Supplementary Materials for Lipid nanoparticles for oligonucleotide delivery into brain border-associated macrophages to silence neuroinflammation-related genes

Supplementary Figure S1. Stability control by 1H-NMR spectroscopy check for covalent stability in the synthetized compound DSPE-PEG-MAN as obtained by click-chemistry mannosylation of the succinimide ligand DSPE-PE-NHS. Supplementary Figure S2A. Catalogue of GapmeR-based lipid nanoparticles (GR@LNPs...

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Detalhes bibliográficos
Autores: Calero, Macarena, Moleiro, Lara H., Sayd, Aline, Dorca, Yeray, Miquel-Rio, Lluís, Paz, Verónica, Robledo-Montaña, Javier, Enciso, Eduardo, Acción, Fernando, Herráez-Aguilar, Diego, Hellweg, Thomas, Sánchez, Luis, Bortolozzi, Analía, Leza, Juan C., García-Bueno, Borja, Monroy, Francisco
Formato: conjunto de datos
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/330045
Acesso em linha:http://hdl.handle.net/10261/330045
Access Level:acceso abierto
Descrição
Resumo:Supplementary Figure S1. Stability control by 1H-NMR spectroscopy check for covalent stability in the synthetized compound DSPE-PEG-MAN as obtained by click-chemistry mannosylation of the succinimide ligand DSPE-PE-NHS. Supplementary Figure S2A. Catalogue of GapmeR-based lipid nanoparticles (GR@LNPs). Type A) Compact GR-DChol archetype; Type B) Stratified core-shell population Supplementary Figure S2B. GR@LNPs’ catalogue (cont.). Type C) Hollow, non-complexed with GapmeR @LNPs Supplementary Figure S3. Ultrastructural analysis of the TEM images in terms of the inhomogenous lamellar structure factor. Supplementary Table T1. Best fit parameters from TEM-ultrastructural analysis performed in terms of the inhomogenous lamellar structure factor.

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