Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)

Cuadrado Corrales, María Natividad; López De Andrés, Ana Isabel; Hernández-Barrera, Valentín; Carabantes Alarcón, David; Zamorano León, José Javier; Omaña Palanco, Ricardo; Del Barrio, José L.; Miguel Díez, Javier De; Jiménez García, Rodrigo; Montoya Miñano, Juan José

Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)

Epidermolysis bullosa (EB) comprises a group of rare skin diseases. We assessed diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), costs, and in-hospital mortality (IHM) associated with EB. (2) Methods: A retrospective, population-based observational study was performed usi...

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Autores:	Cuadrado Corrales, María Natividad, López De Andrés, Ana Isabel, Hernández-Barrera, Valentín, Carabantes Alarcón, David, Zamorano León, José Javier, Omaña Palanco, Ricardo, Del Barrio, José L., Miguel Díez, Javier De, Jiménez García, Rodrigo, Montoya Miñano, Juan José
Formato:	artículo
Fecha de publicación:	2023
País:	España
Recursos:	Universidad Complutense de Madrid (UCM)
Repositorio:	Docta Complutense
Idioma:	inglés
OAI Identifier:	oai:docta.ucm.es:20.500.14352/99644
Acesso em linha:	https://hdl.handle.net/20.500.14352/99644
Access Level:	acceso abierto
Palavra-chave:	61 Epidermolysis bullosa Comorbidity In-hospital mortality Length of hospital Stay cost of illness Ciencias Biomédicas 32 Ciencias Médicas

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spelling	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)Cuadrado Corrales, María NatividadLópez De Andrés, Ana IsabelHernández-Barrera, ValentínCarabantes Alarcón, DavidZamorano León, José JavierOmaña Palanco, RicardoDel Barrio, José L.Miguel Díez, Javier DeJiménez García, RodrigoMontoya Miñano, Juan José61Epidermolysis bullosaComorbidityIn-hospital mortalityLength of hospitalStay cost of illnessCiencias Biomédicas32 Ciencias MédicasEpidermolysis bullosa (EB) comprises a group of rare skin diseases. We assessed diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), costs, and in-hospital mortality (IHM) associated with EB. (2) Methods: A retrospective, population-based observational study was performed using the Spanish National Hospital Discharge Database. Hospitalized patients with EB in Spain were identified for the period 2016 to 2021. (3) Results: A total of 677 hospitalizations were identified among 342 patients with a diagnosis of EB. Fifty percent of patients had at least one readmission during the 6-year follow-up. Notably, rehospitalizations were more common among patients aged 2-17 years. The most prevalent comorbidity was digestive disorders, which were associated with the frequency of esophageal dilatation procedures and percutaneous endoscopic gastrostomy. The longest LOHS was recorded for the 0- to 1-year age group. IHM increased with age, and the difference was statistically significant. The prevalence of malignant neoplasm was 36.88%, with cutaneous squamous cell carcinoma being the most frequent. The overall cost per hospitalized patient was estimated to be EUR 10,895.22 (SD EUR 13,394.81), with significant variations between age groups. (4) Conclusions: Readmissions are very frequent among people with EB. We observed a higher LOHS in the 0- to 1-year age group, while the highest rates of IHM were observed in patients older than 50 years. There was a substantial prevalence of comorbidities, namely, digestive disorders, infectious diseases, and especially cancer.MDPIMDPIUniversidad Complutense de Madrid20232023-10-0120232023-10-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/99644reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/996442026-06-02T12:44:21Z
dc.title.none.fl_str_mv	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)
title	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)
spellingShingle	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021) Cuadrado Corrales, María Natividad 61 Epidermolysis bullosa Comorbidity In-hospital mortality Length of hospital Stay cost of illness Ciencias Biomédicas 32 Ciencias Médicas
title_short	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)
title_full	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)
title_fullStr	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)
title_full_unstemmed	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)
title_sort	Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)
dc.creator.none.fl_str_mv	Cuadrado Corrales, María Natividad López De Andrés, Ana Isabel Hernández-Barrera, Valentín Carabantes Alarcón, David Zamorano León, José Javier Omaña Palanco, Ricardo Del Barrio, José L. Miguel Díez, Javier De Jiménez García, Rodrigo Montoya Miñano, Juan José
author	Cuadrado Corrales, María Natividad
author_facet	Cuadrado Corrales, María Natividad López De Andrés, Ana Isabel Hernández-Barrera, Valentín Carabantes Alarcón, David Zamorano León, José Javier Omaña Palanco, Ricardo Del Barrio, José L. Miguel Díez, Javier De Jiménez García, Rodrigo Montoya Miñano, Juan José
author_role	author
author2	López De Andrés, Ana Isabel Hernández-Barrera, Valentín Carabantes Alarcón, David Zamorano León, José Javier Omaña Palanco, Ricardo Del Barrio, José L. Miguel Díez, Javier De Jiménez García, Rodrigo Montoya Miñano, Juan José
author2_role	author author author author author author author author author
dc.contributor.none.fl_str_mv	MDPI Universidad Complutense de Madrid
dc.subject.none.fl_str_mv	61 Epidermolysis bullosa Comorbidity In-hospital mortality Length of hospital Stay cost of illness Ciencias Biomédicas 32 Ciencias Médicas
topic	61 Epidermolysis bullosa Comorbidity In-hospital mortality Length of hospital Stay cost of illness Ciencias Biomédicas 32 Ciencias Médicas
description	Epidermolysis bullosa (EB) comprises a group of rare skin diseases. We assessed diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), costs, and in-hospital mortality (IHM) associated with EB. (2) Methods: A retrospective, population-based observational study was performed using the Spanish National Hospital Discharge Database. Hospitalized patients with EB in Spain were identified for the period 2016 to 2021. (3) Results: A total of 677 hospitalizations were identified among 342 patients with a diagnosis of EB. Fifty percent of patients had at least one readmission during the 6-year follow-up. Notably, rehospitalizations were more common among patients aged 2-17 years. The most prevalent comorbidity was digestive disorders, which were associated with the frequency of esophageal dilatation procedures and percutaneous endoscopic gastrostomy. The longest LOHS was recorded for the 0- to 1-year age group. IHM increased with age, and the difference was statistically significant. The prevalence of malignant neoplasm was 36.88%, with cutaneous squamous cell carcinoma being the most frequent. The overall cost per hospitalized patient was estimated to be EUR 10,895.22 (SD EUR 13,394.81), with significant variations between age groups. (4) Conclusions: Readmissions are very frequent among people with EB. We observed a higher LOHS in the 0- to 1-year age group, while the highest rates of IHM were observed in patients older than 50 years. There was a substantial prevalence of comorbidities, namely, digestive disorders, infectious diseases, and especially cancer.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023-10-01 2023 2023-10-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.14352/99644
url	https://hdl.handle.net/20.500.14352/99644
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM)
instname_str	Universidad Complutense de Madrid (UCM)
reponame_str	Docta Complutense
collection	Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Clinical Characteristics and Outcomes of Patients Hospitalized with Epidermolysis Bullosa: A Retrospective Population-Based Observational Study in Spain (2016-2021)

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