The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance

Background: Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is of interest to identify cognitive and biological markers that will help impro...

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Autores: Hidalgo Figueroa, María, Salazar, Alejandro, Romero López-Alberca, Cristina, MacDowell, Karina S., García Bueno, Borja, Bioque Alcázar, Miquel, Bernardo Vilamitjana, Mercè, Parellada, Mara, González-Pinto, Ana, García Portilla, María Paz, Lobo, Antonio, Rodriguez Jimenez, Roberto, Berrocoso, Esther, Leza, Juan Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/209205
Acceso en línea:https://hdl.handle.net/2445/209205
Access Level:acceso abierto
Palabra clave:Prolactina
Psicosi
Cognició
Oxitocina
Diferències entre sexes (Psicologia)
Prolactin
Psychoses
Cognition
Oxytocin
Sex differences (Psychology)
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spelling The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performanceHidalgo Figueroa, MaríaSalazar, AlejandroRomero López-Alberca, CristinaMacDowell, Karina S.García Bueno, BorjaBioque Alcázar, MiquelBernardo Vilamitjana, MercèParellada, MaraGonzález-Pinto, AnaGarcía Portilla, María PazLobo, AntonioRodriguez Jimenez, RobertoBerrocoso, EstherLeza, Juan CarlosProlactinaPsicosiCognicióOxitocinaDiferències entre sexes (Psicologia)ProlactinPsychosesCognitionOxytocinSex differences (Psychology)Background: Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is of interest to identify cognitive and biological markers that will help improve the diagnosis, treatment, and outcome of such events and to define new therapeutic targets. Here we analyzed the plasma oxytocin and prolactin levels during an FEP, assessing their correlation with clinical and cognitive features. Methods: The oxytocin and prolactin in plasma was measured in 120 FEP patients and 106 healthy controls, all of whom were subjected to a clinical and neuropsychological assessment. Most patients were under antipsychotics. Statistical analyses aimed to identify factors associated with the FEP and to search for associations between the variables. This study is preliminary and exploratory because the P-values were not corrected for multiple comparisons. Results: FEP patients had less oxytocin, more prolactin, and a poor premorbid IQ, and they performed worse in sustained attention. Male patients with higher prolactin levels experienced more severe psychotic symptoms and required higher doses of antipsychotics. Low oxytocin was associated with poor sustained attention in women, whereas low oxytocin and high prolactin in men correlated with better performance in sustained attention. Conclusion: Low oxytocin, high prolactin, and poor premorbid IQ and sustained attention are factors associated with an FEP, representing potential therapeutic targets in these patients. These biological factors and cognitive domains might play an important role during a FEP, which could help us to develop new strategies that improve the outcomes of this disorder and that should perhaps be gender specific.Oxford University Press2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/209205Articles publicats en revistes (Empresa)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1093/ijnp/pyac023International Journal of Neuropsychopharmacology, 2022, vol. 25, num.8, p. 666-677https://doi.org/10.1093/ijnp/pyac023cc-by-nc (c) Hidalgo-Figueroa, M. et al., 2022http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2092052026-05-27T06:46:51Z
dc.title.none.fl_str_mv The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
title The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
spellingShingle The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
Hidalgo Figueroa, María
Prolactina
Psicosi
Cognició
Oxitocina
Diferències entre sexes (Psicologia)
Prolactin
Psychoses
Cognition
Oxytocin
Sex differences (Psychology)
title_short The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
title_full The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
title_fullStr The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
title_full_unstemmed The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
title_sort The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
dc.creator.none.fl_str_mv Hidalgo Figueroa, María
Salazar, Alejandro
Romero López-Alberca, Cristina
MacDowell, Karina S.
García Bueno, Borja
Bioque Alcázar, Miquel
Bernardo Vilamitjana, Mercè
Parellada, Mara
González-Pinto, Ana
García Portilla, María Paz
Lobo, Antonio
Rodriguez Jimenez, Roberto
Berrocoso, Esther
Leza, Juan Carlos
author Hidalgo Figueroa, María
author_facet Hidalgo Figueroa, María
Salazar, Alejandro
Romero López-Alberca, Cristina
MacDowell, Karina S.
García Bueno, Borja
Bioque Alcázar, Miquel
Bernardo Vilamitjana, Mercè
Parellada, Mara
González-Pinto, Ana
García Portilla, María Paz
Lobo, Antonio
Rodriguez Jimenez, Roberto
Berrocoso, Esther
Leza, Juan Carlos
author_role author
author2 Salazar, Alejandro
Romero López-Alberca, Cristina
MacDowell, Karina S.
García Bueno, Borja
Bioque Alcázar, Miquel
Bernardo Vilamitjana, Mercè
Parellada, Mara
González-Pinto, Ana
García Portilla, María Paz
Lobo, Antonio
Rodriguez Jimenez, Roberto
Berrocoso, Esther
Leza, Juan Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Prolactina
Psicosi
Cognició
Oxitocina
Diferències entre sexes (Psicologia)
Prolactin
Psychoses
Cognition
Oxytocin
Sex differences (Psychology)
topic Prolactina
Psicosi
Cognició
Oxitocina
Diferències entre sexes (Psicologia)
Prolactin
Psychoses
Cognition
Oxytocin
Sex differences (Psychology)
description Background: Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is of interest to identify cognitive and biological markers that will help improve the diagnosis, treatment, and outcome of such events and to define new therapeutic targets. Here we analyzed the plasma oxytocin and prolactin levels during an FEP, assessing their correlation with clinical and cognitive features. Methods: The oxytocin and prolactin in plasma was measured in 120 FEP patients and 106 healthy controls, all of whom were subjected to a clinical and neuropsychological assessment. Most patients were under antipsychotics. Statistical analyses aimed to identify factors associated with the FEP and to search for associations between the variables. This study is preliminary and exploratory because the P-values were not corrected for multiple comparisons. Results: FEP patients had less oxytocin, more prolactin, and a poor premorbid IQ, and they performed worse in sustained attention. Male patients with higher prolactin levels experienced more severe psychotic symptoms and required higher doses of antipsychotics. Low oxytocin was associated with poor sustained attention in women, whereas low oxytocin and high prolactin in men correlated with better performance in sustained attention. Conclusion: Low oxytocin, high prolactin, and poor premorbid IQ and sustained attention are factors associated with an FEP, representing potential therapeutic targets in these patients. These biological factors and cognitive domains might play an important role during a FEP, which could help us to develop new strategies that improve the outcomes of this disorder and that should perhaps be gender specific.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/209205
url https://hdl.handle.net/2445/209205
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1093/ijnp/pyac023
International Journal of Neuropsychopharmacology, 2022, vol. 25, num.8, p. 666-677
https://doi.org/10.1093/ijnp/pyac023
dc.rights.none.fl_str_mv cc-by-nc (c) Hidalgo-Figueroa, M. et al., 2022
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Hidalgo-Figueroa, M. et al., 2022
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Empresa)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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