Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis

Ulcerative colitis (UC) is a recurrent pathology of complex etiology that has been occasionally associated with oral lesions, but the overall composition of the oral microbiome in UC patients and its role in the pathogenesis of the disease are still poorly understood. In this study, the oral microbi...

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Autores: Molinero, N, Taladrid, D, Zorraquin-Pena, I, de Celis, M, Belda, I, Mira, A, Bartolome, B, Moreno-Arribas, MV
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p13547
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/13547
Access Level:acceso abierto
Palabra clave:ulcerative colitis
oral microbiome
dysbiosis
differential abundance
alpha diversity
oral biomarkers
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spelling Ulcerative Colitis Seems to Imply Oral Microbiome DysbiosisMolinero, NTaladrid, DZorraquin-Pena, Ide Celis, MBelda, IMira, ABartolome, BMoreno-Arribas, MVulcerative colitisoral microbiomedysbiosisdifferential abundancealpha diversityoral biomarkersUlcerative colitis (UC) is a recurrent pathology of complex etiology that has been occasionally associated with oral lesions, but the overall composition of the oral microbiome in UC patients and its role in the pathogenesis of the disease are still poorly understood. In this study, the oral microbiome of UC patients and healthy individuals was compared to ascertain the possible changes in the oral microbial communities associated with UC. For this, the salivary microbiota of 10 patients diagnosed with an active phase of UC and 11 healthy controls was analyzed by 16S rRNA gene sequencing (trial ref. ISRCTN39987). Metataxonomic analysis revealed a decrease in the alpha diversity and an imbalance in the relative proportions of some key members of the oral core microbiome in UC patients. Additionally, Staphylococcus members and four differential species or phylotypes were only present in UC patients, not being detected in healthy subjects. This study provides a global snapshot of the existence of oral dysbiosis associated with UC, and the possible presence of potential oral biomarkers.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/13547CURRENT ISSUES IN MOLECULAR BIOLOGYISSN: 14673037ISSNe: 14673045reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p135472026-06-11T12:45:17Z
dc.title.none.fl_str_mv Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
title Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
spellingShingle Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
Molinero, N
ulcerative colitis
oral microbiome
dysbiosis
differential abundance
alpha diversity
oral biomarkers
title_short Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
title_full Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
title_fullStr Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
title_full_unstemmed Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
title_sort Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
dc.creator.none.fl_str_mv Molinero, N
Taladrid, D
Zorraquin-Pena, I
de Celis, M
Belda, I
Mira, A
Bartolome, B
Moreno-Arribas, MV
author Molinero, N
author_facet Molinero, N
Taladrid, D
Zorraquin-Pena, I
de Celis, M
Belda, I
Mira, A
Bartolome, B
Moreno-Arribas, MV
author_role author
author2 Taladrid, D
Zorraquin-Pena, I
de Celis, M
Belda, I
Mira, A
Bartolome, B
Moreno-Arribas, MV
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ulcerative colitis
oral microbiome
dysbiosis
differential abundance
alpha diversity
oral biomarkers
topic ulcerative colitis
oral microbiome
dysbiosis
differential abundance
alpha diversity
oral biomarkers
description Ulcerative colitis (UC) is a recurrent pathology of complex etiology that has been occasionally associated with oral lesions, but the overall composition of the oral microbiome in UC patients and its role in the pathogenesis of the disease are still poorly understood. In this study, the oral microbiome of UC patients and healthy individuals was compared to ascertain the possible changes in the oral microbial communities associated with UC. For this, the salivary microbiota of 10 patients diagnosed with an active phase of UC and 11 healthy controls was analyzed by 16S rRNA gene sequencing (trial ref. ISRCTN39987). Metataxonomic analysis revealed a decrease in the alpha diversity and an imbalance in the relative proportions of some key members of the oral core microbiome in UC patients. Additionally, Staphylococcus members and four differential species or phylotypes were only present in UC patients, not being detected in healthy subjects. This study provides a global snapshot of the existence of oral dysbiosis associated with UC, and the possible presence of potential oral biomarkers.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/13547
url https://fisabio.portalinvestigacion.com/publicaciones/13547
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv CURRENT ISSUES IN MOLECULAR BIOLOGY
ISSN: 14673037
ISSNe: 14673045
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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