Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients

AIM: To evaluate the effects of surgical weight loss (Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients. METHODS: A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m2 who underwent open...

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Autores: Vargas, Víctor, Allende, Helena, Lecube Torelló, Albert, Salcedo, Maria Teresa, Baena-Fustegueras, Juan A, Fort, José Manuel, Rivero, Joaquín, Ferrer, Roser, Catalán, Roberto, Pardina, Eva, Ramón y Cajal, Santiago, Guardia, Jaime, Peinado-Onsurbe, Julia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/56598
Acceso en línea:https://doi.org/10.4254/wjh.v4.i12.382
http://hdl.handle.net/10459.1/56598
Access Level:acceso abierto
Palabra clave:Non alcoholic fatty liver disease
Bariatric surgery
Obesity
Non alcoholic steatohepatitis
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spelling Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patientsVargas, VíctorAllende, HelenaLecube Torelló, AlbertSalcedo, Maria TeresaBaena-Fustegueras, Juan AFort, José ManuelRivero, JoaquínFerrer, RoserCatalán, RobertoPardina, EvaRamón y Cajal, SantiagoGuardia, JaimePeinado-Onsurbe, JuliaNon alcoholic fatty liver diseaseBariatric surgeryObesityNon alcoholic steatohepatitisAIM: To evaluate the effects of surgical weight loss (Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients. METHODS: A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m2 who underwent open surgical weight loss operations had paired liver biopsies, the first at surgery and the second after 16 ± 3 mo of weight loss. Biopsies were evaluated and compared in a blinded fashion. The presence of metabolic syndrome, anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy. RESULTS: Percentage of excess weight loss was 72.1% ± 6.6%. There was a reduction in prevalence of metabolic syndrome from 57.7% (15 patients) to 7.7% (2 patients) (P < 0.001). Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery. There were improvements in steatosis (P < 0.001), lobular (P < 0.001) and portal (P < 0.05) inflammation and fibrosis (P < 0.001) at the second biopsy. There were 25 (96.1%) patients with non alcoholic steatohepatitis (NASH) in their index biopsy and only four (15.3%) of the repeat biopsies fulfilled the criteria for NASH. The persistence of fibrosis (F > 1) was present in five patients at second biopsy. Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery. CONCLUSION: Restrictive mildly malabsorptive surgery provides significant weight loss, resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients.Baishideng Publishing Group2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.4254/wjh.v4.i12.382http://hdl.handle.net/10459.1/56598reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.4254/wjh.v4.i12.382World Journal of Hepatology, 2012, vol.4, núm. 12, p. 382-388cc-by-nc, (c) Baishideng Publishing Group, 2012info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/3.0/es/oai:repositori.udl.cat:10459.1/565982026-06-24T12:42:17Z
dc.title.none.fl_str_mv Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
title Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
spellingShingle Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
Vargas, Víctor
Non alcoholic fatty liver disease
Bariatric surgery
Obesity
Non alcoholic steatohepatitis
title_short Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
title_full Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
title_fullStr Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
title_full_unstemmed Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
title_sort Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients
dc.creator.none.fl_str_mv Vargas, Víctor
Allende, Helena
Lecube Torelló, Albert
Salcedo, Maria Teresa
Baena-Fustegueras, Juan A
Fort, José Manuel
Rivero, Joaquín
Ferrer, Roser
Catalán, Roberto
Pardina, Eva
Ramón y Cajal, Santiago
Guardia, Jaime
Peinado-Onsurbe, Julia
author Vargas, Víctor
author_facet Vargas, Víctor
Allende, Helena
Lecube Torelló, Albert
Salcedo, Maria Teresa
Baena-Fustegueras, Juan A
Fort, José Manuel
Rivero, Joaquín
Ferrer, Roser
Catalán, Roberto
Pardina, Eva
Ramón y Cajal, Santiago
Guardia, Jaime
Peinado-Onsurbe, Julia
author_role author
author2 Allende, Helena
Lecube Torelló, Albert
Salcedo, Maria Teresa
Baena-Fustegueras, Juan A
Fort, José Manuel
Rivero, Joaquín
Ferrer, Roser
Catalán, Roberto
Pardina, Eva
Ramón y Cajal, Santiago
Guardia, Jaime
Peinado-Onsurbe, Julia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Non alcoholic fatty liver disease
Bariatric surgery
Obesity
Non alcoholic steatohepatitis
topic Non alcoholic fatty liver disease
Bariatric surgery
Obesity
Non alcoholic steatohepatitis
description AIM: To evaluate the effects of surgical weight loss (Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients. METHODS: A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m2 who underwent open surgical weight loss operations had paired liver biopsies, the first at surgery and the second after 16 ± 3 mo of weight loss. Biopsies were evaluated and compared in a blinded fashion. The presence of metabolic syndrome, anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy. RESULTS: Percentage of excess weight loss was 72.1% ± 6.6%. There was a reduction in prevalence of metabolic syndrome from 57.7% (15 patients) to 7.7% (2 patients) (P < 0.001). Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery. There were improvements in steatosis (P < 0.001), lobular (P < 0.001) and portal (P < 0.05) inflammation and fibrosis (P < 0.001) at the second biopsy. There were 25 (96.1%) patients with non alcoholic steatohepatitis (NASH) in their index biopsy and only four (15.3%) of the repeat biopsies fulfilled the criteria for NASH. The persistence of fibrosis (F > 1) was present in five patients at second biopsy. Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery. CONCLUSION: Restrictive mildly malabsorptive surgery provides significant weight loss, resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.4254/wjh.v4.i12.382
http://hdl.handle.net/10459.1/56598
url https://doi.org/10.4254/wjh.v4.i12.382
http://hdl.handle.net/10459.1/56598
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.4254/wjh.v4.i12.382
World Journal of Hepatology, 2012, vol.4, núm. 12, p. 382-388
dc.rights.none.fl_str_mv cc-by-nc, (c) Baishideng Publishing Group, 2012
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/3.0/es/
rights_invalid_str_mv cc-by-nc, (c) Baishideng Publishing Group, 2012
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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