Molecular and Cellular Mechanisms of Synaptopathies

Synapses, contact points between neurons, are essential elements supporting the ability of neurons to communicate and to transmit relevant information to each other. They play an integral role in brain development and wiring neurons into neural circuits, for example, those related to our behavior. T...

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Autores: Ardiles, Álvaro O., Grabrucker, Andreas M., Gómez Scholl, Francisco Manuel, Rudenko, Gabby, Borsello, Tiziana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/161759
Acceso en línea:https://hdl.handle.net/11441/161759
https://doi.org/10.1155/2017/2643943
Access Level:acceso abierto
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spelling Molecular and Cellular Mechanisms of SynaptopathiesArdiles, Álvaro O.Grabrucker, Andreas M.Gómez Scholl, Francisco ManuelRudenko, GabbyBorsello, TizianaSynapses, contact points between neurons, are essential elements supporting the ability of neurons to communicate and to transmit relevant information to each other. They play an integral role in brain development and wiring neurons into neural circuits, for example, those related to our behavior. Therefore, alterations affecting the integrity and/or functionality of synapses can lead to synaptic pathologies or synaptopathies. For instance, many neurological disorders including Alzheimer’s disease, Down syndrome, epilepsy, and Parkinson’s disease and neurodevelopmental disorders such as autism spectrum disorders, intellectual disability, and fragile X syndrome have consistently been reported to exhibit abnormalities in synaptic composition, morphology, and function. This special issue discusses various aspects of the molecular interactions that underlie synaptic protein networks and the complex signaling pathways that are activated by them, knowledge that is crucial to understand the cellular and molecular mechanisms involved in different synaptopathies. Synapses comprise a presynaptic compartment, consisting of the axon terminal and their protein machinery implicated in the release of neurotransmitters. Upon exocytosis of presynaptic vesicles, neurotransmitters spill out into the extracellular space called the “synaptic cleft” and diffuse to reach a postsynaptic compartment, composed of the protein machinery that receives and transduces the neurotransmitter-induced signals [1]. Most synaptopathies directly or indirectly affect the molecular repertoire of synaptic proteins.Wiley Open AccessFisiología Médica y BiofísicaNIMH NIH HHS2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11441/161759https://doi.org/10.1155/2017/2643943reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésNeural Plasticity, 2017, 2643943.R01 MH077303https://onlinelibrary.wiley.com/doi/10.1155/2017/2643943info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1617592026-06-17T12:51:07Z
dc.title.none.fl_str_mv Molecular and Cellular Mechanisms of Synaptopathies
title Molecular and Cellular Mechanisms of Synaptopathies
spellingShingle Molecular and Cellular Mechanisms of Synaptopathies
Ardiles, Álvaro O.
title_short Molecular and Cellular Mechanisms of Synaptopathies
title_full Molecular and Cellular Mechanisms of Synaptopathies
title_fullStr Molecular and Cellular Mechanisms of Synaptopathies
title_full_unstemmed Molecular and Cellular Mechanisms of Synaptopathies
title_sort Molecular and Cellular Mechanisms of Synaptopathies
dc.creator.none.fl_str_mv Ardiles, Álvaro O.
Grabrucker, Andreas M.
Gómez Scholl, Francisco Manuel
Rudenko, Gabby
Borsello, Tiziana
author Ardiles, Álvaro O.
author_facet Ardiles, Álvaro O.
Grabrucker, Andreas M.
Gómez Scholl, Francisco Manuel
Rudenko, Gabby
Borsello, Tiziana
author_role author
author2 Grabrucker, Andreas M.
Gómez Scholl, Francisco Manuel
Rudenko, Gabby
Borsello, Tiziana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
NIMH NIH HHS
description Synapses, contact points between neurons, are essential elements supporting the ability of neurons to communicate and to transmit relevant information to each other. They play an integral role in brain development and wiring neurons into neural circuits, for example, those related to our behavior. Therefore, alterations affecting the integrity and/or functionality of synapses can lead to synaptic pathologies or synaptopathies. For instance, many neurological disorders including Alzheimer’s disease, Down syndrome, epilepsy, and Parkinson’s disease and neurodevelopmental disorders such as autism spectrum disorders, intellectual disability, and fragile X syndrome have consistently been reported to exhibit abnormalities in synaptic composition, morphology, and function. This special issue discusses various aspects of the molecular interactions that underlie synaptic protein networks and the complex signaling pathways that are activated by them, knowledge that is crucial to understand the cellular and molecular mechanisms involved in different synaptopathies. Synapses comprise a presynaptic compartment, consisting of the axon terminal and their protein machinery implicated in the release of neurotransmitters. Upon exocytosis of presynaptic vesicles, neurotransmitters spill out into the extracellular space called the “synaptic cleft” and diffuse to reach a postsynaptic compartment, composed of the protein machinery that receives and transduces the neurotransmitter-induced signals [1]. Most synaptopathies directly or indirectly affect the molecular repertoire of synaptic proteins.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/161759
https://doi.org/10.1155/2017/2643943
url https://hdl.handle.net/11441/161759
https://doi.org/10.1155/2017/2643943
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neural Plasticity, 2017, 2643943.
R01 MH077303
https://onlinelibrary.wiley.com/doi/10.1155/2017/2643943
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley Open Access
publisher.none.fl_str_mv Wiley Open Access
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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