Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy

Simple Summary Chemotoxicity, unplanned hospitalizations (Uhs) and early death (ED) are common among older patients with cancer who receive chemotherapy. Our objective was to determine factors predicting these complications. A predictive score for these three complications based on geriatric, tumor...

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Autores: Feliu, Jaime, Espinosa, Enrique, Basterretxea, Laura, Paredero Pérez, Irene, Llabrés, Elisenda, Jiménez Munárriz, Beatriz, Antonio, Maite, Losada, Beatriz, Pinto, Alvaro, Custodio, Ana Belén, Muñoz, María del Mar, Gómez-mediavilla, Jenifer, Torregrosa Carné, Maria Dolors, Soler, Gema, Cruz, Patricia, Higuera, Oliver, Molina Garrido, María José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183397
Acceso en línea:https://hdl.handle.net/2445/183397
Access Level:acceso abierto
Palabra clave:Càncer colorectal
Quimioteràpia del càncer
Colorectal cancer
Cancer chemotherapy
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spelling Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with ChemotherapyFeliu, JaimeEspinosa, EnriqueBasterretxea, LauraParedero Pérez, IreneLlabrés, ElisendaJiménez Munárriz, BeatrizAntonio, MaiteLosada, BeatrizPinto, AlvaroCustodio, Ana BelénMuñoz, María del MarGómez-mediavilla, JeniferTorregrosa Carné, Maria DolorsSoler, GemaCruz, PatriciaHiguera, OliverMolina Garrido, María JoséCàncer colorectalQuimioteràpia del càncerColorectal cancerCancer chemotherapySimple Summary Chemotoxicity, unplanned hospitalizations (Uhs) and early death (ED) are common among older patients with cancer who receive chemotherapy. Our objective was to determine factors predicting these complications. A predictive score for these three complications based on geriatric, tumor and laboratory variables was developed in a series of 215 older patients with colorectal carcinoma receiving chemotherapy. The use of this score may reliably identify patients at risk to have excessive toxicity with chemotherapy, UH or ED, thus helping to plan treatment, implement adaptive measures, and intensify follow-up. Purpose: To identify risk factors for toxicity, unplanned hospitalization (UH) and early death (ED) in older patients with colorectal carcinoma (CRC) initiating chemotherapy. Methods: 215 patients over 70 years were prospectively included. Geriatric assessment was performed before treatment, and tumor and treatment variables were collected. The association between these factors and grade 3-5 toxicity, UH and ED (<6 months) was examined by using multivariable logistic regression. Score points were assigned to each risk factor. Results: During the first 6 months of treatment, 33% of patients developed grade 3-5 toxicity, 31% had UH and 23% died. Risk factors were, for toxicity, instrumental activities of daily living, creatinine clearance, weight loss and MAX2 index; for UH, Charlson Comorbidity Score, creatinine clearance, weight loss, serum albumin, and metastatic disease; and for ED, basic activities in daily living, weight loss, metastatic disease, and hemoglobin levels. Predictive scores were built with these variables. The areas under receiver operation characteristic (ROC) curves for toxicity, UH and ED were 0.70 (95% CI: 0.64-0.766), 0.726 (95% IC: 0.661-0.799) and 0.74 (95% IC: 0.678-0.809), respectively. Conclusion: Simple scores based on geriatric, tumor and laboratory characteristics predict severe toxicity, UH and ED, and may help in treatment planning.MDPI AG2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183397Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cancers14010127Cancers, 2021, vol 14, num 1https://doi.org/10.3390/cancers14010127cc by (c) Feliu, Jaime et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1833972026-05-27T06:46:51Z
dc.title.none.fl_str_mv Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
title Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
spellingShingle Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
Feliu, Jaime
Càncer colorectal
Quimioteràpia del càncer
Colorectal cancer
Cancer chemotherapy
title_short Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
title_full Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
title_fullStr Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
title_full_unstemmed Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
title_sort Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
dc.creator.none.fl_str_mv Feliu, Jaime
Espinosa, Enrique
Basterretxea, Laura
Paredero Pérez, Irene
Llabrés, Elisenda
Jiménez Munárriz, Beatriz
Antonio, Maite
Losada, Beatriz
Pinto, Alvaro
Custodio, Ana Belén
Muñoz, María del Mar
Gómez-mediavilla, Jenifer
Torregrosa Carné, Maria Dolors
Soler, Gema
Cruz, Patricia
Higuera, Oliver
Molina Garrido, María José
author Feliu, Jaime
author_facet Feliu, Jaime
Espinosa, Enrique
Basterretxea, Laura
Paredero Pérez, Irene
Llabrés, Elisenda
Jiménez Munárriz, Beatriz
Antonio, Maite
Losada, Beatriz
Pinto, Alvaro
Custodio, Ana Belén
Muñoz, María del Mar
Gómez-mediavilla, Jenifer
Torregrosa Carné, Maria Dolors
Soler, Gema
Cruz, Patricia
Higuera, Oliver
Molina Garrido, María José
author_role author
author2 Espinosa, Enrique
Basterretxea, Laura
Paredero Pérez, Irene
Llabrés, Elisenda
Jiménez Munárriz, Beatriz
Antonio, Maite
Losada, Beatriz
Pinto, Alvaro
Custodio, Ana Belén
Muñoz, María del Mar
Gómez-mediavilla, Jenifer
Torregrosa Carné, Maria Dolors
Soler, Gema
Cruz, Patricia
Higuera, Oliver
Molina Garrido, María José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer colorectal
Quimioteràpia del càncer
Colorectal cancer
Cancer chemotherapy
topic Càncer colorectal
Quimioteràpia del càncer
Colorectal cancer
Cancer chemotherapy
description Simple Summary Chemotoxicity, unplanned hospitalizations (Uhs) and early death (ED) are common among older patients with cancer who receive chemotherapy. Our objective was to determine factors predicting these complications. A predictive score for these three complications based on geriatric, tumor and laboratory variables was developed in a series of 215 older patients with colorectal carcinoma receiving chemotherapy. The use of this score may reliably identify patients at risk to have excessive toxicity with chemotherapy, UH or ED, thus helping to plan treatment, implement adaptive measures, and intensify follow-up. Purpose: To identify risk factors for toxicity, unplanned hospitalization (UH) and early death (ED) in older patients with colorectal carcinoma (CRC) initiating chemotherapy. Methods: 215 patients over 70 years were prospectively included. Geriatric assessment was performed before treatment, and tumor and treatment variables were collected. The association between these factors and grade 3-5 toxicity, UH and ED (<6 months) was examined by using multivariable logistic regression. Score points were assigned to each risk factor. Results: During the first 6 months of treatment, 33% of patients developed grade 3-5 toxicity, 31% had UH and 23% died. Risk factors were, for toxicity, instrumental activities of daily living, creatinine clearance, weight loss and MAX2 index; for UH, Charlson Comorbidity Score, creatinine clearance, weight loss, serum albumin, and metastatic disease; and for ED, basic activities in daily living, weight loss, metastatic disease, and hemoglobin levels. Predictive scores were built with these variables. The areas under receiver operation characteristic (ROC) curves for toxicity, UH and ED were 0.70 (95% CI: 0.64-0.766), 0.726 (95% IC: 0.661-0.799) and 0.74 (95% IC: 0.678-0.809), respectively. Conclusion: Simple scores based on geriatric, tumor and laboratory characteristics predict severe toxicity, UH and ED, and may help in treatment planning.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183397
url https://hdl.handle.net/2445/183397
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers14010127
Cancers, 2021, vol 14, num 1
https://doi.org/10.3390/cancers14010127
dc.rights.none.fl_str_mv cc by (c) Feliu, Jaime et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Feliu, Jaime et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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