The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study

We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmiss...

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Autores: Brotons, Pedro, Jordan, Iolanda, Bassat, Quique, Henares, Desiree, Fernandez de Sevilla, Mariona, Ajanovic, Sara, Redin, Alba, Fumadó, Victoria, Baró, Bàrbara, Claverol, Joana, Varo, Rosauro, Cuadras, Daniel, Hecht, Jochen, Barrabeig, Irene, Garcia-Garcia, Juan Jose, Launes, Cristian, Muñoz-Almagro, Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/49202
Acceso en línea:http://hdl.handle.net/10230/49202
http://dx.doi.org/10.3390/v13081598
Access Level:acceso abierto
Palabra clave:COVID-19 (Malaltia)
Rinovirus
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spelling The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance studyBrotons, PedroJordan, IolandaBassat, QuiqueHenares, DesireeFernandez de Sevilla, MarionaAjanovic, SaraRedin, AlbaFumadó, VictoriaBaró, BàrbaraClaverol, JoanaVaro, RosauroCuadras, DanielHecht, JochenBarrabeig, IreneGarcia-Garcia, Juan JoseLaunes, CristianMuñoz-Almagro, CarmenCOVID-19 (Malaltia)RinovirusWe aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.Funding: This work was supported by the Kids Corona Project, Hospital Sant Joan de Déu, Barcelona,which received donations from Stavros Niarchos Foundation and Banco de Santander. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID)MDPI202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/49202http://dx.doi.org/10.3390/v13081598reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglés© 2021 by Pedro Brotons et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/492022026-05-29T05:05:01Z
dc.title.none.fl_str_mv The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
spellingShingle The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
Brotons, Pedro
COVID-19 (Malaltia)
Rinovirus
title_short The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title_full The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title_fullStr The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title_full_unstemmed The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
title_sort The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study
dc.creator.none.fl_str_mv Brotons, Pedro
Jordan, Iolanda
Bassat, Quique
Henares, Desiree
Fernandez de Sevilla, Mariona
Ajanovic, Sara
Redin, Alba
Fumadó, Victoria
Baró, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig, Irene
Garcia-Garcia, Juan Jose
Launes, Cristian
Muñoz-Almagro, Carmen
author Brotons, Pedro
author_facet Brotons, Pedro
Jordan, Iolanda
Bassat, Quique
Henares, Desiree
Fernandez de Sevilla, Mariona
Ajanovic, Sara
Redin, Alba
Fumadó, Victoria
Baró, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig, Irene
Garcia-Garcia, Juan Jose
Launes, Cristian
Muñoz-Almagro, Carmen
author_role author
author2 Jordan, Iolanda
Bassat, Quique
Henares, Desiree
Fernandez de Sevilla, Mariona
Ajanovic, Sara
Redin, Alba
Fumadó, Victoria
Baró, Bàrbara
Claverol, Joana
Varo, Rosauro
Cuadras, Daniel
Hecht, Jochen
Barrabeig, Irene
Garcia-Garcia, Juan Jose
Launes, Cristian
Muñoz-Almagro, Carmen
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19 (Malaltia)
Rinovirus
topic COVID-19 (Malaltia)
Rinovirus
description We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/49202
http://dx.doi.org/10.3390/v13081598
url http://hdl.handle.net/10230/49202
http://dx.doi.org/10.3390/v13081598
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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