez, Antonio
author_facet Ballesteros Sánchez, Antonio
Rocha de Lossada, Carlos
Sánchez González, José María
Tedesco, Giovanni Roberto
Borroni, Davide
author_role author
author2 Rocha de Lossada, Carlos
Sánchez González, José María
Tedesco, Giovanni Roberto
Borroni, Davide
author2_role author
author
author
author
dc.subject.none.fl_str_mv Rexon-Eye
Quantum molecular resonance electrotherapy
Transcutaneous electrical stimulation
Dry eye disease
Àrees temàtiques de la UPC::Ciències de la visió
topic Rexon-Eye
Quantum molecular resonance electrotherapy
Transcutaneous electrical stimulation
Dry eye disease
Àrees temàtiques de la UPC::Ciències de la visió
description Introduction. This study aimed to investigate the efficacy and safety of quantum molecular resonance (QMR) electrotherapy in patients with dry eye disease (DED). Methods. A systematic review with meta-analysis, reporting the effects of QMR electrotherapy in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement with a search period ending on December 24, 2024. Results. Seven studies, including four open-label, non-comparative trials and three randomized controlled studies (RCTs), were included. Although all studies reported significant improvements in most outcome measures after QMR electrotherapy, the meta-analysis indicated that overall efficacy did not significantly favor either group when comparing QMR electrotherapy to controls (SMD 0.40; 95% CI - 0.06 to 0.86; P¿=¿0.09; I2¿=¿85%). However, only the change in DED symptoms was significantly favorable for QMR electrotherapy compared to controls (SMD 0.69; 95% CI 0.30–1.08; P¿=¿0.0005; I2¿=¿28%). In sensitivity analyses, overall efficacy remained non-significant when comparing QMR electrotherapy to placebo QMR electrotherapy (SMD 0.14; 95% CI - 0.24 to 0.52; P¿=¿0.46; I2¿=¿65%). Additionally, changes in DED symptoms, TBUT, ST, and CFS also showed no statistically significant differences between both groups. Regarding safety, most studies reported no AEs, with a satisfactory tolerability profile for QMR electrotherapy. However, a meta-analysis could not be performed. Conclusions. With the current scientific literature available to date, QMR electrotherapy seems to show some evidence of alleviating DED symptoms. However, evidence supporting its efficacy in improving DED signs and safety remains limited. Therefore, further RCTs with robust designs are needed to confirm these findings.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
2025
2025-05-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/429414
https://dx.doi.org/10.1007/s40123-025-01133-y
url https://hdl.handle.net/2117/429414
https://dx.doi.org/10.1007/s40123-025-01133-y
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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